Circulation
Articles in this Issue
Abstract Sun403: High Quality Temperature Control Is Associated with Improved Outcome following Out-of-Hospital Cardiac Arrest
Introduction: The neuroprotective benefit of hypothermic temperature control (TC) has not consistently translated into clinical practice. We previously defined high quality (HQ) TC...
Abstract 4364434: Single Gene Plasmid Expressing Multiple C-terminal Gα Inhibitory Peptides Targeting Parasympathetic and Sympathetic Signaling in the Atria Prevents Atrial Fibrillation in a Canine Model
Introduction: Atrial fibrillation (AF) is the most common arrhythmia and is a major risk factor for stroke. Existing therapies including ablation remain suboptimal. An increase in...
Abstract Sat605: Changing relative distribution of out-of-hospital cardiac arrest cases by sex
Background: The incidence of out-of-hospital cardiac arrest (OHCA) varies by sex with a higher incidence reported in males. Nationally, >60% of OHCA cases are male. However, lon...
Abstract 4338158: The metabolome is preserved in failing mouse hearts but shifts under additional stress
The healthy heart is omnivorous as it readily utilizes fatty acids, glucose, lactate, pyruvate, ketone bodies, and amino acids. This adaptation enables the heart to metabolize alternative fuels when t...
Abstract 4344211: Testing the Feasibility, Usability, Acceptability, and Effect of a Generative AI-Based Sleep Intervention
Background: Poor sleep is a concerning public health problem in the U.S. To address this issue, we developed a prototype sleep intervention powered by advanced artificial intellige...
Abstract 4365710: Epidemiology of Suspected Sudden Cardiac Death in the Young
Background: The incidence estimates of sudden cardiac death in young people vary widely, ranging from 0.7-10 cardiac deaths per 100,000 persons. The NIH/CDC Sudden Unexpected Infan...
Abstract 4371134: Adverse Cardiovascular Health Impacts Associated with Fossil-fuel-related Source-specific Particulate Matter Particles
Past epidemiological evidence for the causal link between cardiovascular disease (CVD) and fine particulate matter (PM 2.5 ) particles have focused on overall m...
Abstract 4360277: Primary non-adherence and patterns of underutilization of guideline-directed medical therapy following hospitalizations for myocardial infarction
Background: Guideline-directed medical therapy (GDMT) following a myocardial infarction (MI) is crucial for secondary prevention. Prescription of GDMT is emphasized at hospital dis...
Abstract 4367441: X-Chromosome-Wide Association Study Identifies Novel Heart Failure Risk Loci with Sex- and Subtype-Specific Effects
Background/Aims: Heart failure (HF) is a leading cause of cardiovascular morbidity and mortality, with notable sex differences. Although the lifetime risk of HF is similar between...
Abstract 4369352: Lipoprotein (a) [Lp(a)] levels are not associated with MACE outcomes in patients with suspected CAD referred for Cardiac PET/CT stress tests in an integrated health system
Background: Lipoprotein (a), or Lp(a), is a type of ApoB 100 cholesterol that is associated with coronary artery disease. However, the prevalence of ordering this test is low (<...
Abstract 4369005: Self Reported Importance of “Being Active” Associated with Better Physical Outcomes in Cardiac Rehab
Background: Improvement in physical function is related to improved survival for patients with cardiovascular disease and an important goal when undergoing cardiac rehabilitation (...
Abstract 4370462: Neuronal Degradation Biomarkers Are Associated with Neurocognitive Decline and Recovery After Cardiac Surgery
Background: Neurocognitive decline (NCD) is a well-documented complication associated with cardiac surgery. While several factors have been associated with NCD, there is no reliabl...
Abstract 4362068: Recurrent Hemopericardium Following Fibrinolytic Therapy: A Novel Case Requiring Emergency Surgery and Mechanical Circulatory Support
Background: Pericardial tamponade complicates fibrinolytic therapy in <1% of cases. However, recurrent hemopericardium post primary PCI that necessitates emergency cardiac surge...
Abstract 4372791: Lytics or Leave it? Prosthetic Valve Thrombosis with Severe Aortic Insufficiency
Description of case: A 39-year-old man with history of unicuspid aortic valve status-post bicuspidization (2017), subsequent severe aortic insufficiency prompting mechanical aortic...
Abstract 4367909: Distance as a Determinant: The Negative Impact of Rurality on Health Outcomes Among Adults with Congenital Heart Disease on Medicaid
Introduction: Access to specialized care is associated with improved health outcomes for adults with congenital heart disease (CHD). Accordingly, proximity to an ACHD-accredited me...
Abstract 4359847: RNA Binding Protein in Proliferative Cardiomyocytes: a Cross-species Meta-analysis from Mouse, Pig, and Human Transcriptomic Profiling Data
Background: In regenerative hearts, robust cardiomyocyte (CM) proliferation was observed in mice that underwent myocardial infarction on postnatal (P) day 1 (MI...
Abstract 4366322: Outcomes of Left Atrial Appendage Occlusion Among Cancer Patients with Atrial Fibrillation: A Meta-Analysis
Background: Atrial fibrillation (AF) is common among cancer patients and poses unique management challenges, especially regarding stroke prevention and bleeding risk. Left atrial a...
Abstract 4338161: Sqstm1/p62 Deficiency Remodels the Gut Microbiota Reducing Atherosclerosis and Improving Metabolic Outcomes in ApoE <sup>-/-</sup> Mice
Background: Atherosclerosis is a major cause of cardiovascular disease, and recent studies suggest the gut microbiome may modulate metabolic outcomes and vascular health. However,...
Abstract 4371091: Mental Disorders Associated with Increased Arrhythmia Burden During Acute Mental Stress In Individuals with Recent Myocardial Infarction.
Background: Acute stress has been linked to increased arrhythmic activity, but little is known about how mental disorders modify this relationship in patients with coronary heart d...
Abstract Sun803: Comparison of Manual Versus Mechanical Ventilation During Cardiopulmonary Resuscitation in Pediatric Swine
Introduction: Current pediatric cardiopulmonary resuscitation (CPR) guidelines recommend that a rescuer performs manual ventilation at a rate of 20-30 breaths per minute (bpm) with...
Abstract 4362905: Reduced occludin protein expression in aortic endothelial cells mediates the mechanism of endothelial barrier dysfunction in aortic dissection disease
Background: Aortic dissection (AD) remains a significant challenge in cardiovascular medicine. Previous studies have found that reduced endothelial cell tight junction ZO-1 protein...
Abstract 4359896: Interleukin-1 Blockade for Rheumatic Fever Pericarditis in a Steroid-Intolerant Patient: A Case Report
Introduction: In developed nations, acute rheumatic fever (ARF) is a rare cause of pancarditis, including pericarditis. Corticosteroids, though second-line agents for pericarditis,...
Abstract Sat307: Development and Validation of an Early Prediction Model for Brain Death Progression in Out-of-Hospital Cardiac Arrest Survivors Treated with Targeted Temperature Management: Implications for Organ Donation
Background: Out-of-hospital cardiac arrest (OHCA) survivors who regain spontaneous circulation may progress to brain death, but early prediction remains challenging. Accurate progn...
Abstract 4368211: Reversible Right Ventricular Dysfunction Secondary to Metastatic Diffuse Large B Cell Lymphoma
Presentation: A 78-year-old female with hypertension and chronic kidney disease was discharged from an outside hospital after a diagnostic and therapeutic pericardiocentesis with c...
Abstract 4366119: Factor V Leiden Does Not Increase In-Hospital Mortality Following Coronary Artery Bypass Grafting: A National Inpatient Sample Analysis
Background: Factor V Leiden (FVL) is a hereditary hypercoagulable state in which factor V is resistant to inactivation by activated protein C, causing activation of prothrombin and...