Angewandte Chemie International Edition

Inside Front Cover: Light‐Driven Competitive Selection in a Protein‐Catalyzed Dissipative Peptide Replication (Angew. Chem. Int. Ed. 18/2026)

Unraveling Synthetase's Mode of Action: The Pyrrolysyl‐tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell

ABSTRACT Aminoacyl‐tRNA synthetases mediate the activation and transfer of amino acids to their cognate tRNA, which constitutes one of the initial events in protein biosynthesis. Eve...

Michał Ociepa

Unravelling the Intrinsic Reactivity and Colloidal Instability in Tin‐Based Halide Perovskite Precursor Solutions

ABSTRACT Narrow‐bandgap tin and mixed tin–lead halide perovskites are attracting growing interest for optoelectronic applications, yet the difficult‐to‐control crystallization proces...

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability

ABSTRACT We recently developed a high‐throughput directed evolution platform for engineering polymer degrading enzymes, and showcased its utility through the dev...

Correction to “Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition”

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

ABSTRACT Catalytic DNA molecules (DNAzymes) have garnered increasing attention as components of biosensing and diagnostic platforms due to their simplicity, prog...

Matrimid‐Derived Asymmetric Carbon Molecular Sieve Hollow Fibers With Engineered Ultramicropores for Precise Helium Separation

ABSTRACT Helium/methane (He/CH 4 ) separation is of strategic importance for energy and industrial applications, yet it r...

Ultrafast Ionic Cross‐Phase Transport in Nanofluidics for Simultaneously Boosting Osmotic Energy Conversion and Lithium Recovery

ABSTRACT The implementation of an integrated system adept at simultaneously harvesting energy and recovering resources from currently abandoned environments repr...

Pancake‐Like Surface Halide‐Fluorothiolate‐Enriched Au ₁₂ Ag ₃₀ Nanoclusters for Defect Passivation and Moisture Shielding in Perovskite Solar Cells

ABSTRACT There are few examples of the function‐oriented synthesis of atomically precise metal nanoclusters (NCs) whose ligand composition and geometry readily t...

Lighting up Ferroptosis Propagating via the Lung‐Heart Axis Exacerbates Cardiovascular Disease Through in Situ Imaging

ABSTRACT Cigarette smoke (CS)‐induced lung injury is a risk factor for atherosclerotic cardiovascular diseases (ASCVDs), with both diseases sharing a common path...

Electrochemical Dye Switching Assisted Spectral Demixing and 3D STORM Imaging

ABSTRACT Super‐resolution microscopy has advanced cellular imaging by enabling nanoscale resolution, while reliable multicolor strategies remain crucial for resolving multiple target...

Structure Tailoring Enabled Self‐Catalyzed Imidization for Engineering a Highly Adhesive and Ion‐Conductive Polyimide Network Toward Ultra‐Stable Silicon Anodes

ABSTRACT Silicon (Si) is widely recognized as one of the most promising anode materials for next‐generation lithium‐ion batteries (LIBs). Nevertheless, its pract...

cis‐Aziridines From Terminal Alkenes via Diastereoselective Intramolecular Electrocatalytic Hydroamination

ABSTRACT Aziridines are valuable building blocks with broad synthetic and biological relevance, yet general strategies for accessing 2,3‐disubstituted aziridines from stereochemicall...

Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry

ABSTRACT Polymer analysis tools form the backbone of modern polymer technology. However, traditional tools like size exclusion chromatography (SEC) fractionate based on hydrodynamic...

Photoinduced Cobalt Catalysis for Direct and Slow‐Release Homologation of Electron‐Deficient Alkenes Using Acetylene

ABSTRACT Homologation is of high value in organic synthesis, yet the two‐carbon extension of electron‐deficient alkenes remains challenging. Here we report a pho...

Outside Front Cover: DNA Flap‐Mediated Control of Transcription for Programmable RNA Synthesis (Angew. Chem. Int. Ed. 18/2026)

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

ABSTRACT We describe a photoenzymatic hydroalkylation reaction that enables the efficient and stereocontrolled synthesis of aryl glutarimide precursors—chemicall...

Bioinspired Design of F–Zn Sites in Layered Double Hydroxides for Photothermal Catalytic Upcycling of Polyethylene Terephthalate

ABSTRACT Chemical upcycling of plastic wastes into high‐value‐added products presents a promising pathway toward achieving a circular economy and mitigating environmental issues, yet...

High Spin Iron–Phosphinidene and Arsinidene Complexes With Attenuated Metal–Ligand Multiple Bond Character

ABSTRACT The MEH 2 salts (M = Na, K; E = P, As) react with high spin ( S = 2) PhB...

Organic Materials With Dual‐Morphology (Crystalline/Glassy) and High‐Temperature Phosphorescence Emission

ABSTRACT Organic room‐temperature phosphorescence (RTP) materials have attracted considerable attention due to their ultralong afterglow lifetimes and significant Stokes shift. Howev...

Photoconversion of Nitrogen to Ammonia by Peptidophotocatalyst

ABSTRACT Self‐assembling peptides are promising in the biomedical field; however, they are rarely used in the field of catalysis, let alone for catalytic nitroge...

MOFs as New Catalytic Platform for Covalent Adaptable Networks: Catalysis Meets Reinforcement

ABSTRACT Catalysis of bond exchange reactions is a versatile route to adjust kinetics and onset temperature of bond exchange reactions in covalent adaptable netw...

Structure‐Sensitivity Switch on Mo ₂ CT _x MXene: Steering CO ₂ Hydrogenation via Surface Termination and Copper Coordination

ABSTRACT The pursuit of precise product control in CO 2 hydrogenation represents a central challenge in catalysis, where...

Bio‐Photocatalytic Synergy Enables Valorization of CH ₄ and CO ₂ Into Hydrogen and 4‐Hydroxybenzoate in Engineered Methanotrophic Bacteria

ABSTRACT Valorization of decentralized one‐carbon chain (C 1 ) resources into value‐added products has garnered significa...