Circulation
Articles in this Issue
Abstract 4367864: Impella 5.5 Therapy as Bridge Therapy for Delayed Ventricular Septal Defect Repair
Introduction/Background: Ventricular Septal Defect (VSD) is a well-known and often fatal complication of myocardial infarction (MI), particularly when presentation is delayed. The...
Abstract 4347411: Successful Treatment of Severe Calcified Left Subclavian Artery Stenosis with Intravascular Lithotripsy Prior to Stenting: A Case Report
Subclavian artery stenosis is a rare but clinically significant cause of vertebrobasilar insufficiency and upper extremity ischemia. Management is challenging, especially in the presence of heavily ca...
Abstract 4371804: Restoring Function: Meta-Analysis of Functional and QoL Outcomes After PASCAL Mitral Valve Repair
Background: Traditional TEER studies have prioritized anatomical and technical success, often underreporting the outcomes that matter most to patients—functional status and health-...
Abstract 4341793: Oral PCSK9 Inhibitors for Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Trials
Introduction: Despite advances with injectable PCSK9 inhibitors, many patients with hypercholesterolemia remain unable to achieve LDL-C goals due to barriers such as cost, access,...
Abstract 4342377: Health at a Distance: Urban-Rural Disparities in Hypertensive Emergency
Introduction/background: Rural hospital closures and limited access to subspecialty care may adversely affect outcomes for patients with hypertensive emergencies—a growing cause of...
Abstract 4369857: The Impact of Transesophageal Echocardiography Operators on Left Atrial Exclusion During AtriClip Procedures
Introduction: Intraoperative transesophageal echocardiography (TEE) is essential to guide left atrial appendage (LAA) closure and exclusion. Despite a significant learning curve, T...
Abstract 4368035: Mapping Cardiogenic Shock Care in California: Geographic Gaps and Hospital Capability Across a Decentralized System
Background: Cardiogenic shock (CS) is a high-acuity condition with in-hospital mortality rates of 30–40%. Over time, the acuity and multimorbidity of patients with CS has increased...
Abstract 4368066: High Prevalence and Adverse Cardiovascular Outcomes of the Transthyretin p.Asp119Asn Variant in Japan
Background: Transthyretin tetramer destabilizing variants accelerate hereditary transthyretin amyloidosis and shorten survival. The contribution of transthyretin tetramer destabili...
Abstract 4368484: Patterns and Correlates of Heart Rate Among US Adults in the All of Us Research Program
Background: Heart rate is a core component of clinical assessment in patients with cardiovascular disease. However, single-point measurements of heart rate during clinical encounte...
Abstract 4363492: Self-reported History of Heart Attack among Patients with Type 1 versus Type 2 Myocardial Infarction
Background: The term “heart attack” is synonymous with myocardial infarction (MI). Epidemiologic studies that track MI incidence often rely on patient self-reported history of hear...
Abstract 4358635: Atrial Fibrillation in Genotyped Dilated Cardiomyopathy: Epidemiology and Associated Risk Factors - Insights from the SHaRe Consortium
Background: Atrial fibrillation (AF) is the most common arrhythmia in dilated cardiomyopathy (DCM) and is associated with adverse outcomes. Characterization of AF in DCM by genotyp...
Abstract 4370023: Are Discharge Barriers Responsible for Insurance-Based Differences in Length of Stay After Congenital Heart Surgery?
Introduction: Previous studies using national administrative data show that among patients who undergo congenital heart surgery, those with public insurance have longer length of s...
Abstract 4367684: The wandering stent: Tricuspid Valve Injury from a Migrated Endovascular Stent
Introduction: Endovascular stents are commonly used for vascular access in patients undergoing hemodialysis. While these devices are generally safe, rare but serious complications...
Abstract 4366967: The Impact of 20+ Years of Project ADAM in Preventing Mortality from Sudden Cardiac Arrest in Schools
Introduction: Project ADAM Ò (Automated Defibrillator’s in Adam’s Memory), was founded in 1999 after the sudden cardiac arrest of Adam Lemel...
Abstract 4368964: LncRNA Regulated by Triiodothyronine Confers Cardioprotection in High-Fat-Diet-Induced Atherosclerosis-Driven Myocardial Infarction
Hypothyroidism (HypoTH) is an independent and major risk factor for myocardial infarction (MI). However, long noncoding RNA (lncRNA; ncRNAs>200 bp) mechanisms in the cardiac thyroid hormone (TH) pa...
Abstract 4364607: Clinical Impact of Proton Beam Radiation on Pacemakers and ICDs: Insights from the RADIATE-CIED Registry
Background: Patients with cardiac implantable electronic devices (CIEDs) undergoing radiation therapy face potential risks of device malfunction. Proton beam therapy (PBT), with it...
Abstract 4369563: Expression of proteins encoded by putative atrial fibrillation risk genes in human left atrial appendage differs by AF state
Introduction: Atrial fibrillation (AF) is a common cardiac arrhythmia. Putative genes associated with AF risk have been identified through large genome wide association studies. Ho...
Abstract Sat1205: Etiology-Specific Outcomes in Out-of-Hospital Cardiac Arrest: Evaluating the Role of EMS Response Time Using National EMS Data
Background: Timely intervention is critical in out-of-hospital cardiac arrest (OHCA), but the influence of EMS time intervals may vary by etiology. This study examines how scene ti...
Abstract 4365172: Aortic Valve Type and Stenosis Can Be Identified from Wearable-Recorded Seismocardiograms Using Machine-Learned Classifiers
Introduction: Patients with aortic valve disease, such as bicuspid aortic valve (BAV), require regular echocardiography or cardiovascular (CV) MRI to monitor for complications such...
Abstract 4370225: Optimizing nursing team assessment with computer vision and machine learning: A feasible approach for interstage video analysis
Introduction: Despite decreases in mortality, infants with single-ventricle heart disease remain at significant risk for morbidity-associated “red flag” events during the interstag...
Abstract 4362357: Elevated Right Atrial to Pulmonary Capillary Wedge Pressure Ratio Within 1 Year From Unplanned Ventricular Tachycardia Ablation Predicts Periprocedural Acute Kidney Injury and Hemodynamic Instability
Background: Risk stratification for patients undergoing urgent ventricular tachycardia (VT) ablation remains limited, especially regarding right heart dysfunction. We investigated...
Abstract Sun206: Adipocyte-derived small extracellular vesicles and miR-29c-3p promoted apoptosis of cortical neurons in obese mice after resuscitation via downregulating neuronal MCL1
Background: Compared with normal weight patients, obese patients had a lower survival rate and worse neurological prognosis after cardiopulmonary resuscitation (CPR). Cortical neur...
Abstract 4369772: Association Between Estimated Glucose Disposal Rate and Risk of Stroke: A Systematic Review and Meta-Analysis
Background: Insulin resistance is central to metabolic dysfunction and a recognized risk factor for cardiovascular disease. Surrogate markers of insulin sensitivity, such as estima...
Abstract 4360114: Psychosocial and Socioeconomic Contexts Predict Expectations for Recovery following Cardiac Intensive Care Unit Stay
Background: Patients’ expectations for recovery after cardiac intensive care unit (CICU) hospitalization may influence their engagement in post-discharge care and overall recovery...
Abstract 4369711: Post-Impella Creatinine as a Predictor of Length of Stay Outcomes in Patients Undergoing Heart Transplant After Impella 5.5 Support
Background: Renal dysfunction is a known prognostic factor in advanced heart failure and among patients receiving temporary mechanical circulatory support (tMCS). However, the pred...