Circulation
Articles in this Issue
Abstract 4365121: Clinical Correlations with Serial Echocardiography and Global Longitudinal Strain in the First and Second Genetically Modified Porcine to Human Cardiac Xenotransplantation
Background: Our institution performed the first two genetically modified porcine cardiac xenotransplantation in humans, conducting serial longitudinal transthoracic echocardiograms...
Abstract 4361334: The company you keep: Cell-Cell Interactions Defined by 9p21 Risk Loci Change Interaction of iPSC derived VSMCs with Fibromyocytes
Introduction: Coronary artery disease (CAD) involves complex crosstalk of various cell types in the vasculature, key among them being vascular smooth muscle cells (VSMCs). Addition...
Abstract Or106: Beyond blood-brain barrier disruption and molecular weight: Compartmental kinetics of S100B and NSE for neurological prognostication after cardiac arrest.
Background: The prognostic value of serum biomarkers after out-of-hospital cardiac arrest (OHCA) depends on the timing, but the physiological basis for this temporal variation rema...
Abstract 4365901: Predictive Value of Patent False Lumen Extent for Postoperative Hypoxia in Acute Type A Aortic Dissection
Background: Acute type A aortic dissection (AAAD) is frequently complicated by severe respiratory failure due to acute lung injury, contributing to postoperative mortality. This st...
Abstract 4370519: Optimal LDL targets for overall survival in the heart transplant population
Background: High LDL cholesterol increases the risk of atherosclerotic cardiovascular disease and death in the general population. There is emerging evidence that low LDL levels (&...
Abstract 4372402: RyR2 diastolic calcium leak inhibition with <i>ent</i> -Verticilide improves diastolic dysfunction and reduces the risk of atrial fibrillation induction in murine models of hypertrophic cardiomyopathy.
Background: Hypertrophic cardiomyopathy (HCM) due to genetic variants in sarcomere genes is associated with severe diastolic dysfunction and a high risk of atrial fibrillation (AF)...
Abstract 4357163: Selective Reduction of Mitochondrial GAPDH in Left Ventricular Myocardium of Dogs with Heart Failure
Background: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme traditionally considered a housekeeping protein. Recent studies, however, suggest that GAPDH...
Abstract 4359662: Mortality Trends in Hypertensive Older Adults with Stroke: A CDC WONDER-Based Analysis (2000–2023)
Background: Stroke, a major cause of death and disability, is closely linked to hypertension. This study analyzes trends in mortality from stroke with hypertension as a contributin...
Abstract 4363051: Identification of functional proteins in peripheral artery disease using proteogenomic analysis of European and African populations
Background/Aims: Molecular mechanisms that potentiate atherosclerotic peripheral artery disease (PAD) outside of classical risk factors remain poorly understand. In this analysis,...
Abstract 4357082: Therapeutic effects of extracellular vesicles from hPSC-derived epicardial cells in myocardial infarct healing
Background: hPSC-derived epicardial cells (hEPs) have been demonstrated to promote infarct healing. However, the therapeutic potential of extracellular vesicles (EVs) secreted by h...
Abstract 4365257: Effect of Beta Blockers on Mortality in Takotsubo Syndrome: A Real-World Analysis of the TriNetX Global Collaborative Network Database
Background: Takotsubo syndrome (TTS) is characterized by transient left ventricular dysfunction that is strongly triggered by acute emotional or physical stress, although its exact...
Abstract 4342955: Impact of Fibromuscular Dysplasia on Clinical Outcomes Among Spontaneous Coronary Artery Dissection Patients: A Propensity-Matched Analysis Using the TriNetX Research Network
Introduction: Spontaneous coronary artery dissection (SCAD) is a significant cause of acute coronary syndrome in young women. Fibromuscular dysplasia (FMD) is frequently associated...
Abstract 4368072: CT Coronary Angiography vs Cardiac Catheterization and risk of Acute Kidney Injury – Comparative study
Backround: CT coronary angiography (CTCA) and invasive coronary angiography (ICA) are widely used to evaluate coronary artery disease (CAD). Both involve iodinated contrast, which...
Abstract 4370163: Carcinoid prevalence, outcomes, disparities, and COVID impact: Artificial intelligence-augmented propensity score national analysis of 124,954 hospitalizations from 2016-2022
Introduction: Artificial intelligence (AI) and wider digital technologies are accelerating healthcare systems’ attempts to address the financial and moral imperatives of improving...
Abstract 4366851: Utilization trends and outcomes of mechanical thrombectomy, catheter directed thrombolysis and systemic thrombolysis in patients with massive and submassive pulmonary embolism. An analysis of the National Inpatient Sample Database from 2017 to 2021
Introduction: Pulmonary embolism (PE) is associated with cardiovascular mortality, especially in massive and submassive casese requiring urgent intervention. Approximately 10% of s...
Abstract 4372169: Sex Differences in Exercise-Induced Diastolic Dysfunction in Patients without Evidence of Myocardial Ischemia
Background: We studied sex differences in exercise-induced diastolic dysfunction (Ex-DD) in patients undergoing exercise stress echocardiography (ExE) without myocardial ischemia....
Abstract 4369342: A single-center experience of oncology rehabilitation to facilitate cardiopulmonary fitness recovery among breast cancer patients receiving chemotherapy.
Background: Oncology rehabilitation (OR) may facilitate recovery of cardiopulmonary fitness (CRF) following cytotoxic chemotherapy in breast cancer (BC), however there is no consen...
Abstract 4342449: Effects of Cancer on Patients with Myocardial Infarction Complicated by Cardiogenic Shock: A Nationwide Inpatient Sample
Introduction: Cardiogenic shock (CS) is a serious complication following Type 1 myocardial infarction (T1MI). Being a hypercoagulable state, active cancer has been associated with...
Abstract 4363114: VAMP8 Dependent Platelet Secretion Drives Aortic Remodeling and Aneurysm Formation Through Platelet Reprogramming
Background: Platelets are emerging as active contributors to vascular pathology through the regulated release of granule-stored bioactive cargo. While platelet activation has been...
Abstract 4368729: Temporal progression of cardiac dysfunction in HFD+L-NAME model associated with metabolic impairment and mitochondrial functional defect.
Intro: The 2-hit HFD/L-NAME model is extensively used to develop new therapies for patients suffering from Heart failure with Preserved Ejection Fraction (HFpEF). It captures the f...
Abstract 4368127: Multi-Center Validation of an AI-Enhanced ECG Model for Predicting Echocardiographic Abnormalities: A Large-Scale Study Across 14 Tertiary Care Centers
Background: While numerous AI models leverage ECGs to predict specific cardiac abnormalities, few have been validated at scale across diverse populations and echocardiographic path...
Abstract 4361633: Incorporation of Genetic Risk Factors for Coronary Heart Disease into Clinical Risk Calculators Improved Risk Prediction in Three Major Race/Ethnicity Groups in the United States
Background: We investigated the impact of genetic risk factors for coronary heart disease (CHD) -polygenic risk score (PRS), familial hypercholesterolemia (FH), and family history...
Abstract 4336766: Patient Experience Following Pulsed-Field Ablation Compared to Radiofrequency Ablation for Atrial Fibrillation
Background: Pulsed-field ablation (PFA) for atrial fibrillation (AF) offers several advantages compared to thermal ablation, however direct comparisons of patient-reported outcomes...
Abstract 4360655: Targeting Dedicator of Cytokinesis 2 Preserves Cardiac Function by Reprogramming Post-Infarction Inflammation and Metabolism
Myocardial infarction(MI) is a leading cause of heart failure and death. Beyond the initial ischemic insult, persistent inflammation and metabolic dysfunction critically impair recovery from the MI, h...
Abstract 4364773: Collagen Type XVIII Alpha Chain 1 Regulates the Progression to Heart Failure with Preserved Ejection Fraction
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome marked by reduced diastolic filling due to pathological cardiomyocyte and fibrotic remod...