Angewandte Chemie International Edition
Articles in this Issue
Regiospecific 2,3‐Dialkylindole Synthesis Enabled by Alkylpalladium 1,2‐Migration to In Situ Formed Aldimine
Abstract2,3‐Dialkylindoles play crucial roles in natural products and pharmaceuticals, but the step‐efficient and regioselective construction of such privileged structures remains a long‐standing chal...
Temperature and Solvent Dual Switch Photochromic Chiral Ionic Hydrogen‐Bonded Organic Framework for Circularly Polarized Luminescence and Advanced Encryption
AbstractMulti‐response encryption materials with temperature control and time resolution have attracted widespread attention due to their unique response characteristics and higher application securit...
Controlling the Chirality of Metallo‐Cages by Manipulating the Stereochemistry of the Metal Centers
AbstractPrecise control over the chirality of metallo‐cages by manipulating the stereochemistry of metal centers is important in many practical applications, but is extremely challenging. In this stud...
Carbon and Oxygen Double Defects‐Enhanced Ru‐Based Catalyst for Ammonia Decomposition
AbstractAlthough ammonia is widely recognized as one of the most promising candidates for hydrogen storage and transformation, the catalytic mechanisms involved in ammonia decomposition remain insuffi...
Correction to “Copper(I) Catalysed Diboron(4) Reduction of Nitrous Oxide”
Enantioselective Photochemical Generation of a Short‐Lived, Twisted Cycloheptenone Isomer: Catalytic Formation, Detection, and Consecutive Chemistry
AbstractCyclohept‐2‐enone‐3‐carboxylic acid undergoes a photochemical isomerization from its cis‐ to its trans‐form either upon direct irradiation (λ = 366 nm) or in the presence of a triplet sensitiz...
Prebiotic Interconversion of Pyruvate and Lactate over Zeolite‐Supported Ni Catalyst
AbstractSubmarine hydrothermal vents harbor diverse microbial communities and have long intrigued researchers studying the origin of life. Transition metals in these environments can be reduced by ser...
Hydrogenation of “Readily Activated Molecule” for Glycine Electrosynthesis
AbstractThe hydrogenation of glyoxylate oxime is the energy‐intensive step in glycine electrosynthesis. To date, there has been a lack of rational guidance for catalyst design specific to this step, a...
Enhancing the Stability of Aqueous Membrane‐Free Flow Batteries: Insights into Interphase Processes
AbstractMembrane‐free flow batteries using immiscible electrolytes aim to overcome limitations of conventional redox flow batteries by eliminating expensive ion‐selective membranes. However, they face...
Routes to Pt Derivatives of High‐Valent Sulfur Oxofluorides S(═O)<sub>2</sub>F, S(═O)F<sub>2</sub>, and S(═O)F<sub>3</sub> by Fluorination and Oxygenation
AbstractMetal derivatives of high‐valent sulfur fluorides and oxofluorides can provid e fluorinated building blocks for materials science and bioactive compounds, but so far, such building blocks are...
Frustrated Lewis Pair (FLP)‐Like (Cyclo)Addition of Small Organic Molecules to a Stable Azomethine Ylide
AbstractAzomethine ylides are 1,3‐dipolar zwitterions typically used for constructing N‐heterocycles by 3+2‐cycloaddition reactions. We report here a pyridyl‐tethered isolable azomethine ylide (AY) th...
Electron‐Deficient Alkyne Lipids Enable Efficient Synthesis of Comparable Polymer Lipids via Copper‐Free Azide‐Alkyne Cycloaddition
Abstract Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug and gene delivery, providing colloidal stabilization and defining the biol...
Potassium Tetraiodatoiodate(III) Iodate(V): A Nonlinear Optical Crystal with Exceptional Second‐Harmonic Generation and Full‐Wavelength Phase Matching
AbstractThe development of nonlinear optical materials with large nonlinear optical susceptibilities, wide transmission ranges, and comprehensive full‐wavelength phase matching capabilities remains a...
Cooperative Supramolecular Polymerization in Both Polar and Non‐Polar Solvents via Heteroatom‐Driven Amphiphilicity
AbstractSupramolecular polymers in water and non‐polar solvents are extensively studied as model systems to mimic biological processes and as functional materials, respectively. The molecular designs...
Revealing Transition State Stabilization in Organocatalytic Ring‐Opening Polymerization Using Data Science
AbstractIn nature, enzymes leverage constituent amino acid residues to create catalytically active sites to effect high reactivity and selectivity. Multicomponent host–guest assemblies have been explo...
A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno‐ and Chemo‐Immunotherapy in Cisplatin‐Resistant Tumor Cells
AbstractDrug resistance is a significant challenge for tumor therapy. Activating immunity is an effective method to combat drug‐resistant tumors. Utilizing metallic chemotherapeutic agents to induce n...
Stereocontrolled Phenol‐Yne Click Polymerization Toward High‐Performance Bioplastics with Closed‐Loop Recyclability
AbstractHydroxyl‐yne click polymerization is a highly atom‐economic and powerful tool for constructing sequence‐controlled and structure‐diverse unsaturated polymers. However, the cis/trans stereochem...
Isolation of a Square Pyramidal Bis(amidophenolate)‐Supported As(III)‐Cation: Coordination‐Induced Electromerism at As
AbstractThe synthesis and structural characterization of a slightly distorted square pyramidal arsenium cation is reported. Spectroscopic, crystallographic, and computational evidence indicate that co...
Inside Back Cover: Hydrogen Binding Energy Is Insufficient for Describing Hydrogen Evolution on Single‐Atom Catalysts (Angew. Chem. Int. Ed. 23/2025)
High‐Fidelity In Vitro Packaging of Diverse Synthetic Cargo into Encapsulin Protein Cages
AbstractCargo‐filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can...
Engineering Heteronuclear Dual‐Metal Active Sites in Ordered Macroporous Architectures for Enhanced C<sub>2</sub>H<sub>4</sub> Production from CO<sub>2</sub> Photoreduction
AbstractPhotocatalytic C2H4 synthesis from CO2 and H2O by utilizing solar energy represents a promising sustainable process, yet its efficiency remains significantly limited. Herein, we proposed a dua...
Biomimetic Adhesion/Detachment Using Layered Polymers with Light‐Induced Rapid Shape Changes
AbstractGeckos achieve rapid and efficient adhesion and detachment on various surfaces within milliseconds due to the hierarchically structured fibrillar architecture of their toe pads. Extensive rese...
Perovskite Homojunction Solar Cells by Buried Interface Engineering
AbstractConstructing a strong p–n junction is an effective strategy to drive the separation of photogenerated charge carriers and boost the photovoltaic performance of solar cells. However, forming p‐...
Probing Inside the Catalyst Layer on Gas Diffusion Electrodes in Electrochemical Reduction of CO and CO<sub>2</sub>
AbstractGas diffusion electrodes (GDEs) are widely used in electrochemical CO and CO2 reduction reactions (CO(2)RR) in flow cells due to their ability to alleviate mass transport limitations of gaseou...