Circulation
Articles in this Issue
Abstract 4373500: Escalating Mortality from Amphetamine-Associated Heart Failure in the United States (2003–2022): A Nationwide Analysis of Regional and Demographic Disparities
Background: Heart failure (HF) remains a leading cause of morbidity and mortality in the U.S. Concurrently, amphetamine use disorder has emerged as an increasingly recognized contr...
Abstract 4371035: Myofibroblast Contractile Machinery is Essential for Cardiac Repair after Myocardial Infarction
Background: After myocardial infarction (MI), the injured myocardium is repopulated by cardiac fibroblasts (CFs), which rapidly differentiate into contractile cardiac myofibroblast...
Abstract 4370523: Atrial FDG Avidity is Associated with Atrial Volume Expansion
Background: Atrial myopathy includes structural remodeling processes that result in adverse cardiovascular conditions. Metabolic inflexibility, defined by altered substrate availab...
Abstract 4364617: Social Vulnerability, Cardiovascular Risk, and Sudden Death: Insights from the SUDDEN project
Social determinants of health are known to influence cardiovascular disease (CVD) risk. Communities experiencing greater social vulnerability often face structural disadvantages that contribute to hig...
Abstract 4361602: SGLT2 Inhibitors in LVAD Patients: A Multi-Center Propensity-Matched Cohort Analysis
Background: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are guideline-directed therapy for heart failure with reduced ejection fraction (HFrEF), yet their utility in patien...
Abstract 4369672: SENSE-FM: A SEmi-supervised Noise-agnostic Signal Encoder Foundation Model that Enables Label-Efficient Development of AI-ECG models for Wearables
Background: Artificial intelligence (AI) can diagnose a wide array of cardiac conditions from electrocardiograms (ECGs). Wearable and portable ECG devices may enable expanded AI-ba...
Abstract 4361985: The Hypertensive Heart: Mapping Global IHD Burden and Projections to 2050
Background: Hypertension is a key modifiable risk factor for ischemic heart disease (IHD), contributing significantly to global cardiovascular mortality. Understanding trends in IH...
Abstract 4363403: The Effect of Tirzepatide versus Semaglutide on Post-Operative Outcomes in Type 2 Diabetics Following Coronary Artery Bypass Grafting
Background: Post-operative cardiovascular outcomes after Coronary Artery Bypass Grafting (CABG) in patients with type 2 diabetes pose unique and significant clinical challenges. Al...
Abstract 4369308: AI-Driven Identification and Outreach for Familial Hypercholesterolemia: Early Results from the FIND-FH Initiative at a Single Academic Center
Introduction: Familial hypercholesterolemia (FH) is a genetic dyslipidemia characterized by increased low-density lipoprotein cholesterol (LDL-C) and greater risk for early atheros...
Abstract 4364013: Virtual Reality Curriculum Improves Pediatric Cardiology Fellow Understanding of Hypoplastic Left Heart Syndrome Palliation: A Multi-Center Study of the Michigan Anatomic Congenital Heart in 3D (MACH-3)
Background: Fellowship training in pediatric cardiology requires complex three-dimensional visuospatial reasoning. Previous work has shown that virtual reality (VR) curricula can i...
Abstract 4366959: Real-World Data Show No Preventive Effect of SGLT2 Inhibitors on Cardiac Dysfunction from Cancer Therapy in T2DM Patients
Background: Cancer therapy–related cardiac dysfunction (CTRCD) is a significant complication among cancer patients, particularly those with type 2 diabetes mellitus (T2DM). While r...
Abstract 4366222: Vagal Control and Cognitive Function among Patients with Heart Failure and Mild Cognitive Impairment
Significance: Individuals with heart failure (HF) have reduced vagal control, an indicator of autonomic nervous system function. Additionally, more than half of individuals with HF...
Abstract 4362146: Quantitative Myocardial Perfusion Assessment With Ultrafast Myocardial Contrast Echocardiography In Ischaemic Heart Disease – First in-human study
Background: Ultrafast ultrasound or High Frame Rate (HFR) myocardial contrast echocardiography (MCE) due to its high temporal resolution (>1000 frames/sec) can reduce noise and...
Abstract 4373229: Silent Threat: Cardiac Tamponade as a Rare Complication of Severe Hypothyroidism
Description of Case: A 53 year old female with past medical history of autoimmune thyroid disease post-thyroidectomy (not on levothyroxine for over one year), chronic lower extremi...
Abstract 4367417: A-band titin-truncating variant promotes the development of arrhythmia-induced cardiomyopathy in a novel genetically-engineered porcine model
Background: Titin truncating variants (TTNtv) are present in ~1% of the population and increase risk for cardiovascular complications like early onset atrial fibrillation (AF), dil...
Abstract 4359800: Acute Left Ventricular Thrombosis and Systemic Embolism Following Testosterone Therapy
Introduction: Testosterone replacement therapy (TRT) is linked to venous thromboembolism (VTE) and cardiovascular risks, but intracardiac thrombus formation has not been reported....
Abstract 4367671: Trends and Disparities in Cerebrovascular Disease-Related Mortality Among Individuals With Comorbid Metabolic Syndrome in the United States (2000-2019): A Nationwide Analysis
Background: Patients with metabolic syndrome (MetS) are at an increased risk of cerebrovascular disease. Given the limited data available, this study aims to explore contemporary c...
Abstract 4362995: Invasive Remapping to Assess Long-Term Durability of Pulmonary Vein Isolation for Pulsed Field Ablation with Zero Fluoroscopy Approach
Background: Pulsed field ablation (PFA) is a novel nonthermal ablation using irreversible electroporation to treat atrial fibrillation (AF). While PFA leads to rapid electrogram di...
Abstract 4367520: Safety of photon radiation therapy in patients with CIED – A real world experience
Introduction: The number of patients with cardiac implantable devices (CIED) who undergo radiation therapy (RT) is increasing. Previous studies have shown that the adverse effects...
Abstract 4364680: Characteristics associated with poor long-term outcomes in patients with Fontan palliation
Background: Although survival after Fontan palliation for single ventricle heart disease has improved, long-term Fontan circulatory failure (FCF) remains a significant clinical con...
Abstract 4361590: Atrial Fibrillation as a Causal Risk Factor for Dementia: Pooled Mendelian Randomization Analysis of 2.6 Million Individuals from Large-Scale Genome-wide Association Studies
Background: Atrial fibrillation (AF) has been linked to dementia in prior observational studies. Whether this reflects a causal relationship remains to be a topic for debate, as bo...
Abstract 4366595: Risk Stratification for Cancer Therapy-Related Cardiac Dysfunction: External Validation of a HER2+ Breast Cancer Nomogram
Background: Cancer therapy–related cardiac dysfunction (CTRCD) is a well-recognized adverse effect of HER2-targeted therapies, particularly trastuzumab. While current guidelines re...
Abstract 4357097: Metabolic but Not Hypertensive HFpEF Models Reflect Human Titin Modifications in Heart and Skeletal Muscle
Background: Reduced exercise tolerance in heart failure patients with preserved ejection fraction (HFpEF) is caused by elevated left ventricular filling pressures and peripheral sk...
Abstract 4350143: Hypoxia Conditioned Extracellular Vesicle Therapy Improves Cardiac Function in a Rat Model of Ischemic Cardiomyopathy
Introduction: Adipose-derived mesenchymal stem cells (AD-MSCs) cultured under hypoxic conditions are known to secrete extracellular vesicles (EVs) with protective effects against i...
Abstract 4368061: Long-term Cardiovascular Outcomes and Predictors of Sodium Glucose Cotransporter 2 Inhibitor in Takotsubo Cardiomyopathy: A Propensity Matched National Analysis of The Trinetx Database
Backround: Takotsubo cardiomyopathy (TTS) is a transient cardiac dysfunction often triggered by emotional or physical stress. While sodium-glucose cotransporter-2 (SGLT-2) inhibito...