Angewandte Chemie International Edition
Articles in this Issue
Outside Back Cover: One Atom Makes a Big Difference in NHC‐Ligated Alloy Nanoclusters: From Structure and Properties to Catalysis (Angew. Chem. Int. Ed. 21/2026)
Inside Front Cover: Oxidative Damage Fine‐Tunes G‐Quadruplex Structures in Human Gene Promoters (Angew. Chem. Int. Ed. 21/2026)
Outside Front Cover: Lipid Modified with Pyridinium Betaine Manipulates Liposomal Membrane Fusion Behavior for Spatially Confined Cytoplasmic Delivery (Angew. Chem. Int. Ed. 21/2026)
Design of a Photoactuator Based on a Photosalient Crystal Driven by Solid‐State [2+2] Cycloaddition
ABSTRACT Soft microrobots have become an emerging branch of materials science owing to their capability to perform critical tasks in inaccessible, compact, confi...
Lipid Modified with Pyridinium Betaine Manipulates Liposomal Membrane Fusion Behavior for Spatially Confined Cytoplasmic Delivery
Abstract Spatially confining the membrane‐fusion effects of fusogenic delivery systems in tumors can enhance therapeutic efficacy and reduce systemic toxicity. H...
Oxidative Damage Fine‐Tunes G‐Quadruplex Structures in Human Gene Promoters
ABSTRACT Oxidative damage can convert guanine (G) into 8‐oxoguanine ( O8 G), resulting in altered gene expression and gen...
Triply‐Linked N‐Confused Porphyrin Dimers: Cross Conjugation‐Mediated Expansion of π‐Conjugation
ABSTRACT meso ‐ meso ′, α ‐ α...
A Robust Metal‐Organic Framework With ‘Molecular Gates’ for Efficient Separation of Ethane From Ethylene
ABSTRACT Ethane‐selective sorbents can enable single‐step purification of ethylene but remain elusive to date. We report a Zn‐based metal‐organic framework (...
Electrochemically Driven Enzymatic Oxidative Desymmetrization for the Enantioselective Construction of Silicon Stereocenter
ABSTRACT Chiral silicon‐stereogenic organosilanes are finding increasingly widespread applications in pharmaceutical science and biomedical materials. However, t...
Asymmetric Synthesis of NOSPIN Derivatives
ABSTRACT The spirobiindane scaffold represents one of the most important privileged structures for developing chiral catalysts and ligands. However, 7‐amino‐7′‐hydroxyl‐1,1′‐spirobii...
Ru Nanowires for Effective Low‐Temperature CO <sub>2</sub> Methanation in the Aqueous Phase
ABSTRACT The Sabatier reaction is a cornerstone for carbon‐neutral fuel synthesis, yet conventional catalytic systems face persistent challenges: hot‐spot‐driven...
Steric Hindrance and Secondary Interactions Govern Reconfiguration Between Two Complex Cu <sup>I</sup> Coordination Cages
ABSTRACT A tetramine subcomponent featuring 1,5‐naphthylene arms was designed to exhibit extensive secondary interactions when assembled around stereochemically...
A Pseudokinase Catalyzes Nitrile Formation in the Biosynthesis of a Potent Marine Toxin
ABSTRACT Several pseudokinases, previously regarded as dead enzymes due to the lack of catalytic residues, catalyze nucleotidylation. While they often utilize macromolecular substrat...