Circulation
Articles in this Issue
Abstract 4366313: SGLT-2 Inhibitors Reduce Mortality and Heart Failure Hospitalizations Following TAVR in Severe Aortic Stenosis: A Meta-Analysis
Introduction/Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce cardiovascular morbidity and mortality in patients with heart failure and type 2 diabetes. Howeve...
Abstract 4345980: Noise-Induced Stress Amplifies Inflammation through NLRP3 Inflammasome Activated by Endoplasmic Reticulum Stress in the Mouse Hearts
Introduction: Noise exposure is increasingly recognized as a significant contributor to cardiovascular disease (CVD). Clinical and epidemiological studies have demonstrated that no...
Abstract 4367150: Utilizing Virtual Reality for Pre-Transplant Planning in Patients with Congenital Heart Disease
Backround: Virtual reality (VR) has emerged as a powerful tool in the pre-procedural planning of complex congenital heart disease (CHD), enabling enhanced visualization of anatomy...
Abstract 4372725: CHAPERONE: Cardiovascular Kidney and Metabolic (CKM) Health Assessment and Patient Empowerment in chROnic Disease using a Health Coach iNtervention ModEl: A Randomized Clinical Trial Design Authors: Krishnaswami Vijayaraghavan, Navin Govind, Pat Dunn, Zaki Lababidi, Shishir Murarka, Sun Jones, Kevin Shah, Devendra Wadwekar, Marcus Stahlberg, Edgar Lerma, Dinesh Kalra, Keyvan Koochek, Lakshmi Nair, Samer Ibrahim, Jordi Livi, and Randal Schulhauser
Background: The interconnectedness between Cardiovascular Kidney and Metabolic(CKM) diseases has been increasing in its importance, morbidity, mortality, and economic burden. There...
Abstract 4359177: In-Hospital Cardiac Arrest Is Associated With Higher Mortality Than Out-of-Hospital Cardiac Arrest in Patients With Cardiac Arrest Treated With eCPR
Background: Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly being used for cardiac arrest refractory to conventional resuscitation. While data suggests the bene...
Abstract 4367372: Hidden Heart Disease Uncovered: The power of community-based echo screening program - A Case Report from the Every Heart Matters Program
Introduction: Access to cardiovascular diagnostics remains a major barrier to equitable care, particularly among underserved populations. In alignment with ASE, ACC, and AHA recomm...
Abstract 4365543: Acoramidis Reduces the Risk of All-Cause Mortality and Cardiovascular-Related Hospitalization Compared With Placebo in Participants With Transthyretin Amyloid Cardiomyopathy and Early-Stage Heart Failure Regardless of Atrial Fibrillation History: Insights From ATTRibute-CM
Background: Atrial fibrillation/flutter (AF/AFL) is a common complication of transthyretin amyloid cardiomyopathy (ATTR-CM) that can impact quality of life even in early-stage dise...
Abstract 4360739: Severe Hypertriglyceridemia in Pregnancy: A Case Highlighting Therapeutic Challenges
Introduction: Severe hypertriglyceridemia (HTG) in pregnancy increases the risk of acute pancreatitis and preeclampsia, carrying a high maternal and fetal mortality rate. Managemen...
Abstract 4358966: Effectiveness of a Mobile Integrated Health vs Transitions of Care Coordinator in Heart Failure: Results from the MIGHTy-Heart Trial
Background: Hospital-to-home transitions are high-risk for patients with heart failure (HF). The MIGHTy-Heart pragmatic randomized clinical trial compared a Mobile Integrated Healt...
Abstract 4369047: Genome-wide analysis of human lipidome identifies new metabolite QTLs linked with diabetes and cardiovascular disease in Asian Indians and Europeans
Background: Despite the achievements of genome-wide association studies (GWAS), the genetic mechanisms that predispose individuals to type 2 diabetes (T2D) and its cardiovascular (...
Abstract 4346161: Using an Algorithm-based Decision Support Tool to Identify the Most Likely Source of Dyspnea in Patients With Heart Failure Presenting to the Emergency Department
Background: Dyspnea is a common yet diagnostically challenging complaint at emergency department (ED) triage, particularly in patients with heart failure (HF). We sought to develop...
Abstract 4356768: Association of Unemployment Rates and Cardiovascular Disease Mortality in Northeast United States
Introduction: Unemployment increases the likelihood of cardiovascular disease mortality (CVDM) for middle-aged men in high-income nations. In the United States, both CVDM and unemp...
Abstract 4373333: Inverse Association Between Educational Attainment and Cardiovascular Mortality: A Nationwide Investigation from the United States in 2022
Background: Educational attainment is a key social determinant of health. However, the extent to which cardiovascular mortality rates differ by education level in the contemporary...
Abstract 4367051: A novel deep learning framework identified associated genes and Interpretable deep learning translation of GWAS findings for drug repurposing in Atrial Fibrillation
Introduction: Translating human genetic findings, such as genome-wide association studies (GWAS) to pathobiology and the discovery of therapeutic target remains a challenge for Atr...
Abstract 4359809: Effect of Subcutaneous (SC) Injection of Furosemide Compared with Intravenous (IV) Injection on Vital Signs in Healthy Volunteers
Introduction: Furosemide (FUR) remains the cornerstone agent to decongest patients with heart failure. Given the challenges associated with intravenous (IV) administration, an 80mg...
Abstract 4371746: Comparative Study of Cardiovascular Safety of GLP-1 Receptor Agonists Across Indications: A Meta-Analysis of Randomized Controlled Trials in Type 2 Diabetes and Obesity
Background: Cardiovascular disease is a leading cause of death globally, with type 2 diabetes (T2DM) and obesity as major contributors.GLP-1 receptor agonists (GLP-1 RAs) have demo...
Abstract 4372587: Plasma-Primed Pericyte-Derived Extracellular Vesicles Enhance Angiogenic Responses and Promote Recovery in Ischemic Limb Tissue
Introduction: Peripheral artery disease (PAD) is marked by reduced limb blood flow due to atherosclerosis, often leading to ischemia, non-healing wounds, or limb loss. Pericytes ar...
Abstract 4370155: Comparison of baseline EKG parameters between the first and second Heart xenotransplant
Background: The 1 st and 2 nd genetically modified porcine-to-human cardiac xenotransplantations wer...
Abstract 4358212: Protective Effect of Renin–Angiotensin–Aldosterone System Inhibitors Guided by Artificial Intelligence–Enabled Electrocardiograms on Incident Left Ventricular Dysfunction: A Multicenter Cohort Study
Background: Artificial intelligence–enabled electrocardiogram (AI-ECG) models can accurately detect left ventricular dysfunction (LVD), and their misclassification in patients with...
Abstract 4358409: RNA INTERFERENCE OF ANGPTL3 VIA ZODASIRAN: A NEXT-GENERATION APPROACH FOR TREATING ATHEROGENIC DYSLIPIDEMIA
Introduction: Atherogenic dyslipidemia contributes to residual cardiovascular risk despite current therapies. ANGPTL3 inhibition is a novel approach to reduce atherogenic lipids. Z...
Abstract 4357893: Cardiovascular Adverse Events with Venetoclax-Based Treatment in Acute Myeloid Leukemia
Introduction: Venetoclax, a BCL-2 antagonist, is a novel anti-neoplastic agent used in various hematologic malignancies, including acute myeloid leukemia (AML). The aim of the curr...
Abstract 4369126: Clinical Improvements from Remote Patient Monitoring Regress After Discontinuation and Resume Upon Reinitiation
Background: Remote patient monitoring (RPM) is used to manage hypertension, but its long-term effects, especially after breaks in monitoring, are not well characterized. It remains...
Abstract Sat905: Two-Year Growth and Evaluation of an Online Support Community for All Those Affected by Cardiac Arrest
Introduction/Background: Cardiac arrest survivors often experience physical, cognitive, emotional, and social challenges that can linger for years. Co-survivors and lay responders...
Abstract 4370143: Plaque Eccentricity and Delayed Flow as Predictors of Vulnerable Lesions in Unstable Angina: Insights from Dynamic Angiography, IVUS, and Deep Learning for Personalized Management
Background: In coronary hemodynamics, laminar flow is a protective mechanism, and turbulent flow is a detrimental factor. In clinical practice, for patients with unstable angina, t...
Abstract 4369619: Single-Cell Resolution Spatial Transcriptomics Reveals Cellular and Molecular Dysregulation in Human Pulmonary Arterial Hypertension
Background: Lung tissue exhibits intricate spatial organization and dynamic cellular interactions. However, the molecular mechanisms underlying pulmonary arterial hypertension (PAH...