Circulation
Articles in this Issue
Abstract 4343741: Massive Aortic Root Thrombus and Coronary Embolization in a Heart Transplant Recipient on Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO) for Graft Dysfunction: An Imaging Case Report
A 44-year-old recent heart transplant recipient supported by VA-ECMO presented to the operating room (OR) for left ventricular (LV) vent removal. She had a history of double-inlet LV with right atriov...
Abstract 4366766: Computational Analysis of Right Ventricular Motion to Optimize Energy Harvesting in Leadless Pacemaker Design
Introduction: Leadless pacemakers (LP) have addressed many complications of traditional lead-based transvenous designs. However, their reliance on internal batteries remains a limi...
Abstract 4372104: Prostate Cancer Imposes Significant Risk for Cardiovascular Events: Insights from the CLARIFY Registry
Background: Prostate cancer tends to be a slow-growing malignancy, and oftentimes patient mortality is the result of non-cancerous disease processes. Recent studies have identified...
Abstract 4361389: Long-Term Outcomes in Patients with Lone Elevated Coronary Artery Calcium and No Traditional Risk Factors: A 5- and 10-Year Propensity-Matched Analysis
Introduction: Coronary artery calcium (CAC) scoring improves cardiovascular risk prediction, especially in patients with intermediate risk. However, the long-term implications of e...
Abstract 4362795: Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B
Background: Decline in renal function is common in patients (pts) with transthyretin amyloidosis (ATTR) and is a marker of disease progression associated with mortality in ATTR wit...
Abstract 4366392: Comparable Improvement of a Sensor-Controlled Digital Game Intervention and a Sensor-Based Control on Self-Care and Outcomes in Older Adults with Heart Failure: A Randomized Controlled Trial
Introduction: Older adults with heart failure (HF) have well-established barriers to consistent engagement in effective self-care behaviors. Inadequate self-care leads to declines...
Abstract 4347644: Colchicine and Cardiovascular Outcomes in Patients With Coronary Artery Disease and Elevated C Reactive Protein
Background: Colchicine, an anti-inflammatory agent, has been investigated for reducing cardiovascular risk in patients with atherosclerotic coronary artery disease (CAD). This stud...
Abstract 4371503: Virtual Surgical Planning for Thoracic Access Port Placement in Patients with Congenital Heart Disease: A Pre-Surgical Study in Pediatric and Adult Cases
Background: Epicardial pacemaker lead placement is often required in patients with congenital heart disease (CHD) who are not candidates for transvenous systems. However, tradition...
Abstract 4369919: Association Between Antihypertensive Polypharmacy and Midlife Cognitive Function: Insights from the Bogalusa Heart Study
Introduction: While hypertension is a well-established risk factor for cognitive decline, the relationship between the number of antihypertensive medications (AHMs) used and cognit...
Abstract 4372327: Preoperative Intra-Aortic Balloon Pump Use and Surgical Outcomes in Acute Mitral Regurgitation
Background: Acute mitral regurgitation (MR) is a critical condition that often necessitates urgent surgical intervention. While intra-aortic balloon pump (IABP) therapy is recommen...
Abstract 4365849: Selective Degradation of Excess Free Cholesterol in the Liver by REP-0003 Regresses Atherosclerotic Plaque in <i> Ldlr <sup>-/-</sup> </i> Mice: A Novel Approach for HoFH
Introduction: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder caused by loss-of-function mutations in the low-density lipoprotein receptor...
Abstract 4362480: East Asian-specific genome-wide association study and multi-ancestry meta-analysis reveal the genetic foundations for valvular heart disease and its subtypes
Background: The genetic architectures of valvular heart disease (VHD) and its subtypes have yet to be fully elucidated. Ai...
Abstract 4361478: Turning the Corner: The Life Saving Potential of Timely CABG Intervention in Elderly Ventilated Patients: A Case Series
Introduction: As the global elderly population grows, so does the incidence of acute coronary syndrome (ACS) requiring urgent intervention. Emergency coronary artery bypass graftin...
Abstract Sat906: Using Natural Language Processing to Distinguish Recalled Experiences of Death from Drug-Induced Hallucinations and Dreams in Cardiac Arrest and Critical Ill Survivors
Background: Around, 10% of cardiac arrest survivors report vivid Recalled Experiences of Death (RED)— heightened lucidity, visual and auditory awareness, and a perception of a purp...
Abstract 4357470: A Randomized Comparison of Online Motivational Themes in Cardiovascular Clinical Trial Recruitment
Background: Despite bearing a disproportionately high burden of cardiovascular disease, Black adults remain grossly underrepresented in clinical trials. Culturally tailored, digita...
Abstract 4361217: The Impact of Donor-Recipient Race Matching on Development of De Novo Donor-Specific Antibodies After Heart Transplantation
Background: Heart transplantation remains the definitive treatment for end-stage heart failure, but outcomes vary by race. Black patients demonstrate worse survival and race matchi...
Abstract 4364429: Decoding fibromyocytes' contributions to atherosclerosis: from senescence induction to promoting formation of the necrotic core
Background: Smooth muscle cells (SMC), an important cellular component of atherosclerosis, exhibit variant phenotypes after transdifferentiation. Their differentiation into fibromy...
Abstract Sun508: Chest Compression Quality Phenotypes and ROSC in Out-of-Hospital Cardiac Arrest
Background: High-quality chest compressions are associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). However, minute-to-minute chest compression patterns m...
Abstract 4363702: A multi-ethnic foundation model-based artificial intelligence electrocardiogram for detection and prognostication of elevated left ventricular filling pressure
Background: Left ventricular filling pressure (LVFP) is associated with symptoms and signs of heart failure, can guide therapeutic decision-making, and provides prognostic insights...
Abstract 4368831: Right Axillary Thoracotomy for Repair of a Complex Coronary Triad in the Youngest Known Infant: Right Coronary and Sinus Node Artery Aneurysms With Dual Fistulas to the Right Atrium
Case: A 4-month-old female infant presented with cough and fever. A cardiac murmur was noted at the pulmonary valve area. Lab tests revealed mildly elevated WBC and CRP. CXR was un...
Abstract 4367908: Decoding the Regulatory Landscape of KMT2D in Heart Development
Background: Hypoplastic Left Heart Syndrome (HLHS) remains the most lethal form of congenital heart disease (CHD). The next generation of therapies are predicated on understanding...
Abstract 4365052: Bedtime Versus Morning Dosing of Antihypertensives: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: The timing of antihypertensive medication may influence cardiovascular outcomes and blood pressure control, yet the evidence remains inconclusive. Hence, we conducted a...
Abstract 4369009: Near-Maximal Movement Captured by Accelerometry Offers Superior Mortality Risk Prediction Than Aggregate Movement in Heart Failure
Background: There is a growing interest in understanding the impact of tested therapies on real-world functional outcomes as measured by wearable accelerometers (ACC) in heart fail...
Abstract 4368725: Association Between Novel Arterial Wall Atherogenesis Markers With Incident Myocardial Infarction: Observations From The Dallas Heart Study
Background: Although traditional risk factors and chronic inflammation are drivers of coronary artery disease (CAD), risk factors and circulating inflammation markers do not fully...
Abstract 4357973: Sustained Ventricular Tachycardia secondary to Metastatic Sarcoma complicated by Propranolol-Induced Right Ventricular Heart Failure
Description of Case: 63-year-old female with a past medical history of stage II vaginal squamous cell carcinoma in remission, complicated by radiation-induced sarcoma, presented to...