Circulation
Articles in this Issue
Abstract 4367946: Artificial Intelligence-Enabled ECG for Early Detection of Subclinical Atrial Fibrillation
Background: Silent (subclinical) atrial fibrillation (AF) is common and markedly raises stroke risk, yet it often evades standard screening that relies on symptomatic or incidental...
Abstract 4370521: Impact of the COVID-19 Pandemic on Cardiovascular Mortality Trends and Place of Death in Patients with Diabetes Mellitus (2018-2023): A Nationwide Analysis
Background: The COVID-19 pandemic disrupted healthcare systems and significantly impacted individuals with chronic conditions....
Abstract Sun408: Slower Rewarming Does Not Improve Neurological Outcomes After Cardiac Arrest: A Systematic Review and Meta-analysis of 906 Patients
Introduction: Rewarming after targeted temperature management (TTM) in cardiac arrest triggers complex physiological changes that may affect neurological recovery. Current guidelin...
Abstract Sun1005: Akt activation in leukocytes as a surrogate test for TAT-PHLPP9c efficacy
Introduction: We previously reported that TAT-PHLPP9c enhanced neurological intact survival in both murine and swine models of cardiac arrest. TAT-PHLPP9c is a 20-amino acid peptid...
Abstract 4343019: Cardiac magnetic resonance imaging findings and their association with exercise performance – data from the Single Ventricle Reconstruction Trial longitudinal follow-up
INTRODUCTION: In the Single Ventricle Reconstruction Trial, long-term follow up (SVRIII), morbidity and mortality compounded with age regardless of shunt type at Norwood procedure....
Abstract 4371345: Contemporary Use Of Parenteral Prostacyclin Administration In Pulmonary Artery Hypertension
Background: Group 1 pulmonary artery hypertension (PAH) is treated with three main drug classes: prostacyclin analogs (PCAs), endothelin receptor antagonists, and nitric oxide path...
Abstract 4364101: What Explains Differences in Statin Medication Adherence Among Individuals with Cardiovascular Disease? An Examination of Patient Characteristics, Clinical Relationships, and Area-Level Factors
Background: Statin medication can effectively manage some types of cardiovascular disease (CVD), but not everyone who could benefit from statins is taking them. While adherence to...
Abstract 4367886: Trends in Mortality from Valvular Heart Disease and Chronic Kidney Disease in the United States, 1999–2020: CDC WONDER analysis
Introduction Valvular heart disease and chronic kidney disease are significant causes of mortality in the U.S. Their evolving trends remain underexplored in recent decades. We aim...
Abstract 4368792: Extreme Temperatures are Associated with Hospital Admissions Across Central Massachusetts
Backround: Extreme weather and temperature can impact human health and influence acute care needs, particularly among older patients. Assessing for better metrics to measure extrem...
Abstract 4369184: Social Vulnerability and Outcomes Among Patients Hospitalized for Heart Failure with Reduced Ejection Fraction
Background: Deprivation indices are composite scores that capture regional variation in social determinants of health (SDH) and have been independently linked to healthcare dispari...
Abstract 4371034: Pathway between Food Access and Stroke: Targets for Intervention
Background: Food insecurity is associated with chronic disease and remains a key focus for population health interventions. Most research has focused on food insecurity at an indiv...
Abstract 4360395: Stroke and Myocardial Infarction Rates in Patients at High Risk for a First Major Atherosclerotic Cardiovascular Event: The VESALIUS-REAL Global Burden Study
Background: VESALIUS-CV (Effect of EVolocumab in PatiEntS at High CArdiovascuLar RIsk WithoUt Prior Myocardial Infarction or Stroke – CardioVascular; NCT03872401) is an ongoing cli...
Abstract 4367210: A Systematic Review and Meta-Analysis on the Anesthetic Approaches for Left Atrial Appendage Occlusion: Comparing Conscious Sedation and General Anesthesia
Background: Left atrial appendage occlusion (LAAO) provides a mechanical alternative to anticoagulation for stroke prevention in patients with nonvalvular atrial fibrillation. The...
Abstract 4359512: Purulent Pericarditis in a Patient with <i>Haemophilus influenzae</i> Bacteremia
Historically, purulent pericarditis was a recognized complication of bacterial infections, commonly due to pneumonia. However, with widespread antibiotic use it has become a rarity. It is defined as a...
Abstract 4365462: A Nationwide Italian Network for the Clinical and Genetic Diagnosis of Familial Dyslipidemias: The LIPIGEN registry
Introduction: Primary dyslipidemias represent a heterogeneous group of inherited disorders characterized by abnormal plasma levels of lipoproteins. Among them, familial hypercholes...
Abstract 4368472: Glucagon-Like Peptide 1 Mediated Reduction in Atrial Fibrillation Risk Is Independent of Weight Loss
Background: Glucagon-like peptide-1 (GLP-1) receptor agonists are known to have a protective effect on the risk of developing atrial fibrillation (AF). However, it is unknown if th...
Abstract 4371192: Intralipid Attenuates Myocardial Ischemia-Reperfusion Injury By Restoring Depletion of Branched-chain Amino Acids, Attenuating Mitochondrial Dysfunction, Inflammation, Apoptosis, and Oxidative Stress
Background: Myocardial ischemia-reperfusion injury (IRI) arises by abrupt myocardial blood flow restoration after ischemia leading to cardiomyocyte dysfunction and death. Mechanism...
Abstract 4370530: Protective Mechanisms Against Cardiac Toxicity of the EGFR Tyrosine Kinases Inhibitor Osimertinib
Introduction: Targeted therapies with Tyrosine Kinase Inhibitors (TKIs) have drastically improved the survival of cancer patients. However, long term exposure to TKIs has been asso...
Abstract 4351507: Older, non-White, Female and Uninsured Patients With a STEMI Are More Likely to be Transported to a non-Cardiac Cath Lab Center by EMS
Background: For patients with ST segment elevation myocardial infarction (STEMI), rapid access to primary percutaneous coronary intervention (PPCI) is critical, and guidelines reco...
Abstract 4373120: Assessment of Adverse Left Ventricular Remodeling Following Ischemia Reperfusion Injury with SPECT Imaging Agent Targeting Fibroblast Activation Protein
Background: While reperfusion significantly improves acute myocardial infarction (MI) survival rates, the process leads to an inflammatory cascade that upregulates fibrotic pathway...
Abstract 4369682: Association Between Microbubble Formation During Pulsed-Field Ablation and Asymptomatic Cerebral Infarction
Background: Pulsed-field ablation (PFA) has been introduced as a non-thermal energy source for atrial fibrillation (AF) ablation. However, a safety alert regarding cerebral infarct...
Abstract 4348297: Association Between Liberal Fluid Strategy and Postoperative Outcomes in Cardiac Surgery: A Systematic Review and Bayesian Meta-Analysis
Background: Fluid overload is increasingly recognized as a contributor to poor outcomes in critically ill patients, but its impact in the context of cardiac surgery remains underex...
Abstract Sun1308: Expanding a PulsePoint Deployment to Include Residential Alerts: Preliminary System Performance Characteristics
Introduction: PulsePoint is a mobile application that can notify volunteers about nearby out-of-hospital cardiac arrest events, allowing them to respond and provide cardiopulmonary...
Abstract 4357639: Reduction in Myocardial Infarct Size by GPR39 Inhibition Maybe Related to its Direct Tissue Effects
Background: We previously demonstrated that GPR39 is present in vascular smooth muscle cells (VSMCs) and pericytes in cardiac tissue. We also showed that genetic deletion of GPR39...
Abstract 4366136: Integrated Multi-Omics Analysis Reveals Suppressed Mitochondrial Fuel Metabolism in HFpEF Myocardium
Background: Heart failure with preserved ejection fraction (HFpEF) is a growing clinical challenge frequently associated with obesity and diabetes. While systemic metabolic abnorma...