Circulation
Articles in this Issue
Abstract 4362948: Use of a Principled Framework to Compare Cardiovascular Outcomes from the FOURIER Trial to a FOURIER like-External Control Arm Using Real-World Data
Background: In open-label extension studies, concurrent control arms are not always feasible. Further Cardiovascular Outcomes Research with PCSK9 Inhibition in subjects with Elevat...
Abstract 4343925: The Inflammasome and Fibroblast Activation Protein in Heart Failure with Reduced Ejection Fraction
Background: An important cause of HF is that of left ventricular (LV) pump failure, termed HF with reduced ejection fraction (HFrEF), and is primarily caused by ischemic heart dise...
Abstract 4366962: Updated Meta-Analysis of Randomized Controlled Trials Evaluating the Safety and Efficacy of Inclisiran in Hyperlipidemia
Background: Inclisiran, a small interfering RNA (siRNA), inhibits hepatic PCSK9 synthesis, leading to significant LDL-C reduction. Previous meta-analyses have addressed short-term...
Abstract 4362756: Sodium-Glucose Cotransporter-2 Inhibitors in Moderate Aortic Stenosis
Introduction: Moderate AS is associated with an increased risk of both CV and all-cause mortality. There are currently no approved medications to slow its progression to severe AS....
Abstract 4373688: Association Between Regular Yoga Practice and Reduced Incidence of Acute Coronary Syndrome in Hypertensive Adults
Background: Yoga is associated with improved cardiovascular risk factors, but its impact on major adverse cardiac events remains uncertain. We evaluated whether regular yoga practi...
Abstract 4349545: Shifting Trends in Type 1 and Type 2 Myocardial Infarction Diagnoses and Mortality: A National Inpatient Sample Analysis
Background: The 2018 Fourth Universal Definition of Myocardial Infarction reclassified it into five subtypes, including type 1 myocardial infarction (T1MI), due to acute atherothro...
Abstract 4363075: Fluoropyrimidine-Induced Angina: Clinical Characteristics, Management Strategies, and Outcomes at a Quaternary Referral Center
Background: Cardiovascular toxicity is a common complication of fluoropyrimidine therapy, with angina from coronary vasospasm being the most frequent adverse effect. Despite its pr...
Abstract 4363475: Murmur Screening Patterns Among High School Athletes
Background: While murmurs in youth are commonly benign, some may represent underlying pathology associated with an increased risk of sudden cardiac death. This study aims to charac...
Abstract 4360857: Changes in Lipoprotein(a) and Oxidized Phospholipids Are Associated with Myocardial Inflammation but Not Systemic Inflammatory Markers Following an Acute Myocardial Infarction
Background: Lipoprotein(a) [Lp(a)] is a major carrier of the pro-inflammatory oxidized phospholipids on apo-B containing lipoproteins (OxPL-apoB). In the OCEAN(a) DOSE trial olpasi...
Abstract 4371070: Mechanistic Insight into Disturbed Flow–Induced Mitochondrial Copper Overload and Cuproptosis in Atherosclerosis
Background: Disturbed flow (D-flow), a pro-atherogenic hemodynamic force, promotes endothelial cell (EC) dysfunction and atherosclerosis through poorly understood mechanisms. Coppe...
Abstract 4369532: Estimated absolute coronary heart disease risk reduction with Lp(a) lowering among adults with atherosclerotic cardiovascular disease
Background: Elevated lipoprotein(a) [Lp(a)] is a presumed causal risk factor for coronary heart disease (CHD). Estimating the absolute CHD risk reduction with potential Lp(a) lower...
Abstract 4369533: Loss of Polycystin-1 Enhances Cardiomyocyte Beta-Adrenergic Signaling
Introduction: Cardiovascular disease is the leading cause of death among individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD). While these conditions are often att...
Abstract 4362968: Coronary atherosclerotic plaque classification in hypercholesteremic pigs: new tool for drug discovery and testing anti-atherogenic therapies
Background: Animal models facilitate study of coronary atherosclerotic disease. Currently, there is no formalclassification of coronary plaques in the animal models. Pigs are the F...
Abstract Or125: Ventilation Monitoring in Out-of-Hospital Emergency Care
Introduction: We evaluated delivery of the American Heart Association (AHA) ventilation guidelines by emergency medical services (EMS) providers delivering cardiac arrest care usin...
Abstract 4341860: Machine Learning Model Outperforms Conventional Score to Distinguish Transthyretin Amyloid Cardiomyopathy from Other Cardiac Conditions that Cause Left Ventricular Hypertrophy
Introduction: Early and accurate diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) is known to improve prognosis. However, it is sometimes challenging to distinguish ATTR...
Abstract 4371394: Improved Quality of Life Following Cardiologist-Directed Care in Postural Orthostatic Tachycardia Syndrome
Introduction: Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic autonomic disorder mainly found in a younger female demographic and is characterized by orthostatic into...
Abstract 4364087: Impact of Social Isolation and Loneliness on All-Cause and Cardiovascular Mortality in Individuals with Pre-existing Cardiovascular Disease: A UK Biobank Cohort Study
Social isolation (9.2%-14.4% prevalence) and loneliness (~25% prevalence) are global public health concerns. This prospective cohort study quantifies their impact on all-cause and cardiovascular morta...
Abstract 4359390: Low-Dose Semaglutide Attenuates Coronary Artery Pathology and Improves Vascular Function Independent of Weight Loss in a Porcine Model of Cardiometabolic HFpEF
Background: Coronary microvascular dysfunction is a common finding in HFpEF and contributes to diastolic dysfunction, fibrosis, and exercise intolerance. Semaglutide, a GLP-1 recep...
Abstract 4343962: A Shocking Postpartum Course
Description of Case: A 34-year-old female G3P3 presented at 6 weeks postpartum with acute chest pain, dizziness, and bradycardia. Troponin in ED was 79, then 873 at 2-hours and 3,6...
Abstract 4373295: Closing the Gap: Improved Survival with Early Catheter Ablation in Sustained VT – A Multicenter Real-World Study
Background: Catheter ablation is guideline-recommended for sustained ventricular tachycardia (VT) in patients with structural heart disease, yet real-world utilization and effectiv...
Abstract 4346626: A Therapeutic Vaccine Against Transforming Growth Factor-β Prevents Aortic Aneurysm Formation in a Mouse Model of Marfan Syndrome
Background: Marfan syndrome (MFS) is a heritable autosomal dominant multisystem disorder of connective tissues caused by variants in FBN1 ge...
Abstract 4369572: Multi-Population Genome-Wide Association Study of Bicuspid Aortic Valve
Background: Bicuspid aortic valve (BAV) is a common congenital heart defect associated with serious cardiovascular complications, including thoracic aortic aneurysm and dissection...
Abstract 4364300: The Senolytic Navitoclax (ABT263) Reduces Coronary Atherosclerosis and Upregulates Plaque Stability in Atherosclerotic Pigs
Background: Cell senescence is an irreversible cell proliferation arrest associated with aging, tumorigenesis, and atherogenesis. The senolytic Navitoclax (ABT263) is an FDA-approv...
Abstract 4372825: A Novel Cardioprotective Mechanism in Myocardial Reperfusion Injury: Dual Neutrophil Modulation and ROS/HOCl Scavenging by an Atypical Chemokine
Background: Myocardial ischemia-reperfusion (IR) injury exacerbates cardiomyocyte death following acute myocardial infarction. Macrophage migration inhibitory factor (MIF) is a red...
Abstract 4367847: Predictors of Mechanical Circulatory Support Utilization Across Racial and Ethnic Groups in Heart Failure–Related Cardiogenic Shock: A National Perspective
Background: Mechanical circulatory support (MCS) is pivotal in treating heart-failure–related cardiogenic shock (HF-CS), yet real-world deployment may hinge on social and instituti...