Circulation
Articles in this Issue
Abstract 4358524: The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci
Vascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the biological underpinning of vascular site-specific disease risk is largely unknown. Vascular tissues have different...
Abstract 4359002: Macrophage-Derived Legumain Enhances Extracellular Matrix Remodeling in Myxomatous Mitral Valve Degeneration.
Introduction: Myxomatous mitral valve degeneration (MMVD) is a prevalent cause of mitral valve regurgitation in developed countries, yet effective medical therapies targeting this...
Abstract 4354325: Impact of Social Determinants of Health on Cardiovascular and Maternal Outcomes in the Fourth Trimester: A 15-Year Comparative Outcomes Analysis Using Real-World Data
Background: Social determinants of health (SDOH), particularly adverse physical, housing, and environmental conditions, are increasingly recognized as key drivers of maternal and c...
Abstract 4367788: Myocarditis Mimicking a Lateral STEMI: A Façade by Flu-Associated Empyema
Background: Myocarditis can present with ST-segment elevations and rising troponin levels, mimicking an acute coronary syndrome. This case highlights a rare presentation of myocard...
Abstract 4367610: Effect Of SGLT2 Inhibitors On Cardiovascular Protection In Patients Undergoing Immune Checkpoint Therapy
Introduction: Immune checkpoint inhibitors (ICI) can trigger cardiac-related immune adverse effects by activating T cells against myocardial self-antigens, which can cause myocardi...
Abstract 4367273: Epigenetic Architecture of Abdominal Aortic Aneurysm and Its Augmented Risk in Smokers: Insights from Methylome-Genome Integration
Introduction: The methylomic mechanisms underlying abdominal aortic aneurysm (AAA) and the elevated risk observed in smokers remain poorly understood....
Abstract 4359763: Genetic determinants of left ventricular diastolic function
Background: Left ventricular (LV) diastolic function relies on active myocardial relaxation and passive cardiac chamber stiffness and is assessed by echocardiography. Abnormal LV d...
Abstract 4362041: Safety of Dofetilide Initiation Following a Shortened Amiodarone Washout Period
Background: Dofetilide, a commonly prescribed class III antiarrhythmic for atrial fibrillation (AF), currently requires a 3-month amiodarone washout period per FDA guidelines. We e...
Abstract 4362029: Endo-Epicardial Ablation for Recurrent Scar-Mediated Ventricular Tachycardia: A Case Report
Introduction: Endo-epicardial ablation is used for a wide variety of cardiac arrhythmias including idiopathic and scar-related ventricular tachycardias (VT). Patients who have exte...
Abstract 4365826: Tackling Socioeconomic Disparities in Access to TAVR in Low-Resource Settings: A Humanitarian Mission in the Dominican Republic
Background: Aortic stenosis remains a significant cause of morbidity and mortality worldwide. Transcatheter aortic valve replacement (TAVR) has become a transformative therapy for...
Abstract Sun402: Temperature Control After In-Hospital Cardiac Arrest: Outcomes from the Discover IHCA Cohort
Introduction: Temperature control is strongly recommended for comatose in-hospital cardiac arrest (IHCA) survivors. Variation in adherence and associations with outcomes have not b...
Abstract 4369083: Hepatic Steatosis and Subsequent Fibrosis Are Strongly Associated with Cardiometabolic Risk Clustering in Adults in the United States
Backround: Hepatic steatosis and hepatic fibrosis are systemic conditions that increase cardiometabolic risk. However, nationally representative data evaluating these associations...
Abstract 4365174: Toxic Heavy Metal Exposure and Heart Health: A Systematic Review and Meta-analysis of 324,331 Patients
Introduction: Heavy metal pollution, which contaminates water, soil, and food, particularly from arsenic, cadmium, lead, copper, and mercury, is a concerning cardiovascular risk fa...
Abstract 4370819: A Trickling Hourglass: A Case of Purulent Pericarditis and Liver Abscess Caused by Parvimonas micra
Introduction: Parvimonas is a part of the oral and gastrointestinal flora. It is a rare cause of purulent pericarditis and liver abscess. The literature has reported isolated cases...
Abstract 4362564: First-in-Human Clinical Application of Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patches for Non-Ischemic Dilated Cardiomyopathy
Background: Transplantation of induced pluripotent stem cell (iPSC)-derived cardiomyocytes has emerged as a novel therapeutic approach for severe heart failure. While clinical appl...
Abstract 4364346: Risk of Hospitalization in Patients with Heart Failure Exposed to Extreme Heat and Poor Air Quality in the Western United States
Introduction: Patients with underlying cardiovascular (CV) disease are vulnerable to adverse health events related to extreme weather. Limited data exist in those with heart failur...
Abstract 4359851: Low prevalence of coronary and thoracic aortic calcium in high-cardiometabolic risk Kenyan adults with and without HIV: The ASANTE Study
Background: HIV is thought to be an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), including coronary atherosclerosis, based on studies from high-incom...
Abstract 4367438: Evaluating Procedural Safety and Outcomes In GLP-1 Exposed Patients Undergoing TEE
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) like semaglutide and liraglutide are commonly used for type 2 diabetes, weight loss, and cardiovascular risk reduc...
Abstract 4366303: Feasibility, Acceptability, and Outcomes of a Two-group Randomized Controlled Pilot of a Gentle Yoga Intervention for Older Adults Post-Phase II Cardiac Rehabilitation
Background: Maintaining physical activity (PA) is essential to preserve cardiac health in older patients. Cardiac rehabilitation (CR) is commonly prescribed following acute cardiac...
Abstract 4365949: Artificial Intelligence-Driven Coronary Artery Calcium Scoring: An Opportunity Cardiologists Cannot Afford to Miss
Background: Coronary artery disease is the leading cause of mortality in the United States, affecting approximately 4.9% of adults. Coronary artery calcium scoring (CACS) is used t...
Abstract 4360742: Food Insecurity and Hypertension Among U.S. Women by Age Group: Results from the 2010-2023 National Health Interview Surveys
Introduction: Food insecurity is associated with an increased hypertension risk, and women are disproportionately affected by food insecurity compared to men. However, limited rese...
Abstract 4336116: Protein-Truncating Variants of the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Artery Disease among Patients with Heterozygous Familial Hypercholesterolemia
Backgrounds: Cholesteryl ester transfer protein (CETP) inhibition has long been attracting a lot of attention if it could reduce the risk for coronary artery disease (CAD). A previ...
Abstract 4358405: Risk for Central Sleep Apnea Remains High After Contemporary Heart Failure Guideline-Directed Medical Therapy
Introduction: Sleep disordered breathing (SDB) has been reported as a common comorbidity in heart failure (HF). Historic cohorts did not include patients using SGLT-2 inhibitors or...
Abstract 4365093: Identification and Functional Role of a Novel Macrophage Subset in Myocardial Infarction
Introduction: Myocardial infarction (MI) triggers complex inflammatory responses, during which myeloid cells, particularly macrophages, play pivotal roles in tissue healing and rem...
Abstract 4339657: Glucagon-Like Peptide-1 Receptor Agonists with Guideline Therapy Lower Mortality and Hospitalizations in HFpEF: A Propensity-Matched U.S. TriNetX Study
Background: Heart failure with preserved ejection fraction (HFpEF) in patients with type 2 diabetes and obesity is common and associated with high morbidity. Glucagon like peptide...