Circulation
Articles in this Issue
Abstract 4348199: Sex-based Differences of Risk Factors Associated with Cumulative Limb Amputation in Thromboangiitis Obliterans (Buerger’s Disease)
Backgroud: Thromboangiitis obliterans (TAO) is a rare, nonatherosclerotic, inflammatory disease that usually onsets in young male patients with heavy smoking. Up to 1/3 of patients...
Abstract 4367930: Trends in Cardiovascular Mortality Among Adults in United States With Sleep Disorders, 1999–2020: A CDC WONDER-Based Analysis
Background: In the United States, Cardiovascular Disease (CVD) is a leading cause of mortality, particularly among individuals with sleep disorders. This national analysis (1999–20...
Abstract 4369109: Association of Cardiac Magnetic Resonance-Derived Myocardial Strain with Adverse Outcomes in Patients with Hypertrophic Cardiomyopathy and Preserved Systolic Function
Background: Cardiac magnetic resonance (CMR) feature tracking enables non-invasive quantification of myocardial strain. In hypertrophic cardiomyopathy (HCM) with preserved ejection...
Abstract 4371135: A Rare Case of Acute Undifferentiated Leukemia Presenting as an Isolated Cardiac Mass
A 65-year-old male with history of coronary artery disease with percutaneous coronary intervention six months earlier presented with one month of fevers, night sweats, chest pain, muscle aches, fatigu...
Abstract 4365510: Platelet-derived growth factor antagonist antibody attenuates pulmonary arterial hypertension and prevents right heart dysfunction in the Sugen-Hypoxia rat model
Background: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling and elevated pulmonary artery pressure that leads to right ventricular (RV) fail...
Abstract Sat802: Sociocultural Barriers to Effective Bystander CPR: Challenges and Opportunities for Community-Based Education Programs
Introduction: Bystander cardiopulmonary resuscitation (bCPR) can double or triple survival yet only 40% of out-of-hospital sudden cardiac arrest (SCA) victims receive bCPR before p...
Abstract 4366183: Development of a High-Throughput Drug Screening Platform to Identify Novel Therapeutics for Long QT Syndrome
Background: Long QT syndrome (LQTS) is a potentially lethal cardiac channelopathy that stems primarily from pathogenic variants in KCNQ1 (LQ...
Abstract 4370321: Non-invasive Hemodynamics for diabetic care with HEMOTAG
Introduction: Cardiac Time Intervals (CTIs), derived from mechanical events of the cardiac cycle, offer valuable insights into myocardial performance and hemodynamics. With advance...
Abstract 4365128: Sex-Differences in Left Ventricular Function Recovery After COVID-19-Related Myocarditis Confirmed by MRI or Biopsy
Background: COVID-19 and, more rarely, its mRNA vaccination have been associated with myocarditis, often with greater incidence and severity in males. Long-term outcomes, such as r...
Abstract 4341730: Atherosclerosis composition plaque in carotid arteries associated with cerebrovascular lesions: An autopsy study.
Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Within CVDs, cerebrovascular diseases (CeVDs) share risk factors with both stroke and dementia....
Abstract 4371516: Hemoglobin and suPAR Predict 5 Year MACE in Men but Not Women with HFpEF and Coronary Artery Disease
Introduction: Heart failure with preserved ejection fraction (HFpEF) shows clear sex differences in pathophysiology and outcomes, but it is unknown circulating biomarkers major adv...
Abstract 4365098: Immediate/Initial Orthostatic Hypotension: Gravity Triggers Blood Pressure Drop with Upright Posture While Sympathetic Activation Drives Recovery
Background/Introduction: Immediate/Initial orthostatic hypotension (iOH) presents as an abnormal transient blood pressure (BP) decrease immediately upon assuming upright posture, w...
Abstract 4353187: Platypnea-Orthodeoxia Syndrome Triggered by Acute Lung Injury and Mechanical Ventilation in a Patient with Known Patent Foramen Ovale: A Case of Pulseless Electrical Activity Arrest from Dynamic Shunting
Introduction: Patent foramen ovale (PFO) is present in ~25% of adults and is typically asymptomatic. Two indications for PFO closure include cryptogenic stroke and platypnea-orthod...
Abstract 4343917: Myocardial stiffness properties are improved in heart failure with preserved ejection fraction (HFpEF) in pigs by a regular exercise regime
Background: Left ventricular (LV) pressure overload (LVPO) causes LV hypertrophy and resistance to LV filling, notably increased LV chamber stiffness and LV myocardial stiffness (K...
Abstract 4367390: Trend in the Utilization of Colchicine For Coronary Artery Disease In the United States Over the Past Decade: Insights From Real-World Data
Introduction: Colchicine has emerged as a promising anti-inflammatory therapy for secondary prevention in coronary artery disease (CAD). Despite growing evidence supporting its car...
Abstract 4359699: Impact of Surgical Selection on Stroke and Survival in Aortic Arch Aneurysm: A Risk-Adjusted Comparison Between Total Arch Replacement and Thoracic Endovascular Aortic Repair Using Najuta
Objective: The aim of this study was to compare clinical outcomes between total arch replacement (TAR) and thoracic endovascular aortic repair (TEVAR) using Najuta in patients with...
Abstract 4369579: Loss of G Protein-Coupled Receptor Kinase 2 S-Nitrosylation Abolishes Beta 3 Adrenergic Receptor-Mediated Cardioprotection Evidence from Functional and Proteomic Analyses
Background: G Protein-Coupled Receptor Kinase 2 (GRK2) contributes to cardiac dysfunction through β-Adrenoceptor (βAR) desensitization following its upregulation. Inhibition of GRK...
Abstract 4370041: Sodium-Glucose Cotransporter 2 Inhibitor on Atrial Fibrillation Recurrence after Catheter Ablation; A Systematic review and Meta-analysis.
Background: Recurrence of atrial fibrillation (AF) remains a concern even after catheter ablation. The impact of Sodium-Glucose Cotransporter 2 Inhibitor (SGLT2i) on Atrial tachyar...
Abstract 4366635: Clonal hematopoiesis of indeterminate potential in coronary disease patients: a 24-year follow-up
Cardiovascular disease (CVD) is highly prevalent and remains a cause of great morbi-mortality worldwide. Growing evidence suggests clonal hematopoiesis of indeterminate potential (CHIP) as an independ...
Abstract 4366089: Sex-Dependent Regulation of CYP2E1 Correlates with Changes in Energy Homeostasis in Mice Deficient for GDF15 in Brown Adipose Tissue
Introduction: Obesity is a major risk factor for various diseases and the clinical manifestations of obesity vary between sexes.Studies have shown that DIO induces GDF15 levels in...
Abstract 4345726: Imatinib Mesylate and Sirolimus Inhibit Fibrogenic Activation of Endocardial Endothelial Cells
Background: Clinically, Imatinib mesylate, a tyrosine kinase pathway inhibitor, and sirolimus, an mTOR inhibitor, are used as antiproliferative agents for the treatment of fibroela...
Abstract 4363871: Immediate versus Deferred Stenting in Acute Myocardial Infarction: A Systemic Review and Meta-Analysis of Randomized Controlled Trials
Background: The timing of stent placement in acute myocardial infarction (AMI) remains a subject of clinical debate. Immediate stenting is widely practiced, while deferred stenting...
Abstract 4367606: Racial, Gender, and Regional Disparities in Peripheral Arterial Disease–Related Mortality Among Hypertensive Adults in the United States: A 1999–2020 CDC WONDER Analysis
Introduction: Peripheral Arterial Disease (PAD) is a prevalent condition associated with considerable morbidity and mortality, a burden that is further intensified by the frequent...
Abstract 4361303: Impact of Repaired Congenital Heart Defect on Inpatient Outcomes Among Hospitalized Patients Following Catheter Ablation Procedure
Background: Catheter ablation is a common procedure carried out in patients with repaired congenital heart defects due to indications such as atrial and ventricular arrhythmias. We...
Abstract 4360978: <i>CVSN Best Abstract Award:</i> Longitudinal Associations of Childhood Maltreatment and Social Support with Sleep Duration Trajectories from Adolescence to Adulthood
Background: Promoting sleep health is critical for cardiovascular disease prevention. Few longitudinal studies have examined whether childhood maltreatment influences sleep duratio...