Circulation
Articles in this Issue
Abstract 4373423: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)-Mediated Platelet Activation Elicits NETs Formation via Cathepsin-G
Introduction/Background: PCSK9 has been shown to induce neutrophil extracellular trap (NET) formation in experimental models, contributing to thrombotic processes. Heterozygous fam...
Abstract 4367796: Walking Impairment Questionnaire score declines after lower extremity revascularization are linked to adverse cardiovascular events and rivaroxaban dose not affect walking ability
Backgrounds: The Walking Impairment Questionnaire (WIQ) is a validated tool for assessing patient reported outcomes related to walking in patients with peripheral artery disease (P...
Abstract 4367751: Cardiovascular Outcomes of Oral Semaglutide in High Risk Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis
Background: Type 2 diabetes mellitus (T2DM) significantly increases the risk of cardiovascular events, particularly in high-risk patients—those with coexisting cardiovascular disea...
Abstract 4345573: Polygenic Risk Score and the Risk of Repeat Coronary Revascularization After Index Procedure: Findings from the UK Biobank
Background: Patients undergoing coronary revascularization (CR), including percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), are at increased risk...
Abstract 4371172: Artificial Intelligence-based screening for Hypertrophic Cardiomyopathy from Single-lead Electrocardiograms: A Multinational Development and Validation Study
Background: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden death in young and middle-aged adults and frequently goes undiagnosed due to the absence of accessible an...
Abstract 4363227: Reducing Carbohydrate Quantity Lowers 10-Year Predicted Risk of Cardiovascular Disease Using the PREVENT Equation: An Ancillary Study of the OMNICARB Trial
Background: Cardiovascular disease (CVD) remains a leading cause of death in the United States. While evidence suggests that lowering carbohydrate quantity may improve CVD risk fac...
Abstract 4368525: Feasibility of a Nurse Practitioner-led Interdisciplinary Virtual Clinic for Secondary Prevention in Stable Coronary Artery Disease
Background: Virtual care offers a promising alternative to in-person visits for management of coronary artery disease (CAD). The aim of this study is to evaluate the feasibility of...
Abstract 4364058: Polygenic Risk Scores Do Not Fully Explain Resilience to CVD in Individuals from Long Lived Families: UK Biobank
Background: Resilience to aging diseases is observed in families with a history of extreme longevity. They may be protected by 3 potential genetic mechanisms: 1) carrying a lower d...
Abstract 4362299: Vascular Smooth Muscle Cell-Specific Guanylyl Cyclase-A/Natriuretic Peptide Receptor-A Gene is Required for Regulation of Blood Pressure and Vasorelaxation
Introduction: Atrial and brain natriuretic peptides (ANP and BNP) bind to natriuretic peptide receptor-A (NPRA), generate the second messenger cGMP, and lower blood pressure (BP)....
Abstract 4352828: Elimination of Ventricular Tachycardia and Premature Ventricular Complexes Following Surgical Excision of Left Ventricular False Tendon
Description of Case: This is a 17 year old male referred for frequent premature ventricular contractions (PVCs) and numerous salvos of non-sustained monomorphic ventricular tachyca...
Abstract 4365618: Angio-IMR - A Novel Angiography-Derived Index of Microcirculatory Resistance for Assessment of Coronary Microvascular Dysfunction
Background: Approximately 50% of patients with angina who undergo invasive coronary angiography (ICA) do not exhibit obstructive epicardial coronary artery disease. A significant s...
Abstract 4359164: A Focus for Improvement - Factors for Lab Adherence in a Pediatric Preventive Cardiology Program
Introduction/Background: While many symptoms of cardiovascular disease do not manifest until adulthood, the origins of increased cardiovascular risk can begin during childhood. Chi...
Abstract 4364799: Macrophage senescence is associated with expansion of atherosclerotic plaque’s lipid/necrotic core: implications in plaque destabilization
Background: The hallmark of high-risk atheroma is presence of a large lipid/necrotic core (LNC) containing macrophages (MF), foam cells and necrotic tissue. Enlargement of the core...
Abstract 4371485: One-Year Outcomes of Bisoprolol vs Metoprolol Succinate in Patients with Heart failure with reduced ejection fraction and End Stage Kidney Disease: A Propensity-Matched Study
Background: Patients with heart failure with reduced ejection fraction (HFrEF) and end-stage renal disease (ESRD) represent a high-risk population in whom optimal beta-blocker sele...
Abstract 4360828: Vitamin D Deficiency Is Associated With Increased Risk of Atrial Fibrillation in Black Women
Background: Significant racial disparities exist in the prevalence of both vitamin D deficiency and atrial fibrillation (AF). Blacks demonstrate lower AF rates despite higher vitam...
Abstract 4362838: Dynamic Left Ventricular Outflow Tract Obstruction in a Patient Post Transcatheter Aortic Valve Replacement Induced by Left Bundle Branch Area Pacing Following Atrioventricular Junction Ablation
Description of Case: An 81-year old-female with paroxysmal atrial fibrillation (AF) and severe aortic stenosis presented with AF with rapid ventricular response and volume overload...
Abstract 4357265: Mobile Phone Auscultation Using Non-linear Dynamics Analysis to Detect Aortic Stenosis
Introduction: Aortic stenosis (AS) is the most prevalent valvular disorder in the United States with a lengthy presymptomatic period and variable course. Patients with symptomatic...
Abstract 4359116: Genome Wide Association Study Identifies Loci Associated with Pulmonary Pressure
Background: Rare Mendelian drivers of pulmonary arterial hypertension (PAH) have been identified, but the contributions of common genetic variation to pulmonary pressure in other c...
Abstract 4370534: Guideline-Directed Medical Therapy Prescribing Trends in Patients with Heart Failure with Preserved Ejection Fraction: A Nationwide Analysis
Introduction: HFpEF remains under-recognized, and management strategies can often be confused with those of HFrEF. While SGLT2i, MRAs, GLP-1 RAs, are now standard of care, and angi...
Abstract 4371834: Targeting Cerebrovascular Risk in Diabetes: GLP-1 Receptor Agonists as Neuroprotective Agents
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established therapies for type 2 diabetes (T2D) that lower major adverse cardiovascular events. Their specific...
Abstract 4345580: Cardiac projecting NPY2r expressing neurons in stellate ganglia remodel myocardium in cardiac injury-related settings
Introduction: Sympathetic regulatory aspects of cardiac functions are imbedded in the neural circuits of postganglionic sympathetic neurons residing in the stellate ganglia. Postga...
Retracted: Abstract 4350116: β <sub>1</sub> -adrenergic autoantibodies (β <sub>1</sub> -AA) augment macropinocytosis in CD4 <sup>+</sup> T cells, leading to the expansion of CD4 <sup>+</sup> CD28 <sup>−</sup> T cell subsets in heart failure.
Background: β 1 -adrenergic autoantibodies (β 1 -AA), pathogenic autoantibodies targeting β...
Abstract 4362796: Comparison of the association of vascular aging constructed by different indices with the risk of cardiovascular events
Introduction: Vascular aging (VA) refers to the progressive deterioration of vascular structure and function with age. Vascular age exceeding chronological age indicates higher car...
Abstract 4362449: In Vitro Disease Model-based Investigation of Endothelial Cell Behaviour Relevant to Pulmonary Arteriovenous Malformations Development After the Glenn Procedure
Introduction: Pulmonary arteriovenous malformations (PAVM) development severely limits the long-term durability of the corrective surgical treatment and survival for univentricular...
Abstract 4367120: Impact of Aortic Valve Calcification on Functional Valve Area and Cardiac Structure and Function in a Phase 2 Trial of Ataciguat
Background: Calcific aortic valve stenosis (CAVS) is characterized by the progressive accrual of aortic valvular calcium (AVC), resulting in impaired valvular compliance and mechan...