Circulation
Articles in this Issue
Abstract 4359112: Flecainide Reduces Exercise-Induced Arrhythmic Burden in PKP2-Related Arrhythmogenic Cardiomyopathy
Background: An increased burden of premature ventricular contractions (PVCs)/non-sustained ventricular tachycardia (NSVT) during the recovery phase of exercise stress testing (EST)...
Abstract 4366662: Itaconate stabilizes ABCA1 to regulate cholesterol burden: insights from targeting with lipid nanoparticles
Background/Aims: Itaconate (ITA) is a tricarboxylic acid cycle (TCA)-derived metabolite that limits atherosclerotic plaque growth and improves plaque stability via immunomodulation...
Abstract 4369022: A multi-task deep learning algorithm for detecting obstructive coronary artery disease using fundus photographs
Background and Aims: Obstructive coronary artery disease (CAD) can lead to myocardial infarction or cardiac death. The accuracy of conventional risk prediction models is limited, l...
Abstract 4369534: Differential associations of on-treatment average blood pressure (BP) control with cardiovascular outcomes in each vascular territory: Should we move beyond one-size-fits-all BP targets?
Background: Most BP guidelines suggest universal systolic BP (SBP) targets for reducing cardiovascular (CV) events. We hypothesised that the link between average mean SBP levels on...
Abstract 4373114: Signals of Cardioprotection with Colchicine in Takotsubo Cardiomyopathy: A Propensity-Matched Real-World Study
Background: Takotsubo cardiomyopathy (TCM), a transient myocardial disorder, is increasingly recognized to involve heightened inflammatory activation. Elevated inflammatory markers...
Abstract 4365855: Two-Decade Trends in Mortality Due to Atrial Fibrillation Among Older Adults With Heart Failure in the United States (1999–2023)
Context: Atrial fibrillation (AF) and congestive heart failure (CHF) commonly coexist in older adults, significantly increasing morbidity and mortality. However, long-term trends i...
Abstract 4363060: LMNA <sup>R541C</sup> Mutation Lead to Dysregulation in Metabolism and Proliferation Pathways in Cardiomyocytes
Background: The LMNA gene codes for lamin A/C, a nuclear structural protein with wide expression. Pathogenic Variants (PVs) in...
Abstract 4367443: Who Can Safely Stop Anticoagulation Following Left Ventricular Thrombus Resolution
Background: Whether oral anticoagulation (OAC) can be discontinued after the resolution of left ventricular thrombus (LVT) remains controversial, particularly in patients without r...
Abstract 4359147: Uncovering Cellular and Molecular Mechanisms in Fontan-Associated Liver Disease
Introduction: Nearly 1 in 10,000 infants are born with a single ventricular heart, and these children must undergo the Fontan procedure to survive. As of 2020, an estimated 50,000...
Abstract 4346280: Atovaquone Attenuates Hypertrophic Cardiomyopathy via MARCH3-Mediated GP130 Degradation
BACKGROUND: Hypertrophic cardiomyopathy (HCM), affecting approximately 1 in 500 individuals globally, is a leading cause of sudden cardiac death in young adults. Current treatments...
Abstract 4366450: Underrepresentation of sex and race/ethnicity in ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Background: Despite the significant impact of race and gender on diagnosis, treatment, and outcomes in cardiovascular care, these groups remain underrepresented in the literature....
Abstract 4358422: Comparative Efficacy and Safety of Renal Denervation Versus Spinal Cord Stimulation in Hypertensive Patients: A Propensity-Matched Cohort Study
Introduction: Hypertension remains a leading contributor to cardiovascular morbidity and mortality despite advances in pharmacotherapy and device-based interventions. Renal denerva...
Abstract 4370032: Cardiac and renal expression of angiotensin II type 1 receptor and its association with fibrosis and heart function in ischemic heart failure rat models
Introduction: Despite the growing interest in the role of Angiotensin II type 1 receptor (AT 1 R) in left ventricular remodeling and heart f...
Abstract 4367346: High-Dose Adenosine Priming Facilitates Successful Metoprolol Conversion of Refractory AVNRT in Late-Term Pregnancy
Introduction: Management of tachyarrhythmias during pregnancy, particularly atrioventricular nodal reentrant tachycardia (AVNRT), presents unique challenges due to concerns regardi...
Abstract 4370478: Effectiveness of Mobile Medical Clinics in Blood Pressure Control in Low Resource Settings
Background: In low-resource settings, limited healthcare access contributes to uncontrolled hypertension and elevated cardiovascular risk. Mobile medical clinics (MMCs) offer a pot...
Abstract 4366794: Comparable Outcomes in Direct Impella Use Versus Intra-Aortic Balloon Pump-to-Impella Escalation Strategy in Cardiogenic Shock
Introduction: Impella and IABP are widely used temporary mechanical circulatory support (tMCS) devices in cardiogenic shock (CS). While Impella can be used as the initial support d...
Abstract 4340599: The Novel Muscle-specific RING Finger-2 Target Sorting Nexin 5 Regulates Protein kinase A Activity through Stabilization of Protein Kinase A Regulatory Subunit Type Iα and Controls Myogenic Differentiation
Background: Muscle RING finger (MuRF) proteins are E3 ubiquitin ligases crucial for maintaining striated muscle homeostasis. MuRF1 is well known for its role in muscle atrophy, whi...
Abstract 4367957: Transapical beating-heart septal myectomy for symptomatic nonobstructive hypertrophic cardiomyopathy: Achieving structural relief and functional recovery
Introduction: The pathogenesis of nonobstructive hypertrophic cardiomyopathy (nHCM) involves a combination of systolic cavity obliteration with reduced stroke volume, midventricula...
Abstract 4369029: Regional and Temporal Mortality Trends of Congenital Cardiovascular Malformations in Patients with Chromosomal Abnormalities in the United States from 1999 to 2020
Background: Congenital cardiovascular malformations (CVMs) affect 0.5 to 0.7% of all live born infants. Chromosomal abnormalities (CA) both increase CVM severity and contribute to...
Abstract 4361575: Phenotyping Cardiogenic Shock Using Unsupervised Machine Learning: A Nationwide Cluster Analysis from National Inpatient Sample
Introduction: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, with varied clinical outcomes driven by hemodynamic states, and initial presentation. However, unsupervis...
Abstract 4340240: Inflammation as a driver of arrhythmogenic cardiomyopathies; insights from the buccal epithelium
Background information: Despite decades of research, diagnosis and management of arrhythmogenic cardiomyopathies (ACM) remain challenging owing mostly to poor understanding of dise...
Abstract 4368642: Progressive Myocardial Flow Reserve Impairment Across Cardio-Kidney-Metabolic Syndrome Stages Predicts Cardiovascular Risk: Insights from Cardiac PET
Background: Cardio-Kidney-Metabolic (CKM) Syndrome represents a progressive multisystem disorder associated with increasing cardiovascular risk. However, the evolution of coronary...
Abstract 4335849: Improvements in Diagnostic and Therapeutic Cardiovascular Risk Assessment Through Total Plaque Volume Burden: An Analysis of the Fish&Chips Study
Background: Quantitative coronary plaque analysis from coronary computed tomographic angiography (CCTA) is a promising strategy for individualized cardiovascular disease (CVD) prev...
Abstract 4362160: Validation of Ring-Type Cuffless Blood Pressure (BP) Monitoring Device for Detecting Awake-Asleep BP Variations Compared to Ambulatory BP Monitoring Device
Introduction: Based on recommendations for validating cuffless BP devices by the European Society of Hypertension (ESH), this is the first validation study assessing the accuracy o...
Abstract 4368954: Direct Oral Anticoagulants or Warfarin in Left Ventricular Thrombus: a Systematic Review and Meta-Analysis of Randomized Trials
Background: Left ventricular thrombus (LVT) is a significant complication following acute myocardial infarction (AMI), posing substantial risks of stroke and systemic embolism. War...