Circulation
Articles in this Issue
Abstract 4368701: Microvascular Endothelial Heterogeneity in Canonical Tissues of Human Insulin Resistance Identifies Depot Specific ER Stress as a Novel Therapeutic Target
Introduction: Endothelial cell (EC) heterogeneity across vascular beds and disease states is increasingly recognized. However, tissue-specific EC heterogeneity in individuals with...
Abstract Sat301: Plasma Glutamate, Early Neurological Risk Stratification, and Outcome: A Post-hoc Analysis of the PROTECT Trial
Introduction: Prophylactic antibiotics can reduce infections after acute brain injury; Ceftriaxone (CTX) also modulates glutamate (GLUT) transporter function, which may reduce exci...
Abstract 4369261: Virtual Home-based Exercise Improves Functional and Fitness Outcomes in Veterans with Peripheral Artery Disease: The Smart MOVE Study
Background: Approximately 8.5 million US adults and 10% of veterans suffer from peripheral artery disease (PAD), the primary symptom of which is reproducible leg pain with walking...
Abstract 4365718: Artificial Intelligence–Enabled Electrocardiography for Detecting Risk of Rehospitalization in patients with Heart Failure
Background: Preventing and managing hospital readmissions is critical in heart failure (HF) care, yet conventional monitoring tools have limitations. While artificial intelligence-...
Abstract 4364823: Optimizing AV Nodal Ablation: The Role of Coronary Dominance in Procedural Planning
Background: The atrioventricular node artery supplies the atrioventricular node (AVN) and exhibits variability in origin and course as it may originate from the right coronary arte...
Abstract 4369205: Atrial Fibrillation and cardiomyopathy risk post-chemotherapy in breast cancer patients: Insights from the All of Us Research Program
Background: Chemotherapy is associated with increased cardiovascular risk in breast cancer patients, yet the influence of racial and ethnic disparities on atrial fibrillation (Afib...
Abstract 4369756: Blood Lead Levels and Their Association with Cardiometabolic Outcomes in Adolescents: Preliminary Findings from the National ECHO Cohort
Background: Despite declines in environmental lead exposure, it remains a significant public health issue, particularly for children and adolescents in low-income and minority comm...
Abstract 4368483: Low Dose Rivaroxaban Plus Aspirin Improves Cardiovascular Outcomes and Reduces Mortality in Coronary Artery Disease
Introduction: Coronary Artery Disease (CAD) is the most common type of heart disease and remains a leading cause of mortality worldwide. An estimated nine million people die from c...
Abstract 4345107: Gender disparities of the modified HEART score in acute chest pain in emergency department: insight from a multicenter, randomized controlled trial
Background: HERAT score has been acknowledged as a useful tool stratified risk among patients with acute chest pain in emergency department (ED). This study aims to explore the gen...
Abstract 4371270: Prognostic Utility of Exercise Pulmonary Artery Pulse Pressure in Ambulatory Patients with Heart Failure with Preserved Ejection Fraction
Introduction: Exercise testing has been proven to improve phenotypic resolution and risk stratification in patients with heart failure with preserved ejection fraction (HFpEF). We...
Abstract 4371412: Cardiac dysfunction in a preclinical model of Autosomal Dominant Polycystic Kidney Disease
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder caused by dominant mutations in either the PKD1 or...
Abstract 4355631: Comparison of SPECT/CT Quantification to Planar Heart-to-Contralateral Ratio of 99mTc-Pyrophosphate CT Scans for Prediction of Heart Failure Hospitalization in Patients with Transthyretin Cardiac Amyloidosis (ATTR-CA)
Background: ATTR-CA is associated with heart failure (HF) and premature death. It is diagnosed non-invasively with radionuclide imaging, most commonly using 99mTc-pyrophosphate (PY...
Abstract 4370994: Utilization of Patient Wearable Technology to Monitor the Health of Patients with Hypertrophic Cardiomyopathy: A Pilot Study
Background: Advances in wearable technology have enabled real-time monitoring of arrhythmias and patient health metrics. However, feasibility and clinical utility of such devices f...
Abstract 4370962: Greater Neighborhood Resources Predict Reduced In-Hospital Mortality for Children with Heart Failure
Background: Patients with pediatric heart failure (HF) face significant morbidity and mortality. However, there are limited data describing neighborhood characteristics in pediatri...
Abstract 4371477: Discordance Between CAC Scoring and PREVENT Risk Estimates in Primary Prevention
Background: CAC scoring is a validated tool in primary prevention that stratifies cardiovascular risk and guides treatment decisions. The PREVENT algorithm uses clinical and sociod...
Abstract Sat1201: Sequence of Epinephrine Administration and Advanced Airway Management for Adult Patients with Out-of-Hospital Cardiac Arrest
Introduction: Epinephrine administration and advanced airway management (AAM) (i.e., supraglottic airway insertion or endotracheal intubation) are commonly performed prehospital in...
Abstract 4366943: Oral Health in Children and Adolescents With and Without Heart Disease in the United States 2022-2023
Background: Children and adolescents with heart disease (HD) represent a vulnerable population with an increased risk for dental caries and periodontal issues resulting in poor ora...
Abstract 4367091: Impact of Aspirin on Prevention of Peripartum Cardiomyopathy in Women With Pregnancy-Related Hypertensive Disorders
Background: Pregnancy-related hypertensive disorders are major risk factors for peripartum cardiomyopathy (PPCM). Although aspirin is recommended during pregnancy to reduce the ris...
Abstract 4363949: Endogenous C-type natriuretic peptide maintains cardiac structure and function in heart failure with preserved ejection fraction
Introduction: C-type natriuretic peptide (CNP) is an endogenous paracrine mediator released by endothelial cells and cardiomyocytes during inflammation and cardiac stress. CNP is k...
Abstract 4369238: THRV-1268, a potent and selective serum and glucocorticoid regulated kinase (SGK1) inhibitor, improves adverse cardiac remodeling better than Jardiance® (empagliflozin), a sodium-glucose cotransporter 2 (SGLT2) inhibitor in heart failure
Introduction: SGLT2 inhibitors improved clinical outcomes in patients with heart failure (HF), highlighting metabolism-related pathways as a therapeutic target. Genetic inhibition...
Abstract 4371131: Trends in Angina and Heart Attack Prevalence by Sex, Region, and Social Vulnerability Among U.S. Adults (2019–2023)
Background: Angina and myocardial infarction (MI) are major contributors to cardiovascular morbidity and mortality. We assessed recent trends in angina and MI prevalence by sex, re...
Abstract 4359808: <i>Missed Opportunities for Antemortem Detection of Cardiac Amyloidosis: An Autopsy-Based Retrospective Evaluation of Screening Recommendations</i>
Background: Cardiac amyloidosis (CA) remains underdiagnosed, partly due to variability in screening recommendations. Current criteria suggest screening for CA at a left ventricular...
Abstract 4373687: Robust EEG Functional Connectivity Metrics for Decoding Action Observation Conditions and Observed Actions
Background: Reliable EEG biomarkers of brain-network engagement could personalize action-observation (AO) therapy after stroke....
Abstract 4363274: Evolutionarily Conserved Signatures of Adaptive Right Ventricular Remodeling
Background: Right ventricular failure (RVF) has a high mortality risk across multiple heart diseases, has no proven therapies, and has few identified candidate targets suitable for...
Abstract 4369111: Extracellular miR-150 Released by hAMSC in Response to Ischemia/Reperfusion Injury Identifies a Novel Target for Myocardial Repair
Introduction: Human amniotic mesenchymal stem cells (hAMSC) possess substantial therapeutic potential in hepatic, oncological, and degenerative disorders; however, their role in ca...