Circulation
Articles in this Issue
Abstract 4347065: ROS Scavenging Attenuates Parasympathetic Nerve Activity and Overlying Complex Fractionated Atrial Electrograms (CFAEs) in Persistent Atrial Fibrillation—New Mechanistic Insights in Atrial Fibrillation
Background: Reactive oxygen species (ROS), complex fractionated atrial electrograms (CFAEs), and the autonomic nervous system play an important role in atrial fibrillation (AF). Ho...
Abstract 4350904: Comprehensive Plasma Transcriptomics Profiling Identifies a Small Set of Circulating MicroRNA Biomarkers to Distinguish Hypertrophic Cardiomyopathy from Other Cardiomyopathies with Left Ventricular Hypertrophy
Introduction: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. It can be challenging to distinguish HCM from other cardiomyopathies with left ventricul...
Abstract 4368311: Prepregnancy Cardiovascular Health Score and Hypertensive Disorders of Pregnancy
Introduction: Hypertensive disorders of pregnancy (HDP, i.e. preeclampsia, gestational hypertension, eclampsia or HELLP syndrome) are common. Cardiovascular health (CVH) is promote...
Abstract 4357557: Renal Denervation versus Baroreflex Activation Therapy in Resistant Hypertension: Outcomes from a Real-World Registry
Background: Device-based therapies for hypertension, including renal denervation and baroreflex activation therapy, offer alternative strategies for blood-pressure control....
Abstract 4347461: Association Between Site and Operator Procedural Volume and Perioperative Outcomes Following Peripheral Vascular Interventions for Chronic Limb-Threatening Ischemia
Background: Peripheral vascular intervention (PVI) is used to promote limb preservation in chronic limb-threatening ischemia (CLTI). Despite advancements in medical technology and...
Abstract 4345173: Triventricular Pacing Is Associated with Improved Functional Capacity Compared to Biventricular Pacing in Heart Failure Patients: A systematic Review and Meta-Analysis
Introduction: Cardiac resynchronization therapy (CRT) is an established intervention for heart failure (HF) patients with intraventricular conduction delays. Triventricular pacing...
Abstract 4365899: Trends in Myocarditis Incidence and Mortality in South Asia and the United States, 1990–2021
Background: Myocarditis remains an underrecognized contributor to cardiac morbidity and mortality globally. There is limited understanding of how myocarditis trends have evolved ov...
Abstract 4362942: Aligned nanofiber cardiac patch enhances structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) possess significant therapeutic potential for myocardial regeneration. However, clinical application remains constrained due to t...
Abstract 4369844: Evaluating Real-World Use of Artificial Intelligence-Augmented Pre-Procedure Phone Calls for Cardiac Catheterization
Background: Burnout and staffing shortages remain a critical concern, particularly among registered nurses (RNs) involved in repetitive administrative workflows. Pre-procedure call...
Abstract 4343077: Combination of Prolonged Water Fasting and Tirzepatide for Treatment of Refractory Morbid Obesity: Case Report
Background: Water fasting, defined as the complete abstinence from caloric intake, has been shown to be safe for up to 21 days with benefits including weight loss, improved blood p...
Abstract 4370153: Late gadolinium enhanced cardiac magnetic resonance imaging scar is associated with a delayed effectiveness of radiofrequency ablation of premature ventricular contractions.
Background: Radiofrequency ablation (RFA) is an effective treatment of premature ventricular contractions (PVC). Patients with an initially unsuccessful ablation may demonstrate la...
Abstract 4367982: Unmasking an Inferior Sinus Venosus Defect Following Mitral Valve Surgery: A Rare Cause of Postoperative Hypoxemia
Case Presentation: A 67-year-old woman with history of remote surgical atrial septal defect (ASD) repair in childhood and severe mitral regurgitation presented for surgical mitral...
Abstract 4364229: AngioVac-Assisted Thrombectomy of Intracardiac Thrombi in a Patient with Adult-Onset Still’s Disease, Pulmonary Hypertension, and Intracranial Hemorrhage
Background: Adult-onset Still’s disease (AOSD) is a rare autoinflammatory condition characterized by severe systemic inflammation and multi-organ involvement. While pulmonary hyper...
Abstract 4370827: Artificial Intelligence Intervention versus Standard Care in Cardiovascular Disease Outcomes: A Rapid Systematic Review
Introduction: Cardiovascular disease (CVD) continues to be one of the leading causes of death worldwide. Early detection is crucial for identifying effective ways to improve CVD ou...
Abstract 4360838: Inhaled combusted cannabis use increases atherosclerosis risk in young people: A cross-sectional study
Background: Inhaled cannabis has been associated with increased risk of acute coronary events, yet the mechanisms remain unknown....
Abstract 4364779: Comparative Outcomes of Intra-Aortic Balloon Pump Versus Impella in Non-Myocardial Infarction Cardiogenic Shock: A National Inpatient Sample Database Analysis
Introduction: Temporary mechanical circulatory support (tMCS) devices such as intra-aortic balloon pump (IABP) and Impella are commonly used to stabilize patients with cardiogenic...
Abstract 4372236: Intravenous sotalol in pediatric cardiac intensive care patients compared to other antiarrhythmics: insights from a multicenter database
Background: Sotalol is an antiarrhythmic for which an intravenous (IV) form became available in 2015. Studies suggest it is safe and effective for treating pediatric arrhythmias, w...
Abstract 4348329: Evaluating the Cardiotoxicity of Novel Antibody Drug Conjugates Compared to Standard of Care Regimens for HER2 Positive Metastatic Breast Cancer: A Single Arm Meta-Analysis
Background: Novel antibody-drug conjugates (ADCs) such as trastuzumab-emtansine (T-DM1) and trastuzumab-deruxtecan (T-DXd) have shown efficacy in treating HER2-positive breast canc...
Abstract 4359878: Effect of mavacamten treatment by duration of obstructive hypertrophic cardiomyopathy diagnosis: Results from the EXPLORER cohort of MAVA-Long-Term Extension study
Introduction: Interim analyses from MAVA-LTE (NCT03723655) demonstrated that mavacamten is efficacious and well tolerated in patients with obstructive hypertrophic cardiomyopathy (...
Abstract 4371755: Menopausal Status and Inpatient Mortality in Medically Managed Type B Acute Aortic Dissection: An Insight from National Inpatient Sample Data(2016-2020)
Background: Type B acute aortic dissection (AAD) is often managed medically, with potential outcome differences by menopausal status due to hormonal and vascular factors. We evalua...
Abstract 4369560: Age-Stratified Clinical Characteristics in Spontaneous Coronary Artery Dissection (SCAD)- A Comparative Analysis from the iSCAD Registry
Introduction: Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome, especially in young and middle-aged women. Little is known about chara...
Abstract 4359428: Psoriasis Patients Have Elevated Levels of Lymphocyte-Platelet Aggregates Associated With a Distinct Platelet Inflammatory Transcriptome
Background: Psoriasis is a T-cell mediated inflammatory disease that is associated with elevated cardiovascular (CV) risk. Platelets are key players in psoriasis CV risk developmen...
Abstract 4366092: Cardiac MRI-Derived Right Atrial Function Impairment and Association with Outcomes in Arrhythmogenic Right Ventricular Cardiomyopathy
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) increases the risk of ventricular arrhythmias and heart failure. Cardiac MRI (CMR) offers a comprehensive assessm...
Abstract 4361990: A multi-proteomic Risk Score Predicts Adverse Cardiovascular Outcomes in Patients with Angina and Non-obstructive Coronary Artery Disease
Background: Angina with nonobstructive coronary arteries (ANOCA) has emerged as a significant contributor to major adverse cardiovascular events (MACE) and cardiovascular (CV) deat...
Abstract 4349971: New-Onset Atrial Fibrillation Exacerbates Mortality and Healthcare Burden in Orthotopic Liver Transplant Recipients Readmitted Within 90 Days
Introduction/Background: Atrial fibrillation (AF), a common postoperative arrhythmia, is associated with increased morbidity and mortality across various surgical populations. In p...