Angewandte Chemie International Edition
Articles in this Issue
Lower Critical Solution Temperature Active Supramolecular π‐Systems for Smart Applications
AbstractStimuli‐responsive supramolecular systems have emerged as an essential requirement for a wide range of smart applications in material sciences and biology. Among various responses, thermal res...
Engineering Covalent and Noncovalent Interface Synergy in MXenes for Ultralong‐life and Efficient Energy Storage
AbstractMXenes serve as pivotal candidates for pseudocapacitive energy storage owing to sound proton/electron‐transport capability and tunable topology. However, the metastable surface terminal proper...
Responsible Use of Kinematic Models: Correspondence on “Navigating Ball Mill Specifications for Theory‐to‐Practice Reproducibility in Mechanochemistry”
AbstractIn their recent article, Jafter et al. present “refined” kinematic models for planetary and mixer mills. While the improvement of such models is a valuable pursuit, we find that aspects of the...
LL‐37 and Its Truncated Fragments Modulate Amyloid‐β Dynamics, Aggregation and Toxicity Through Hetero‐Oligomer and Cluster Formation
AbstractLL‐37 and its variants with amphiphilic structure can modulate amyloid‐β (Aβ) fibril formation, but the detailed mechanism behind it is still unclear. By using four different peptides (LL‐37,...
Harnessing Electrocatalytic Coupling of Carbon Dioxide and Methanol for High‐Efficiency Formic Acid Production
AbstractThe coupling of electrocatalytic CO2 reduction (ECR) and methanol oxidation reaction (MOR) presents a promising strategy for simultaneous cogeneration of formic acid (FA) at both cathode and a...
A Metal‐Organic Polyhedron‐to‐Coordination Polymer Transition Revealed by 3D Electron Diffraction
AbstractPorous metal‐organic polyhedra (MOPs) have strong covalent and coordinate bonds that define the intrinsic pore of the cage. The intermolecular interactions between cages tend to be weaker, suc...
A Facile and Efficient Route to Achieve Polythiophene‐Based Nanoparticles With Various Morphologies
AbstractPolythiophene‐based nanoparticles (PTNPs), a prominent class of conjugated polymer nanoparticles (CPNs) with remarkable optical and electronic properties, have gained significant attention in...
Multifunctional Binding Interface Drives Near‐Unity CO Selectivity in Acidic CO<sub>2</sub> Electrolysis
AbstractThe electrocatalytic carbon dioxide (CO2) reduction is challenged by the parasitic hydrogen evolution reaction (HER) especially in acidic media. Here, we elaborate that redox‐active isoindigo,...
In‐Built Compatible Electrode‐Electrolyte Interphases for Quasi‐Solid‐State Li‐SPAN Batteries
AbstractLithium‐sulfur batteries have been regarded as a promising candidate for next‐generation energy storage systems owing to their high energy density and low cost. Sulfurized polyacrylonitrile (S...
In Situ Nanoscale Probing of Lithium‐Aluminum Alloying / De‐Alloying Kinetics and Mechanical Failure in All‐Solid‐State Batteries
AbstractAlloy anodes with high specific capacity are extensively utilized in all‐solid‐state batteries (ASSBs). However, they are challenged by interfacial kinetic and mechanical issues. Real‐time inv...
In Situ Exfoliation of Covalent Metal‐Organic Frameworks for Enhancing Photocatalytic Hydrogen Peroxide Production
AbstractTwo‐dimensional nanosheets exhibit largely enhanced photocatalytic activities for hydrogen peroxide (H2O2) production. Conventionally, the nanosheets are fabricated through ex situ approaches...
Host–Guest Metal Interaction in Cu‐In Single Atom Alloy Switching Electrocatalytic CO<sub>2</sub> Reduction Pathway
AbstractThe catalytic behavior of alloy electrocatalyst is strongly influenced by host–guest metal interaction, which governs adsorption energy and product selectivity. However, in conventional bimeta...
Energy Dissipation Mediated by Multiple Noncovalent Interactions in Hydrogen‐Bonded Organic Frameworks‐Based Hydrogels for Wearable Gesture‐to‐Recognition Translation
AbstractHydrogels hold great promises in intelligent wearable gesture‐to‐recognition translation devices, but high mechanical robustness usually encounters low sensitivity and poor cycling stability,...
Competitive Chirality Induction in Two‐dimensional Germanium Iodide Perovskites Enabling Highly Anisotropic Nonlinear Optical Response
AbstractChiral metal halide perovskites (CMHPs) are a promising class of chiroptical materials with significant potential applications in chiral‐optoelectronic and chiral‐spintronic devices. However,...
Mechanistic Insight into <i>Para</i> ‐Substituent Control of Thermal Half‐Lives in Arylazopyrazole Photoswitches
Abstract Arylazopyrazoles are versatile photoswitches with excellent photochromic properties and tunable thermal half‐lives, yet the mechanistic role of substitu...
A Solid‐State Crystallization Strategy for Direct Enzyme Encapsulation in Zr‐MOFs: Eliminating Harsh pH and Thermal Requirements of Liquid‐Phase Synthesis
AbstractConventional syntheses of robust Zr‐based metal‐organic frameworks (Zr‐MOFs) rely on harsh solvothermal conditions, precluding the inclusion of fragile functionalities such as enzymes or organ...
Inside Front Cover: A Solid‐State Crystallization Strategy for Direct Enzyme Encapsulation in Zr‐MOFs: Eliminating Harsh pH and Thermal Requirements of Liquid‐Phase Synthesis (Angew. Chem. Int. Ed. 43/2025)
Hydroalkylation of Unactivated Alkenes with Amides via Photoredox Catalysis and Triple Hydrogen Atom Transfer
AbstractRadical‐mediated hydroalkylation of alkenes offers a more direct and atom‐economical route to α‐alkylated carbonyl compounds, enabling the construction of various drug scaffolds, natural produ...
Casey M. Platnich
Mechanistic Divergence in Sulfur‐Ligated Iron(III)‐Alkylperoxo Reactivity: Aldehyde Oxidation Prevails over Deformylation
AbstractMetalloenzymes activate molecular oxygen within their catalytic cycles to generate a reactive species capable of substrate transformation. In many iron‐containing enzymes, it is a high‐valent...
Fluorine Modified Zeolitic Imidazolate Framework Enables Long‐Life Zn–I<sub>2</sub> Batteries by Suppression of Polyiodide Shuttle
AbstractAqueous zinc–iodine (Zn–I2) batteries have emerged as a promising candidate for large‐scale energy storage applications, owing to their inherent safety, cost‐effectiveness, and high specific c...
Regiodivergent Ligand‐Controlled Cobalt‐Catalyzed Reductive Hydroxymethylation of Alkynes with Aqueous Formaldehyde
AbstractAllylic alcohols are versatile and essential building blocks in synthetic chemistry, widely used for the preparation of complex molecules, pharmaceuticals, and materials. We report here a regi...
Bio‐Transport Regulation Inspired 5‐Fluorouracil Keto to Enol Tautomerism Achieving High Proton Conductivity
AbstractThe strategic modulation of proton transport kinetics and precise control of migration energy barriers in metal‐organic frameworks (MOFs) are essential for developing next‐generation proton co...
TASK2‐Inspired pH‐Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge
AbstractBiological ion channels can regulate finely the ion transmembrane permeation, with superhigh ion selectivity and on–off ion flux in response to external stimuli, for signal transduction and en...
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
AbstractSpatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor‐targeted therapy. Here, we introduce a Light‐Induced Tran...