Circulation
Articles in this Issue
Abstract 4373550: Efficacy and Safety of Sedative Hypnotic Induction Agents on Perioperative Outcomes in Coronary Artery Bypass Grafting: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
Background: Choice of sedative–hypnotic agents can affect intraoperative and postoperative outcomes; however, comparative studies in adult coronary artery bypass grafting (CABG) ar...
Abstract 4367510: Increased Skeletal Muscle Mass Normalizes Cardiac Metabolic Pathways and Attenuates Left Ventricular Hypertrophy and Diastolic Dysfunction in Hypertrophic Cardiomyopathy
Background: Emerging evidence shows that key features of HCM—left-ventricular hypertrophy (LVH), diastolic dysfunction, and impaired cardiac energetics—are linked to systemic metab...
Abstract 4370616: Impact of a Cardiogenic Shock Team Approach on Outcomes in a Non-LVAD Center
Introduction: Cardiogenic shock (CS) is a high-mortality clinical syndrome, with reported rates between 40–50%. Multidisciplinary shock teams have emerged to streamline care and im...
Abstract 4373501: Impact of Social Determinants of Health on the Utilization of Permanent Pacemakers in Patients with Sick Sinus Syndrome: A National Inpatient Sample Analysis 2016–2021
Background: Social determinants of health (SDOH) influence access to advanced cardiac interventions. We aimed to evaluate the association between SDOH and permanent pacemaker (PPM)...
Abstract Sun706: Association of Diastolic Blood Pressure Trends and Thresholds with Return of Spontaneous Circulation Across Full CPR Duration
Introduction: Pediatric resuscitation guidelines support using diastolic blood pressure (DBP) as a marker of CPR quality. However, studies establishing DBP thresholds (≥25 mmHg in...
Abstract 4365916: The “Buddy-Wire” Technique: Navigating Complex Anatomy to Guide Placement of an RP Impella
Introduction/Background: Microaxial flow devices such as Impella RP provide a temporary therapeutic approach for managing acute RV failure. However, the use of parallel stiff wires...
Abstract 4367152: VANQUISH-2: Phase 3, Randomized, Double-blind, Placebo-controlled, Trial of weekly subcutaneous administration of VK2735 in Obese or Overweight Adults with Type 2 Diabetes
Background: The incidence of diabetes mellitus (DM) continues to rise and is one of the most prevalent and costly chronic diseases worldwide. Diabetes, obesity, and cardiovascular...
Abstract 4362524: Mortality Trends Among Insulin-Dependent Diabetics Developing Ischemic Heart Disease: A CDC Wonder Retrospective Analysis 1999-2023
Background: Ischemic heart disease (IHD) is one of the most common causes of sudden cardiac death, with insulin-dependent diabetes mellitus (IDDM) affected patients emerging with m...
Abstract 4370397: Prognosis of Cardiovascular-Kidney-Metabolic (CKM) Stages: The Dallas Heart Study
Background: The recent AHA presidential advisory on Cardiovascular-Kidney-Metabolic Syndrome (CKM) proposed a novel staging scheme, but limited data exist regarding the association...
Abstract 4371442: Aspirin Shows Comparable Efficacy to Other Antithrombotic Strategies in Preventing Recurrent Stroke in Patients with Aortic Arch Atheroma: A Systematic Review
Introduction: Atherosclerotic plaques ≥4 mm in the aortic arch are strongly associated with recurrent stroke, particularly in cases of undetermined etiology. Guidelines such as the...
Abstract 4364326: Right Atrial Longitudinal Strain Phenotypes in Patients with Systemic Sclerosis
Background: Right ventricular diastolic dysfunction (RVDD) is a critical yet underrecognized driver of morbidity and mortality in systemic sclerosis (SSc), with gold-standard asses...
Abstract 4365660: Multimodal Artificial Intelligence Improves the Yield of Nuclear Cardiac Amyloid Testing in Suspected Transthyretin Amyloid Cardiomyopathy: a Report from the TRACE-AI Network
Introduction: Artificial intelligence (AI) applied to single cardiovascular diagnostic modalities is an emerging approach for the scalable screening of transthyretin amyloid cardio...
Abstract 4359992: Intervention to Increase Screening and Treatment of Iron Deficiency in Heart Failure Patients in the Acute Care Setting
Patients with heart failure with reduced ejection fraction are at high risk for iron deficiency (ID) due to low intake and high losses. Randomized controlled trials show intravenous (IV) iron improves...
Abstract 4371916: Transcarotid Artery Revascularisation (TCAR) versus Transfemoral Carotid Artery Stenting (TFCAS) versus Carotid Endarterectomy (CEA) for Treatment of Carotid Artery Stenosis: A Systematic Review and Network Meta-Analysis of Intra-Hospital Mortality and Stroke
Introduction: Carotid artery stenosis (CAS) is a significant cause of stroke, and its optimal surgical management remains debated. While carotid endarterectomy (CEA) has been the g...
Abstract 4367111: Successful Intracardiac Radiofrequency Ablation of Recurrent Subaortic Membrane Causing LVOT Obstruction
Background: Subaortic membrane (SAM) is a fibromuscular ridge beneath the aortic valve that causes fixed left ventricular outflow tract (LVOT) obstruction. Surgical resection is th...
Abstract 4365882: Divergent Transcriptomic Responses in Liver and Colon after ECMO resuscitation in an Infant Piglet Model
Introduction and Background: Pediatric patients on ECMO therapy often experience multiorgan dysfunction, including liver injury and intestinal mucosal disruption. RNA sequencing (R...
Abstract 4348497: Adverse Cardiovascular Outcomes in the Postpartum Period Associated with Upbringing-Related Social Determinants of Health
Background: Social determinants of health (SDOH), particularly those related to upbringing (ICD-10: Z62), are increasingly recognized as potential contributors to adverse maternal...
Abstract 4366463: Left Atrial Posterior Wall Isolation Plus Pulmonary Vein Isolation vs. Pulmonary Vein Isolation Alone by Pulsed Field Ablation for Persistent Atrial Fibrillation: A Meta-Analysis
Background: Pulsed field ablation (PFA) is an emerging energy source in catheter ablation for atrial fibrillation (AF), offering tissue selectivity and procedural efficiency. While...
Abstract 4372979: AI-Powered Handheld Ultrasound for Rapid Left Ventricular Assessment: A Systematic Review and Meta-Analysis
Background: Handheld ultrasound (HHU) is increasingly used in emergency and point-of-care settings for cardiac assessment. The integration of artificial intelligence (AI) into HHU...
Abstract 4367885: Global Trends in Maternal Hypertensive Disorders-Associated Mortality from 2000 to 2019.
Background: Maternal hypertensive disorders-associated mortality is a major cause of maternal deaths. This study evaluated the global, regional, country, and age-specific maternal...
Abstract Sat1401: Two-Decade Trends in Cardiac Arrest Mortality Among U.S. Adults With Septicemia: Analysis of CDC Data (1999–2024)
Background: Septicemia often results in cardiovascular collapse and cardiac arrest (ICD-10 I46); however, national mortality trends within this population are not yet thoroughly an...
Abstract 4339651: The Efficacy and Safety of Plozasiran on Lipid Profile in Dyslipidemic Disorders: A Systematic Review and Meta-Analysis
Background: Dyslipidemias raise the risk of cardiovascular disease and other conditions like fatty liver and pancreatitis. A promising therapeutic target is apolipoprotein C-III (A...
Abstract 4345450: Race Interaction for Association Between Neighborhood Walkability and Community Distress and 5-year Major Amputation Outcomes in Patients With Peripheral Artery Disease Following Peripheral Vascular Intervention
Background: The impact of neighborhood walkability on peripheral artery disease (PAD) outcomes remains understudied, despite walking being the first line of treatment for PAD and e...
Abstract 4366555: Artificial Intelligence to Extract Structured Details from Unstructured Medical Records in a Global Heart Failure Trial
Background: Global clinical trials collect extensive unstructured medical records that richly describe participants’ clinical presentation, but their narrative format precludes qua...
Abstract 4363848: Association of Residential Green Space, Blue Space, and Natural Environment with the Incident Heart Failure and Cardiac Morpho-Functional Phenotypes: a UK Biobank-based Prospective Cohort and Imaging Study
Background: Environmental exposures are increasingly recognized as modifiable risk factors for heart failure (HF), yet the roles of residential green space, blue space, and natural...