Circulation
Articles in this Issue
Abstract 4364348: Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression
Background: IGF-1 is a major growth factor, which promotes cell proliferation, and survival. IGF-1 reduced atherosclerosis in aortas in Apoe-/- mice and in coronaries in hyperchole...
Abstract 4363421: Comparative Outcomes of Stereotactic Body Radiotherapy for Ventricular Tachycardia in Ischemic vs. Non-Ischemic Cardiomyopathy
Background: Ventricular tachycardia (VT) associated with ischemic (ICM) and non-ischemic cardiomyopathy (NICM) presents distinct substrate patterns, influencing mapping and ablatio...
Abstract 4369810: Pilot randomized controlled trial of a patient-centered mHealth intervention to improve self-care adherence in patients with heart failure
Backround: Self-care is essential for managing heart failure (HF), yet many patients struggle with adherence to prescribed medications, low sodium diet, and daily self-monitoring o...
Abstract 4373105: Prognostic Value of Stress Myocardial Perfusion Imaging in Predicting Major Adverse Cardiovascular Events (MACE): A Systematic Review and Meta-Analysis of 42,000 Patients
Background: Stress myocardial perfusion imaging (MPI), which includes single-photon emission computed tomography (SPECT) and positron emission tomography (PET), is often used to id...
Abstract 4370713: MicroRNA Biomarkers of Cardiac Allograft Vasculopathy after Heart Transplantation
Introduction: Cardiac allograft vasculopathy (CAV), a form of immunologically-mediated coronary disease, is a leading cause of long-term graft failure after heart transplantation (...
Abstract Sun1001: Nampt Is a Critical Regulator of Cardiac Arrest Survival
Introduction: Nicotinamide phosphoribosyltransferase (Nampt) is a rate limiting enzyme that converts nicotinamide (NAM) to nicotinamide mononucleotide (NMN), which is then converte...
Abstract 4342748: A Health Coach-Based Multi-Level Personalized Strategy Lowers LDL-Cholesterol and Enhances Lipid Control in Veterans with Atherosclerotic Cardiovascular Disease – The VA Lipid Optimization Reimagined Quality Improvement Project at VA New York Harbor Healthcare System
Introduction: The VA New York Harbor Healthcare System (NYHHS) is one of 50 VA sites participating in a national quality improvement initiative called the VA Lipid Optimization Rei...
Abstract 4364866: Incidental Peripheral Calcifications on Computed Tomography in Patients Post-PCI Predict Poor Long-Term Outcomes
Introduction: Peripheral artery disease (PAD) is an underrecognized and undertreated condition associated with significant cardiovascular morbidity and mortality. Peripheral calcif...
Abstract 4368200: Comparative Associations of Estrone, Estrone Sulfate, and Estradiol With Cardiovascular Events: Evidence From NHANES 2017–2023
Background: Emerging research underscores the importance of endogenous estrogens in cardiovascular health across sexes. Estrone sulfate, a stable circulating estrogen reservoir, ha...
Abstract 4367097: Oral Anticoagulant Monotherapy vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Stable Coronary Artery Disease Following Percutaneous Coronary Intervention: Insights from a Real-World TriNetX Cohort Study
Background: The optimal long-term antithrombotic strategy in patients with atrial fibrillation (AF) and stable coronary artery disease (CAD) post-percutaneous coronary intervention...
Abstract 4362425: Spatial Organizations of Heterochromatin Underlie Cardiomyocyte Nuclear Structural Integrity Against Mechanical Stress
Introduction: Cardiomyocyte (CM) nuclei endure relentless contraction cycles while preserving nuclear architecture and transcriptional fidelity. In mice engineered for ErbB4-driven...
Abstract 4370659: An Unusual but Clinically Significant Mechanism of Cerebral Fat Embolism Syndrome in Sickle Cell Disease Patient via Patent Foramen Ovale
Introduction: Fat Embolism Syndrome (FES) is a rare but potentially life threatening complication of sickle Cell Disease (SCD). While pulmonary involvement is typical, paradoxical...
Abstract 4364315: Clinical Outcomes of Transcatheter Aortic Valve Replacement in Adults with Congenital Heart Disease: A Nationwide Analysis
Background: As more patients with congenital heart disease (CHD) survive into adulthood, transcatheter aortic valve replacement (TAVR) is increasingly utilized in this complex popu...
Abstract 4370773: Predictors of Left Ventricular Function Recovery After Premature Ventricular Complex Ablation: A Retrospective Study
Background: Catheter ablation of frequent premature ventricular complexes (PVCs) has been demonstrated to improve left ventricular ejection fraction (LVEF) in patients with PVC-ind...
Abstract 4369686: Evaluating Lipid-Lowering Efficacy Of Obicetrapib: An Updated Meta-Analysis of Clinical Trials
Introduction: Obicetrapib, a selective cholesteryl ester transfer protein (CETP) inhibitor, has demonstrated a reduction in low-density lipoprotein cholesterol (LDL-C) and apolipop...
Abstract 4362170: Artificial Intelligence-Enabled Electrocardiogram for Detecting Systolic Dysfunction in Left Bundle Branch Block: Impact of Training Strategies and Transfer Learning
Background: Left bundle branch block (LBBB) is a common ECG abnormality linked to left ventricular systolic dysfunction (LVSD), yet its altered conduction pattern complicates ECG-b...
Abstract 4365658: Pulmonary Hypertension Due to Fibrous Mediastinitis Treated Successfully with Stenting of Pulmonary Artery Stenoses
Introduction: Fibrosing mediastinitis is a rare condition characterized by excessive fibrous tissue proliferation in the mediastinum, leading to compression of vital structures. We...
Abstract 4359337: Galectin-3 and sST2 for Early Risk Prediction in Pediatric Cardiac Failure Requiring Venoarterial Extracorporeal Membrane Oxygenation
Background: Galectin-3 and soluble suppression of tumorigenicity-2 (sST2) are biomarkers of fibrosis and inflammation, with prognostic value in adult cardiac failure both with and...
Abstract 4368498: Artificial Intelligence-enhanced Electrocardiography Sex-Discordance is Associated with Cardiovascular Events and Risk Factors in Women: from the ELSA-Brasil study
Introduction: Using sex as a binary variable may oversimplify the spectrum of inter-individual variability in sex-related cardiovascular (CV) risk. Artificial intelligence–enhanced...
Abstract 4366818: Uncovering the Hidden Link: Vitamin B12 Deficiency as a Predictor of Poor Outcomes in NSTEMI Hospitalizations
Introduction: Vitamin B12 deficiency has been linked to cardiovascular risks, yet its impact on outcomes in patients with acute coronary syndromes, particularly Non-ST Elevation My...
Abstract 4370729: Outcomes of Minimally Invasive Versus Conventional Surgery in Mitral Valve Endocarditis: A Systematic Review and Meta-Analysis.
Introduction: Surgical intervention is crucial in managing infective endocarditis (IE) of the mitral valve. Conventional sternotomy is the standard approach, but minimally invasive...
Abstract 4362484: Nonlinear Association Between Post-Cardiac Arrest Mean Arterial Pressure and Outcome Suggests 85–100 mmHg as the Optimal Range
Introduction: Post-cardiac arrest care seeks to optimize cerebral perfusion for neurological recovery. Mean arterial pressure (MAP) is a key target in hemodynamic management, but g...
Abstract 4342735: Trends in Chronic Kidney Disease Related Mortality Among Heart Failure Patients (1999–2023) in the United States
INTRODUCTION: Heart failure (HF) contributes to the progression and worsening of chronic kidney disease (CKD) by mechanisms like reduced renal perfusion and neurohormonal activatio...
Abstract 4369433: Association Between Cardiovascular-Kidney-Metabolic Syndrome Stages and Cardiovascular Mortality Among Postmenopausal Women: Results from National Health and Nutrition Examination Survey
Background: Cardiovascular disease (CVD) remains the leading cause of death in the U.S., with postmenopausal women aged 55 and older facing heightened risk. To enhance risk stratif...
Abstract 4370557: Cardiovascular Benefits of GLP-1 Receptor Agonists in Non-Obese Patients with Heart-Failure: A Real-World TriNetX Analysis
Background: GLP-1 receptor agonists (GLP-1 RAs), originally approved for glycemic control and weight loss in type 2 diabetes, have demonstrated cardiovascular (CV) benefit in obese...