Circulation
Articles in this Issue
Abstract 4366561: Sex and Race Differences in Social Support and Health-Related Quality of Life in Cardiac Intensive Care Unit Survivors
Introduction: Social support is known to influence health-related quality of life and is associated with health outcomes, such as self-care, hospitalization rate, mortality. Sex an...
Abstract 4371046: Closing or Widening the Gap? Racial, Demographic and Geographic Mortality Disparities in Heart Diseases and Cerebrovascular Diseases Across Two Decades in the U.S. (1999–2020)
Objective: This study aimed to analyze patterns in mortality related to heart and cerebrovascular diseases across different demographic groups and geographic regions in the adult p...
Abstract 4341629: Excess Cardiovascular Events and Healthcare Resource Utilization with Lack of Lipid Lowering Therapy in US Adults with or at Risk of ASCVD
Background: Despite the effectiveness of lipid lowering therapy (LLT), many adults with or at risk of ASCVD are not being treated....
Abstract 4371085: Seasonal Patterns and Geographic Disparities in United States Cardiovascular Mortality between 1999-2020
Introduction: Seasonal, geographic, and socioeconomic factors all influence cardiovascular (CV) mortality. Long-term seasonal trends across United States regions remain insufficien...
Abstract 4373261: India as the Epicenter of Global Rheumatic Heart Disease: A Subnational and Temporal Analysis from 1990 to 2021
Background: Rheumatic heart disease (RHD) continues to impose a significant public health burden globally,primarily as a sequela of untreated or recurrent streptococcal infections....
Abstract 4369885: Low rates of cardiotoxicity during HER2-directed antibody therapy for breast cancer across a large, Western US hospital system
Background: HER2-directed antibodies (anti-HER2) are associated with cardiotoxicity and guidelines recommend routine cardiac monitoring. Recent studies suggest a wide range of card...
Abstract Sat306: External Validation of Out-of-Hospital Cardiac Arrest Outcome Prediction Models
Background: Inappropriate early neuroprognostication of out-of-hospital cardiac arrest (OHCA) patients may lead to inappropriate early withdrawal of life-sustaining treatments. Sev...
Abstract 4372620: Pulmonary Vascular Endothelial Dysfunction is Induced by Non-Pulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model
Background: Pulmonary vascular disease in patients with single ventricular heart disease (SVHD) following the partial cavalpulmonary connection (Glenn) is a significant source of m...
Abstract 4366947: Loeffler (Eosinophilic) Endocarditis Masquerading as Infective Endocarditis: Diagnostic Role of Multimodal Imaging
Background: Hypereosinophilic syndrome (HES) is a rare systemic condition characterized by persistent eosinophilia with potential cardiac involvement, manifesting as Loeffler endoc...
Abstract 4367053: <sup>18</sup> F-FDG PET/CT Evaluation of Incidental Extracardiac CT Findings on <sup>82</sup> Rb-Chloride PET Myocardial Perfusion Imaging
Background: Positron emission tomography (PET) combined with computed tomography (CT) is a valuable strategy for myocardial perfusion imaging (MPI) in ischemic heart disease evalua...
Abstract 4368224: Serial Myocardial Fibrosis Assessments Predict Outcomes in Patients with Hypertrophic Cardiomyopathy
Background: The prognostic value of serial myocardial fibrosis assessments in patients with hypertrophic cardiomyopathy (HCM) remains to be elucidated....
Abstract 4348778: Natural History and Outcomes of Massive Left Ventricular Hypertrophy in Childhood Hypertrophic Cardiomyopathy
Background: Massive left ventricular hypertrophy (mLVH) is a risk factor for sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy (HCM). However, little else is...
Abstract Sun107: Comparison of Foreign Body Airway Obstruction Interventions Among Laypersons: A Simulation-based, Crossover, Randomized Controlled Trial
Background: Foreign body airway obstruction (FBAO; choking) can quickly lead to respiratory arrest&death. As FBAOs occur in prehospital settings, survival depends heavily on by...
Abstract Sat303: Association of Metformin Use with Survival from Cardiac Arrest in the Emergency Department
Background: Metformin, an anti-diabetic oral medication with anti-inflammatory properties, has been shown in animal models to protect against ischemia-reperfusion injury post Cardi...
Abstract 4369008: Dual Therapy with Semaglutide and Physical Training Lowers Cardiorenal Burden in Experimental DKD and renal cells
Introduction: Diabetic kidney disease (DKD) is one of the most common complication of type 2 diabetes mellitus (T2DM) and confers increased risk of myocardial infarction, stroke, a...
Abstract 4359584: Utility of Continuous Wave Doppler Derived Rate of Pressure Rise (dp/dt) for the Assessment of Systolic Single Ventricular (SV) Function in Patients With Adult Congenital Heart Disease (ACHD)
Background: Staged palliation process for single ventricle (SV) patients alters preload, afterload, and ventricular mechanics, making accurate function assessment essential. Left v...
Abstract 4369605: Monoamine Oxidase-A Promotes Cardiomyocyte Senescence and Aggravates Diastolic Dysfunction in HFpEF via cGAS-STING Signaling
Background: Heart failure with preserved ejection fraction (HFpEF) involves myocardial aging, inflammation, and diastolic dysfunction. Monoamine oxidase-A (MAO-A), a mitochondrial...
Abstract 4358509: Vacuum-Assisted Debulking of Large Implantable Cardiac Device-Related Infective Vegetations With Concomitant Lead Extraction
Background: Large (>2 cm) vegetations related to cardiac implantable electronic device (CIED) infections carry a high risk of pulmonary embolism during transvenous lead extracti...
Abstract 4362570: Fatty Acid Metabolism and CPT2 Genotype May Influence Selexipag Responsiveness in Pulmonary Arterial Hypertension
Background: Selexipag is an established oral therapy for pulmonary arterial hypertension (PAH). In some patients, it enables withdrawal from continuous prostacyclin infusion. Howev...
Abstract 4363464: Fibrinolytic Debulking of a Large Left Ventricular Thrombus Prior to Emergent Valve-in-Valve Transcatheter Aortic Valve Replacement in the Setting of Critical Bioprosthetic Aortic Stenosis and Cardiogenic Shock
Description of Case: Left ventricular (LV) thrombus is generally a contraindication to transcatheter aortic valve replacement (TAVR) due to thromboembolic risk. However, non-surgic...
Abstract 4370673: STX-1150: A CRISPR-CasX Epigenetic Editor for Durable, Titratable LDLc Lowering
Background: Current LDLc lowering strategies, e.g., statins, ezetimibe, and PCSK9 inhibitors, offer variable efficacy (~30-60% reduction), limited durability (≤6 months), and varie...
Abstract 4367220: Time-updated spatial ventricular gradient orientation is associated with anthracycline-associated heart failure
Background: Anthracycline use is limited by cardiotoxicity resulting in heart failure (HF). The spatial ventricular gradient (SVG) is a vectorcardiographic (VCG) measurement of myo...
Abstract 4367914: Association of Angiotensin Receptor-Neprilysin Inhibitor Initiation With Mortality and Organ Failure Post Non-Acute Myocardial Infarction Cardiogenic Shock: A Multicenter Propensity Matched Retrospective Study
Introduction: Non-acute myocardial infarction (non-AMI) cardiogenic shock (CS) confers high mortality despite advances in therapy. Angiotensin Receptor-Neprilysin Inhibitor (ARNI)...
Abstract 4355624: Reperfusion Strategies For Medium And Distal Vessel Occlusion: A Systematic Review And Network Meta-Analysis.
Evidence on the most effective treatment for stroke due to distal and medium vessel occlusions (DMVOs) remains unclear, as existing meta-analyses compare heterogeneous groups. We conducted a network m...
Abstract 4365385: Microvesicles derived from human induced pluripotent stem cell-derived cardiomyocytes restore calcium homeostasis and improve post-infarction cardiac function in mice and swine
Background: Myocardial infarction (MI) is a leading cause of heart failure. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) show therapeutic potential for MI...