Circulation
Articles in this Issue
Abstract 4365204: <i> HP- <sup>13</sup> CMRAnalyst </i> : A MATLAB Application for Dynamic Cardiac Metabolic Imaging Analysis Using Hyperpolarized Carbon-13 MRI
Introduction: Hyperpolarized [1- 13 C] pyruvate magnetic resonance imaging (HP- 13 C MRI) enables re...
Abstract 4348378: Episodes of Higher Glucose Are Associated with Paroxysmal Atrial Fibrillation Occurrences During Continuous Glucose and Heart Rhythm Monitoring in Older Adults with Diabetes: the Atherosclerosis Risk in Communities (ARIC) Study
Background: Cardiac arrhythmias, particularly atrial fibrillation (AF), are highly prevalent in diabetes due, in part, to cardiac autonomic neuropathy. More frequent AF may contrib...
Abstract 4360016: Anatomical Stroke Topography Predicts Ventricular and Atrial Ectopic Burden
Introduction: Stroke-related autonomic dysregulation can trigger cardiac arrhythmias, but impact of stroke localization on ectopic burden is uncertain....
Abstract Sat402: Variability in Expert Confidence when Neuroprognosticating after Cardiac Arrest
Introduction: Neuroprognostication following cardiac arrest varies between centers and individual clinicians with inconsistent adherence to guideline-based strategies. Most in-hosp...
Abstract 4358425: VICTORION-INCEPTION: Consistent Low-density Lipoprotein Cholesterol Lowering With Inclisiran Following Acute Coronary Syndrome Independent of Index Lipid-lowering Therapy
Background: In the VICTORION-INCEPTION trial (NCT04873934), participants with recent acute coronary syndrome (ACS) randomized to receive inclisiran + usual care had greater low-den...
Abstract 4371736: Residual Learning Networks for Automated Detection of Hypertensive Retinopathy: A Multi-Institutional Validation Study
Introduction: Cardiovascular-retinal pathophysiology represents an emerging frontier in precision medicine, with hypertensive retinopathy (HR) serving as a critical biomarker for s...
Abstract 4365122: Conduction System Pacing: Short and Long-Term Clinical Outcomes in a Developing Country
Introduction: Conduction system pacing (CSP) is a more physiological pacing strategy with fewer deleterious effects compared to conventional myocardial pacing. However, data on out...
Abstract 4356291: Early renal denervation reduces ventricular arrhythmogenesis by improving Angiotensin II-disrupted expression of connexin 43 after acute myocardial infarction
Background: Renal denervation ( RDN ) has been widely studied to treat ventricular arrhythmias. Besides the neuronal and structural remodeli...
Abstract 4367113: Epicardium-directed mechanisms of cardiac repair in the infarcted murine heart
In the adult heart, the epicardium is activated following myocardial infarction (MI), contributing to cardiac repair primarily through the secretion of paracrine factors. However, the specific cellula...
Abstract 4345537: Development and Validation of a Simplified Martin/Hopkins Low-Density Lipoprotein Cholesterol Equation Using Machine Learning
Introduction/Background: The Martin-Hopkins equation is widely validated and used to estimate low-density lipoprotein cholesterol (LDL-C). However, some laboratories find implement...
Abstract 4364319: Patients Hospitalized for Acute Coronary Syndrome Can Self-Acquire an Electrocardiogram for Early Disease Detection and Response
Introduction/Background: Acute coronary syndrome (ACS) is potentially a life-threatening emergency, and prompt diagnosis and reperfusion are essential to prevent adverse outcomes....
Abstract Sat401: Quantitative Assessment of Blood-Brain Barrier Permeability Using Biotechnological Imaging Analysis for Contrast-enhanced Magnetic Resonance Imaging in Post-Resuscitation Care: A Non-invasive Surrogate Marker for Blood-Brain Barrier Permeability
Aim: This study investigated the relationship between quantitative assessments of gadolinium leakage in the cerebrospinal fluid (CSF) space, as seen on contrast-enhanced magnetic r...
Abstract 4373164: Surgical Outcomes After Delayed Diagnosis of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery: A Longitudinal Retrospective Study in a National Cardiovascular Center in Peru
Background: Anomalous origin of the left coronary artery from the pulmonary artery is a rare but potentially fatal congenital anomaly. Timely diagnosis and surgical repair are esse...
Abstract 4368490: Intra-Arterial Tenecteplase as an Adjunct to Endovascular Thrombectomy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Background: Intra-arterial thrombolytics have emerged as a potential adjunct to endovascular thrombectomy in patients with acute ischemic stroke, due to suboptimal functional outco...
Abstract 4369030: The National and Regional Impacts of Cold and Hot Ambient Temperature on Heart Failure Hospitalizations Among Older Adults in the United States
Introduction: Numerous studies have shown a U-shaped relationship between ambient temperature and cardiovascular mortality. However, few studies examined a temperature- heart failu...
Abstract 4359558: Underutilization of guideline-directed medical therapy following hospitalizations for heart failure with reduced ejection fraction among U.S. Veterans, 2022 to 2023
Background: Hospitalizations for heart failure with reduced ejection fraction (HFrEF) represent key opportunities to optimize guideline-directed medical therapy (GDMT). We sought t...
Abstract 4358910: Integrated Genomic Analysis Reveals Distinct Molecular Determinants of Human Fat Distribution
Background: Body fat distribution profoundly influences cardiometabolic risk, but the molecular drivers of regional fat accumulation remain incompletely defined. This study aimed t...
Abstract 4341783: Poor Glycemic Control is Associated with Increased Risk of Clinical Events in Older Diabetic Patients with Peripheral Artery Disease
Background: We recently found poor glycemic control (Hgb A1c >8%) to be strongly associated with increased risk of cardiovascular (CV) and limb events in diabetic patients with...
Abstract 4363704: YOSEMITE Rationale and Design: Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Zodasiran Efficacy and Safety in Adolescents and Adults with Homozygous Familial Hypercholesterolemia
Background/Synopsis: HoFH is a rare autosomal condition caused by mutations in the LDLR pathway resulting in impaired LDL-C clearance. Patients with HoFH have severe hypercholester...
Abstract 4361072: Impact of the 2017 ASCO Guidelines on Cardiac Surveillance Practices in Patients Receiving Anthracycline-Based Chemotherapy
Background: Transthoracic echocardiographic (TTE) surveillance for left ventricular dysfunction following cardiotoxic chemotherapy, particularly anthracyclines, is a key component...
Abstract 4372707: Coronary Calcium Density Parameters Improve Cardiovascular Risk Prediction beyond Agatston Score in Adults Aged 75 and Older: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Coronary artery calcium (CAC) is usually quantified by Agatston score, integrating both density and plaque area. Recently, calcium density is shown to be inversely asso...
Abstract 4362389: Triglyceride glucose index-BRI is better predicting cardiovascular disease incidence than TyG related indices: Findings from two nationwide prospective cohort study
Background: Elevated triglyceride-glucose (TyG) related indices, such as TyG-body mass index, TyG-waist-to-height ratio, TyG-waist circumference was associated with higher risk of...
Abstract 4367714: Bridge to Recovery: Successful Integration of Frozen Elephant Trunk and VA-ECMO in Acute Type A Dissection with Cardiogenic Shock
Introduction: Acute type A aortic dissection (ATAAD) is a life-threatening emergency requiring urgent surgical repair. The Frozen Elephant Trunk (FET) technique enables single-stag...
Abstract 4364741: Real-World Assessment of the Efficacy of Inclisiran in Lowering Low-Density Lipoprotein Cholesterol: Outcomes From AAH Tertiary Cardiovascular Clinics
Background: Inclisiran is a novel innovative therapy for the reduction of low-density lipoprotein cholesterol (LDL-C). However, real-world data about its efficacy are limited....
Abstract 4365309: The association of longitudinal NT-proBNP levels with echocardiographic measurements in heart failure with preserved ejection fraction: Insights from the PURSUIT-HFpEF Registry
Background: Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels during the stable phase are associated with poor prognosis in heart failure with preserved ejection...