Circulation
Articles in this Issue
Abstract 4370080: Detection of indication-relevant and incidental arrhythmias on ambulatory ECG recordings by artificial intelligence compared to ECG technicians
Background: In the DRAI MARTINI study, the DeepRhythmAI (DRAI) algorithm had a superior sensitivity for arrhythmia detection compared to ECG technicians. However, it has not been r...
Abstract 4370119: Polycythemia Vera as an Underrecognized Cause of Aortic Dissection in a Patient Without Traditional Cardiovascular Risk Factors
Aortic dissection is a life-threatening condition most commonly associated with chronic hypertension, connective tissue disorders, and atherosclerosis. Polycythemia vera (PV), a chronic myeloprolifera...
Abstract 4371436: Prognostic Value of Low Aortic Forward Flow Assessed by CMR in Moderate to Severe Aortic Stenosis
Background: A low-flow state is associated with worse outcomes in aortic stenosis (AS). Doppler-derived stroke volume accuracy could be limited by geometric assumptions and measure...
Abstract 4369343: Adults with Arrhythmias and Cardiomyopathy Have Lower WHO-QOL Health Satisfaction and Different Wellness Intervention Preferences
Background: People living with chronic heart conditions often experience poor quality of life (QoL) and reduced well-being; however, the intervention preferences to promote well-be...
Abstract 4365633: The 5,000+ Plasma Proteome of an Atherosclerosis Mouse Model Identifies Known and Potential Disease Drivers
Background: Mutations in the LDL receptor (LDLR) are causal for familial hypercholesterolemia, inciting the Ldlr-/- model for atherosclerosi...
Abstract 4373171: Progressive Diastolic Dysfunction Detected by Cardiac MRI in Adults with a Systemic Right Ventricle
Background: Systemic right ventricular (RV) dysfunction is a major clinical concern in adults with d-transposition of the great arteries (d-TGA) after atrial switch and those with...
Abstract 4365852: LDL Associates with Decreasing NKp46 Expression on NK cells as a Potential Contributor to Increased Cardiovascular Disease Risk
Background: Dyslipidemia disproportionately affects African American (AA) women and contributes to disparate cardiovascular disease (CVD) outcomes. We previously showed that Natura...
Abstract 4373456: Beyond the Biopsy: Serial Cardiac MRI Reveals Diagnostic and Prognostic Value in Postpartum Eosinophilic Myocarditis
Description of Case: A 37-year-old woman with hypertension, polycystic ovarian syndrome, and a family history of eosinophilic esophagitis presented 8 weeks postpartum with progress...
Abstract 4373553: Differences in Social Determinants of Health And Health Literacy Between Individuals With Sickle Cell Disease With and Without a History of Stroke
Introduction: Sickle cell disease (SCD) affects approximately 100,000 individuals in the United States. One of the common complications of SCD is stroke, affecting up to 24% of the...
Abstract 4359916: Sex and Age Influence Surgical Aortic Valve Prosthesis Type in Very Young Adults
Background: Aortic valve prosthesis selection is complex for very young adults. We aimed to determine whether type of aortic valve prosthesis (mechanical vs. bioprosthetic vs. Ross...
Abstract 4365282: Predicting Aortic Diameter Expansion in Acute Uncomplicated Type B Aortic Dissection Using a Novel Voxel-Based Statistical Shape Modeling Approach
Background: Type B aortic dissection (TBAD) occurs when a tear develops in the intimal layer of the descending aorta. Aortic expansion remains a major factor limiting acuate uncomp...
Abstract 4362007: Sex-Specific Prognostic Implications of Coronary Physiology and Microvascular Dysfunction
Background: Sex differences in coronary physiology have been reported, particularly with regard to higher resting coronary flow in women. Resting flow is independently associated w...
Abstract 4366401: Artificial Intelligence-Based Coronary Artery Calcium (AI-CAC) Score Empowers the “Power of Zero”: An AI-CVD Study within the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: The “Power of Zero” refers to the excellent negative predictive power of a coronary artery calcium (CAC) score of zero. Because CAC is currently reported using the Agat...
Abstract 4357689: Upfront Combination of High-Intensity Statin and Ezetimibe Reduces Major Adverse Cardiovascular Events in Acute Myocardial Infarction: A Target-Trial Emulation
Background: High-intensity statin treatment has well-established benefits in patients following acute myocardial infarction (AMI). However, the efficacy of combination therapy with...
Abstract 4361945: Arrhythmias as Early Predictors of CKD: Real-World Evidence from a National Cardio-Kidney-Metabolic Cohort
Background: While CKD is a known risk factor for arrhythmias, the reverse association, arrhythmias preceding CKD, is also recognized. Emerging evidence highlights a bidirectional r...
Abstract 4370015: Associations of baseline and longitudinal changes in MASLD with risk of heart failure events in type 2 diabetes and overweight or obesity: the Look Action for Health in Diabetes (Look AHEAD) Trial Liver Ancillary Study
Introduction: Adults with type 2 diabetes (T2D) and overweight or obesity have a high prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is assoc...
Abstract 4335818: MST1 Promotes the Development of Aortic Aneurysm and Dissection by Inhibiting FLNB-RAC1 Activity
Background: Aortic aneurysm and dissection (AAD) are life threatening cardiovascular emergencies while the pathogenesis mechanism remains unclear. Mammalian sterile 20-like kinase...
Abstract Sun304: Impact of Advanced Cardiac Life Support Medications on Discharge Neurologic Function for Survivors of Cardiac Arrest With ECPR
Introduction: Several medications used during cardiac arrest have been associated with poor neurological outcomes. As most patients who sustain cardiac arrest die, the effect of AC...
Abstract 4366989: Pathogenic variants in myoferlin ( <i>MYOF)</i> cause arrhythmogenic cardiomyopathy
Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited disease characterized by fibrofatty ventricular remodeling and arrhythmias. ACM patients are at risk for sudden card...
Abstract 4371407: Integrated Multi-Omics Analysis Reveals Distinct Genetic Architectures Driving HFpEF Subphenotypes
Background: Heart Failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with complex pathophysiology, limiting discovery in traditional genome-wide associati...
Abstract 4360927: Flow Matters: Prognostic Value of Sex-Specific Transvalvular Flow Rate in PLFLG Aortic Stenosis
Background: Paradoxical low-flow, low-gradient (PLFLG) severe aortic stenosis (AS) is a high-risk phenotype characterized by low transvalvular gradients despite preserved left vent...
Abstract 4366575: Performance Benchmarking of Smaller Language Models Against GPT-4 for Predicting Reasons for Oral Anticoagulation Nonprescription in Atrial Fibrillation
Background: Oral anticoagulation (OAC) reduces stroke risk in atrial fibrillation (AF), yet nonprescription rates approach 50% with poorly characterized reasons. Proprietary large...
Abstract 4369790: AI-Driven Electrocardiographic Risk Stratification for Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis
Background: Hypertrophic cardiomyopathy (HCM) is a common cause of sudden cardiac death (SCD) in young people, sometimes accompanied by malignant ventricular arrhythmias. Recent ad...
Abstract 4365817: Engineering Of An All-iPSC Model Of Vascularized Cardiac Tissue
Modeling cardiac disease has been a central goal in tissue engineering. Engineered human cardiac tissues now serve as valuable platforms for studying heart tissue replacement, disease modeling, and ad...
Abstract 4361453: Inaccurate information regarding cardiovascular disease prevention enabled by generative artificial intelligence
Background: Inaccurate information regarding cardiovascular disease (CVD) prevention is present on the internet and may influence medical decisions. Artificial intelligence “bots”...