Circulation
Articles in this Issue
Abstract 4371339: Frailty Tailored Mobile Integrated Health After Hospital Discharge: A Secondary Analysis of the MIGHTy Heart Randomized Clinical Trial
Background: Patients with heart failure (HF) who are discharged after an acute hospitalization are at high risk for 30 day readmission. Mobile Integrated Health (MIH), a program th...
Abstract 4344340: Obesity in Early Infancy Affects Left Heart Geometry and Function
Background: Obesity is associated with left atrial (LA) and left ventricular (LV) dysfunction, however, there is little information on when left heart structural and functional cha...
Abstract 4360905: Dietary Patterns Associated with Cardiovascular Resilience in Supercentenarians
Background: Supercentenarians (age 110 and above) and semi-supercentenarians (105~109) display extraordinary cardiovascular resilience. Yet, the dietary exposures underpinning this...
Abstract 4368336: Association between dietary inflammatory index and mortality in adults with hyperlipidemia: An analysis from the NHANES study
Background: The relationship between dietary inflammatory potential and mortality risk in individuals with hyperlipidemia remains underexplored. This study investigated the associa...
Abstract 4366102: Spatial- and attenuation-based epicardial adipose tissue features on CT calcium-score exams predict ASCVD events in immune-mediated inflammatory diseases
Background: Immune-mediated inflammatory diseases (IMID) such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and psoriasis increase atherosclerotic cardiovascula...
Abstract 4366527: Translational Analysis of Multi-Omics Informed Candidate Genes Identifies Potential Treatment Targets in Heart Failure with Preserved Ejection Fraction
Background: The development of effective treatments for heart failure with preserved ejection fraction (HFpEF) remains an urgent, unmet need. Multi-omics studies have identified nu...
Abstract 4369963: The Role of Sex-Specific Risk Factors in Sex Discordance unveiled by Artificial Intelligence-enhanced Electrocardiography: from the ELSA-Brasil study
Introduction: Artificial intelligence–enhanced electrocardiography (AI-ECG) models can accurately predict sex, and sex misclassification is associated with adverse cardiovascular (...
Abstract Sat606: Real-Time Geolocation Digital Platforms for the Availability of Automated External Defibrillators in Out-of-Hospital Cardiac Arrest: A Systematic Review
Background: Out-of-Hospital Cardiac Arrest (OHCA) is a leading cause of mortality worldwide, with survival heavily dependent on rapid Automated External Defibrillator (AED) access....
Abstract 4364602: Polygenic background for QT interval influences disease penetrance in individuals with genotype-positive congenital long QT syndrome
Background: Congenital long QT syndrome (LQTS) is characterized by a prolongation of the heart rate-corrected QT interval (QTc) and an increased risk of syncope, seizure and sudden...
Abstract 4373019: Multimodal Radiomics and Machine Learning for Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Meta-Analysis and External Validation
Background: Hemorrhagic transformation (HT) is a common outcome of acute ischemic stroke (AIS), especially following thrombolytic or endovascular reperfusion therapy. Early detecti...
Abstract 4367331: How Preload Influences Left Ventricular Volumetric Changes in Heart Failure with Preserved Ejection Fraction
Background: During exercise, many patients with heart failure with preserved ejection fraction (HFpEF) have an have impaired stroke volume response, which often attributed to incre...
Abstract 4366569: Proprotein Convertase Subtilisin/ Kexin Type 9 Inhibitors Improve Lipid Profile and May Stabilize Vasculopathy in Heart Transplant Recipients with Chronic Allograft Vasculopathy: A Pooled Analysis of Existing Studies
Introduction: Dyslipidemia plays a critical role in the progression of chronic allograft vasculopathy (CAV), which is a major cause of long-term graft failure and mortality in hear...
Abstract 4370092: Utilizing Machine Learning to Predict Uncontrolled Blood Pressure Status Among Adults with Hypertension
Introduction: Antihypertensive medication is effective at lowering blood pressure (BP). However, clinical inertia (i.e., failure of providers to increase the frequency or dose of a...
Abstract 4364127: Fatty Liver, Big Heart Risk: Prevalent Cardiovascular Risk among Young Children with Subclinical and Clinical Hepatic Steatosis
Background: Hepatic steatosis is closely linked to cardiometabolic risk factors (CMRF) in adults; however, less is known in childhood. In particular, data is lacking in younger chi...
Abstract 4370931: Impacts of perioperative cyclohexanone exposure on systemic inflammatory response
Background: Exposure to cyclohexanone, an industrial solvent used to soften medical plastics, has been associated with unfavorable outcomes for neonates undergoing congenital heart...
Abstract 4365599: A Population-based Multi-Scale Drug-Induced Cardiotoxicity Detection Platform
Background: The cardiotoxicity of drugs, which often leads to fatal arrhythmias such as torsade de pointes (TdP), is a major cause of drug recalls. The current detection of human e...
Abstract 4371332: A Novel ECG Time-Frequency Eyeball Method for Robust Detection of Myocardial Infarction from Single-Channel ECG: A Preclinical Study
Introduction: Myocardial infarction (MI) alters the heart’s electrophysiology, often seen as ST-segment deviation, T-wave inversion, or QRS distortion in electrocardiogram (ECG). W...
Abstract 4353276: Biomarkers of myocardial injury in community-based patients with suspected heart failure
Introduction: Myocardial injury is a hallmark of the syndrome of heart failure (HF). It is unknown whether established (e.g. troponin) or novel biomarkers of myocardial injury (e.g...
Abstract 4369004: Disparities in Age, Sex, Race, and Ethnic Representation in Coronary Artery Disease Clinical Trials in the United States
Introduction: Coronary artery disease (CAD) is estimated to affect 1 in 20 adults over the age of 20 in the United States (U.S.). Due to its profound public health impact, diverse...
Abstract 4368330: Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion Compared to Optimal Medical Therapy: A systematic review and meta-analysis
Introduction: Chronic total occlusion (CTO) is commonly encountered in patients with coronary artery disease and is associated with adverse outcomes, including increased short- and...
Abstract Or108: Divergent Biventricular Mechano-Energetic Responses to VA-ECMO Flow Ramping After Cardiac Arrest: A Preclinical ECPR Swine Model
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used in cardiac arrest (CA) resuscitation, yet its effects on biventricular mechanics remain...
Abstract 4369255: The Predictive Utility of Serial Graded Cardiac Response on Survival in AL Cardiac Amyloidosis: Real-World Data from a Large Amyloidosis Center
Introduction: AL cardiac amyloidosis (AL-CA) is marked by extracellular deposition of misfolded immunoglobulin light chains, leading to cardiac dysfunction and increased mortality....
Abstract 4347718: Trends in Atrial Fibrillation and Flutter Disability Adjusted Life Year Rates Attributable to Metabolic Risk Factors in The United States: An Analysis of the Global Burden of Disease, 1990-2021
Background: Atrial fibrillation (AF) and atrial flutter (AFL) are the most prevalent sustained cardiac arrhythmias globally, contributing to significant morbidity and mortality. Me...
Abstract 4357220: Serial Changes in Right Ventricular Volume in Patients with Tetralogy of Fallot: Insights from Longitudinal Cardiac MRI
Background: Advancements in congenital heart disease management have led to an increasing adult population with repaired Tetralogy of Fallot (rTOF). Serial imaging of Right Ventric...
Abstract 4370454: Pericarditis And Cardiac Tamponade As A Rare First Presentation Of Granulomatosis With Polyangiitis
A 28-year-old male with no chronic illness presented with pleuritic chest pain, progressive dyspnea, low-grade fever, and vomiting. Over days, he developed hemodynamic instability and worsening dyspne...