Abstract 4363442: Old Tool, New Tricks: Elevated RCRI Scores Signal Higher Risk Following TAVR

P Pal Shah (University of Illinois Chicago, Chicago, Illinois, United States) S Savina Sahgal (University of Illinois Chicago, Plainfield, Illinois, United States) A Atreya Mishra (University of Illinois Chicago, Plainfield, Illinois, United States) A Andrew Carlson (University of Illinois Chicago, Chicago, Illinois, United States) S Siddharth Bhayani (University of Illinois Chicago, Chicago, Illinois, United States) S Suhas Seshadri (University of Illinois-Chicago, Chicago, Illinois, United States) R Raghav Matta (University of Illinois Chicago, Chicago, Illinois, United States) A Azmer Khan (University of Illinois Chicago, Chicago, Illinois, United States) R Rohan Bhattaram (University of Illinois Chicago, Chicago, Illinois, United States) R Runze Zhang (Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences) A Aanya Roy (University of Illinois Chicago, Chicago, Illinois, United States) B Bayan Hammad (University of Illinois Chicago, Chicago, Illinois, United States) A Arvind Draffen (University of Illinois Chicago, Chicago, Illinois, United States) Z Zachary Natsheh (University of Illinois Chicago, Chicago, Illinois, United States) D Daniel Tiu (University of Illinois Chicago, Plainfield, Illinois, United States) D David Tiu (University of Illinois Chicago, Plainfield, Illinois, United States) E Edward Salem (University of Illinois Chicago, Chicago , Illinois, United States) J Jesse Balami (University of Illinois Chicago, Chicago, Illinois, United States) N Nonye Uche (University of Illinois Chicago, Chicago, Illinois, United States) S Swetha Kalagara (University of Illinois Chicago, Chicago, Illinois, United States) N Neil Gupta (University of Illinois Chicago, Chicago , Illinois, United States) A Adriana Ene (University of Illinois Chicago, Chicago, Illinois, United States) A Aleyah Hattab (University of Illinois Chicago, Plainfield, Illinois, United States) A Aarushi Arora (University of Illinois Chicago, Chicago, Illinois, United States) H Humam Sufyaan (University of Illinois Chicago, Chicago, Illinois, United States) J Jennifer Dau (University of Illinois Chicago, Chicago, Illinois, United States) J Jonathan Silberstein (University of Illinois Chicago, Chicago, Illinois, United States) J Julia Yu (University of Illinois Chicago, Chicago, Illinois, United States) K Kayla Torres (University of Illinois Chicago, Chicago, Illinois, United States) L Laura Navarro (University of Illinois Chicago, Plainfield, Illinois, United States) M Manisha Singam (University of Illinois Chicago, Plainfield, Illinois, United States) M Mariam Ismail (Department of Chemistry, Hunter College) R Riya Rana (University of Illinois Chicago, Chicago, Illinois, United States) S Samer Habeel (University of Connecticut, Farmington, Connecticut, United States) S Simon Liu (University of Illinois Chicago, Chicago, Illinois, United States) S Srinidhi Chaganti (University of Illinois Chicago, Chicago, Illinois, United States) V Vidur Gurbuxani (University of Illinois Chicago, Chicago, Illinois, United States) S Stephanie Dwyer Kaluzna (University of Illinois Chicago, Chicago, Illinois, United States) V Vicki Groo (University of Illinois Chicago, Plainfield, Illinois, United States) A Adhir Shroff (University of Illinois Chicago, Plainfield, Illinois, United States)

Abstract

Introduction: The Revised Cardiac Risk Index (RCRI) is a validated tool used to predict the risk of adverse cardiac events in non-cardiac surgeries. It assigns one point for each of six risk factors: high-risk surgery, ischemic heart disease, heart failure, cerebrovascular disease, insulin-dependent diabetes, and serum creatinine >2.0 mg/dL. Scores are categorized as minimal (0), low (1), intermediate (2), and high risk (≥3), with greater scores correlating with greater risk of adverse events. The utility of RCRI in predicting risk for non-invasive cardiac procedures such as transcatheter aortic valve replacement (TAVR) has not been established. Hypothesis: We hypothesize that higher RCRI scores correlate with increased post-TAVR adverse events. Methods: We performed a retrospective cohort analysis of TAVR patients at an academic medical center (2018-2024). RCRI score was calculated using chart-abstracted comorbidities on a scale of 0-5 as TAVR was assessed as a low-risk procedure. Patients were then stratified into the four risk groups based on RCRI score. Mortality was the primary outcome. 30-day rehospitalizations, major adverse cardiac events (MACE), and post-procedural complications evaluated at 30 days, 6 months, and 12 months were secondary outcomes. Chi-squared tests and logistic regressions were used to assess associations across strata. Results: Of 298 patients, 18.1% were minimal risk, 34.9% low, 34.2% intermediate, and 12.8% high risk. Mortality was greater in high-risk (23.1%) compared to the minimal-risk patients (5.6%; p = 0.02). 30-day rehospitalizations were also more frequent in high-risk groups (p <0.001). There was a statistically significant increase in composite MACE (p = 0.005), cerebrovascular accidents (p = 0.0008), conduction abnormalities (p = 0.01), and heart failure exacerbations (p = 0.026) across strata at 6 months post-procedure. Each of these associations remained statistically significant at 12 months. There were no significant differences in race (p = 0.13) or gender (p = 0.20) across RCRI groups. Conclusions: While TAVR is generally well-tolerated, the RCRI may serve as a valuable tool for preprocedural risk stratification. It may aid in clinical decision-making and patient counseling, particularly when discussing the risks and benefits of the procedure with high-risk individuals, as well as provide opportunities for improved medical optimization prior to the procedure.

Article Details

Journal Circulation
Volume / Issue Vol. 152, Issue Suppl_3
Published November 04, 2025
ISSN 0009-7322
Publisher Lippincott Williams & Wilkins

Journal Info

Circulation

Lippincott Williams & Wilkins

ISSN: 0009-7322 Health Sciences

Authors (40)

P

Pal Shah

University of Illinois Chicago, Chicago, Illinois, United States

S

Savina Sahgal

University of Illinois Chicago, Plainfield, Illinois, United States

A

Atreya Mishra

University of Illinois Chicago, Plainfield, Illinois, United States

A

Andrew Carlson

University of Illinois Chicago, Chicago, Illinois, United States

S

Siddharth Bhayani

University of Illinois Chicago, Chicago, Illinois, United States

S

Suhas Seshadri

University of Illinois-Chicago, Chicago, Illinois, United States

R

Raghav Matta

University of Illinois Chicago, Chicago, Illinois, United States

A

Azmer Khan

University of Illinois Chicago, Chicago, Illinois, United States

R

Rohan Bhattaram

University of Illinois Chicago, Chicago, Illinois, United States

R

Runze Zhang

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

A

Aanya Roy

University of Illinois Chicago, Chicago, Illinois, United States

B

Bayan Hammad

University of Illinois Chicago, Chicago, Illinois, United States

A

Arvind Draffen

University of Illinois Chicago, Chicago, Illinois, United States

Z

Zachary Natsheh

University of Illinois Chicago, Chicago, Illinois, United States

D

Daniel Tiu

University of Illinois Chicago, Plainfield, Illinois, United States

D

David Tiu

University of Illinois Chicago, Plainfield, Illinois, United States

E

Edward Salem

University of Illinois Chicago, Chicago , Illinois, United States

J

Jesse Balami

University of Illinois Chicago, Chicago, Illinois, United States

N

Nonye Uche

University of Illinois Chicago, Chicago, Illinois, United States

S

Swetha Kalagara

University of Illinois Chicago, Chicago, Illinois, United States

N

Neil Gupta

University of Illinois Chicago, Chicago , Illinois, United States

A

Adriana Ene

University of Illinois Chicago, Chicago, Illinois, United States

A

Aleyah Hattab

University of Illinois Chicago, Plainfield, Illinois, United States

A

Aarushi Arora

University of Illinois Chicago, Chicago, Illinois, United States

H

Humam Sufyaan

University of Illinois Chicago, Chicago, Illinois, United States

J

Jennifer Dau

University of Illinois Chicago, Chicago, Illinois, United States

J

Jonathan Silberstein

University of Illinois Chicago, Chicago, Illinois, United States

J

Julia Yu

University of Illinois Chicago, Chicago, Illinois, United States

K

Kayla Torres

University of Illinois Chicago, Chicago, Illinois, United States

L

Laura Navarro

University of Illinois Chicago, Plainfield, Illinois, United States

M

Manisha Singam

University of Illinois Chicago, Plainfield, Illinois, United States

M

Mariam Ismail

Department of Chemistry, Hunter College

R

Riya Rana

University of Illinois Chicago, Chicago, Illinois, United States

S

Samer Habeel

University of Connecticut, Farmington, Connecticut, United States

S

Simon Liu

University of Illinois Chicago, Chicago, Illinois, United States

S

Srinidhi Chaganti

University of Illinois Chicago, Chicago, Illinois, United States

V

Vidur Gurbuxani

University of Illinois Chicago, Chicago, Illinois, United States

S

Stephanie Dwyer Kaluzna

University of Illinois Chicago, Chicago, Illinois, United States

V

Vicki Groo

University of Illinois Chicago, Plainfield, Illinois, United States

A

Adhir Shroff

University of Illinois Chicago, Plainfield, Illinois, United States