Circulation
Articles in this Issue
Abstract 4362366: Left Atrial Reservoir Strain and Clinical Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from the HELIOS-B Trial on Vutrisiran Efficacy
Introduction: Amyloid infiltration of the atria and cardiac remodeling in response to elevations in intracardiac filling pressures lead to atrial dysfunction in patients with trans...
Abstract 4363365: Toward Eliminating Bupivacaine’s Cardiotoxicity
Introduction: Bupivacaine (BPV) is a lipophilic local anesthetic (LA) that blocks voltage-gated sodium channels (Na v ) to prevent pain and...
Abstract 4369971: A Hemodynamic Warning Sign: Continuous Mitral Regurgitation and Normal Sinus Rhythm
Introduction: Continuous mitral regurgitation (MR) is a rare echocardiographic finding. Diastolic MR, although uncommon, is typically associated with atrioventricular (AV) dissocia...
Abstract 4370038: Myocardial Tuberculosis Presenting as Ventricular Tachycardia Along with Heart Failure Mimicking Sarcoidosis: A Case Report
Background: Myocardial tuberculosis (TB) is an extremely rare form of extrapulmonary TB with a reported prevalence of less than 2%. It is often diagnosed late due to subtle systemi...
Abstract 4368682: Two-year Outcomes for Women in the 5-year SMART Trial
Background: The Small Annuli Randomized To Evolut or SAPIEN Trial (SMART, NCT04722250; Medtronic funded) compares the performance of Evolut and SAPIEN transcatheter aortic valve re...
Abstract 4370906: Temporal Sequence of Mitral Valve Disease and Atrial Fibrillation Impacts Cardiovascular Outcomes
Background: Atrial fibrillation (AF) and mitral valve regurgitation (MVR) often co-occur in clinical settings, with the temporal sequence of their diagnoses potentially influencing...
Abstract 4344599: Converging Mechanisms in Divergent Cardiomyopathies: FSCN1 as a Druggable Epigenetic-Mitochondrial Target in Heart Failure
Background: Heart failure (HF) is the final common outcome of diverse cardiomyopathies (CMys), including dilated (DCM), ischemic (ICM), and hypertrophic (HCM), and remains a major...
Abstract 4360117: Pulse Oximetry and Skin Tone in Children (POSTer-Child): A validation study
Introduction: Recent retrospective studies have found overestimation of oxygen saturation by pulse oximetry in races with darker skin tone. Existing studies have used race as a poo...
Abstract 4367215: Beyond the Apex: Redefining High-Risk Phenotypes in Apical Hypertrophic Cardiomyopathy
Background: Apical hypertrophic cardiomyopathy (ApHCM) with left ventricular apical aneurysm represents a newly recognized high-risk phenotype. The 2020 AHA/ACC guidelines establis...
Abstract 4361118: Fibroblast-Derived CLEC11A Drives Pathological Cardiac Hypertrophy and Fibrosis
Background: Cardiac hypertrophy can be either physiological or pathological. Physiological hypertrophy, typically induced by exercise, is adaptive and associated with minimal fibro...
Abstract 4367044: Cerebral Infarction Mortality Trends in Older Adults in the United States From 1999 to 2020
Background: Stroke is the 5 th leading cause of death in the United States and an estimated 160,000 people die annually from it according to...
Abstract 4369050: Eicosapentaenoic Acid (EPA) and GLP-1 Receptor Agonist Combination Enhanced Expression of Src Kinase and Related Pathways in Endothelial Cells during Inflammation
Background: The Src family of non-receptor protein tyrosine kinases participate in numerous cell-signaling pathways, including cell-cell and cell-extracellular matrix interactions....
Abstract 4358117: Hyperoxia During Cardiopulmonary Bypass in Neonatal Congenital Heart Surgery is Associated with Worse Clinical Outcomes: A Multi-Institutional Study
Background: Neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB) may be exposed to supraphysiologic oxygen (O 2 ) concentra...
Abstract 4368775: Feature Tracking Global Longitudinal Strain Enhances Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy
Background: Left ventricular global longitudinal strain (LV-GLS) assessed by cardiac magnetic resonance feature tracking (CMR-FT) is an emerging marker for predicting adverse outco...
Abstract 4366502: Graduation from a Nurse Practitioner-led, Team-Based Cardiovascular-Kidney-Metabolic Clinic Improves Cardiovascular-Kidney-Metabolic Health and is Associated with Hospitalization Reduction: Initial Experience in an Academic Community Practice
Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome, defined as the interplay of metabolic and kidney disease on cardiovascular conditions, is widely prevalent. Novel drug c...
Abstract 4354316: Artificial Intelligence Based CCTA to Assess Sex-Based Differences in Coronary Atherosclerosis with Low Clinical Atheroma Volume
Background: Traditional calcium-based risk assessment tools may underestimate coronary artery disease (CAD) burden, particularly in females, due to their inability to capture non-c...
Abstract 4362331: Prevalence and Predictors of Left Ventricular Systolic Dysfunction during Treatment with Mavacamten for Obstructive Hypertrophic Cardiomyopathy
Background: Mavacamten is effective at improving symptomatic left ventricular outflow obstruction in patients with hypertrophic cardiomyopathy (HCM). Its main adverse effect is lef...
Abstract 4365943: p38β Systemic Genetic Deletion Exacerbates Structural and Electrophysiological Remodeling in the Aging Heart
Introduction/Background: Aging is a significant risk factor for cardiac pathologies, such as heart failure, arrhythmias, and myocardial infarction. p38 MAPKs regulate cardiac remod...
Abstract 4366364: Identification of biomarkers associated with MASLD among CVD patients
Background: MASLD is a liver disease defined by fat accumulation not caused by alcohol. It is closely associated with metabolic conditions like diabetes and obesity. In the U.S., i...
Abstract 4358325: Performance of a cuffless photoplethysmography-based device for continuous monitoring of blood pressure
Introduction: Blood pressure (BP) is a complex physiological marker. Cuffless devices, often based on photoplethysmography (PPG), enable frequent or continuous BP monitoring withou...
Abstract 4341281: Chronic kidney disease in US adults with uncontrolled hypertension: prevalence, characteristics, and mortality, an NHANES analysis
Introduction: The prevalence of uncontrolled hypertension (HTN) remains high in the United States (US), despite the availability of multiple oral antihypertensive medications. Give...
Abstract 4370075: Leveraging Single-Nucleus Chromatin Accessibility and Transcriptome Profiling to Define the Regulatory Landscape of Dilated Cardiomyopathy
Introduction: While genetic variants linked to dilated cardiomyopathy (DCM) are increasingly well characterized, the molecular mechanisms driving pathogenesis remain poorly underst...
Abstract 4368508: Cardiac chambers remodeling in patients with atrial fibrillation and spontaneous cardioversion
Introduction: In atrial fibrillation (AF), few studies have focused on the influence of the mode of cardioversion (CV), spontaneous (SpCV) versus non spontaneous (noSpCV) on cardia...
Abstract 4362777: Predictors of Left Atrial Compliance and V-Wave Response in Transcatheter Mitral Valve Therapy
Background: Severe mitral regurgitation (MR) is typically associated with large V-waves on invasive hemodynamic monitoring. However, discrepancies often arise between echocardiogra...
Abstract 4370861: Climate Change and Cardiovascular Disease: A Systematic Review of Environmental Stressors and Cardiovascular Outcomes
Background: Climate change poses a growing threat to global cardiovascular health. Environmental stressors such as rising temperatures, air pollution, and extreme weather events ma...