Circulation
Articles in this Issue
Abstract 4367021: Intermittent Complete Heart Block as a Manifestation of Noncompaction Cardiomyopathy in a Young Adult
Description of Case: A 36-year-old male with a history of intermittent palpitations and shortness of breath was referred for cardiology evaluation after an event monitor captured a...
Abstract 4359798: A 50% or Greater Reduction in LDL-Cholesterol Is Associated with Improved Long-Term Outcomes and Lower Health Care Utilization After Myocardial Infarction - a SWEDEHEART study
Background: Numerous clinical trials have established that low-density lipoprotein cholesterol (LDL-C) is among the strongest causal modifiable risk factors for cardiovascular (CV)...
Abstract 4367122: Radiomics Analysis of CMR Cine and LGE Images Accurately Diagnoses Genetic Cardiomyopathy Relative to Cardiac Sarcoidosis and Non-Genetic Myocarditis
Introduction/Background: Genetic cardiomyopathy (GEN-CM) has overlapping features of inflammation and arrhythmias with cardiac sarcoidosis (CS) and non-genetic myocarditis (MYOC);...
Abstract 4372171: Analysis of Burden and Prevalence of Pulmonary Artery Hypertension across 32-years: An analysis for the Global Burden of Disease 2021
Introduction: Pulmonary arterial hypertension (PAH) is a rare yet progressive condition marked by elevated pulmonary vascular resistance, leading to right heart failure and increas...
Abstract 4365485: Impact of Socioeconomic Status on All-Cause Mortality in Older Adults with Heart Disease: a Community-based Cohort Study in China
Background: Socioeconomic status (SES) influences the risk of heart disease (HD) in the general population. Yet, few community-based studies have assessed the impacts of various SE...
Abstract 4363940: Epidemiology and Cardiovascular Implications of Preclinical and Clinical Obesity: Insights from the UK Biobank
Background: Obesity is a major contributor to cardiovascular disease (CVD). Historically, obesity was defined by body mass index (BMI), but this metric has low sensitivity with bod...
Abstract 4358090: DCLK1 Deficiency Maintains Smooth Muscle Cell Contractile Phenotype via Suppressing TRIM21-Mediated Autophagy
Background: Phenotypic switching of vascular smooth muscle cells (VSMCs) greatly contributes to vascular remodeling in various vascular diseases. The underlying molecular mechanism...
Abstract 4371829: Efficacy of Bempedoic Acid Versus Placebo for Additional Lipid Lowering in Patients Receiving Background Statin Therapy: A Meta-Analysis of Randomized Controlled Trials
Introduction: Bempedoic acid, an oral ATP-citrate lyase inhibitor, is indicated as an adjunct to maximally tolerated statin therapy for patients with atherosclerotic cardiovascular...
Abstract 4362699: Association of Gillmore score with presence and development of atrial fibrillation at 1 year in a large, real-world cohort of patients with transthyretin amyloid cardiomyopathy
Introduction: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a disease of misfolded transthyretin deposition into cardiac structures, very commonly causing arrythmias. Reports f...
Abstract 4369405: Comparative Cardiac Safety of Bruton Tyrosine Kinase Inhibitors: A Bayesian Network Meta-Analysis
Background: Bruton tyrosine kinase inhibitors (BTKi) are essential in managing B-cell malignancies, but cardiac toxicity remains a major concern. Ibrutinib, the first-in-class agen...
Abstract 4366549: FNDC1 is Implicated in Small and Large-vessel Arterial Disease and Induces Vascular Calcification via PI3K/AKT Signaling and the NAD Salvage Pathway
Introduction: Vascular calcification is a major contributor to cardiovascular morbidity and mortality, yet the molecular mechanisms of calcification remain poorly defined....
Abstract 4370528: C-Reactive Protein and Long-Term Risk of Stroke in Patients with Myocardial Infarction
Background: Patients with myocardial infarction (MI) are at increased risk of ischemic stroke (IS). We previously showed that the biomarker C-reactive protein (CRP) is associated w...
Abstract 4363796: Results of a pacing program with re-sterilized pacemakers: 18,615 lives saved across 29 countries over 50 years.
Introduction: Significant disparities remain between high-income countries and low- and middle-income countries (LMICs) in access to pacemaker therapy. In LMICs, the high cost of d...
Abstract 4366920: A Remedy for the Heart and the Hemoglobin: Improvement in Anemia Post Transcatheter Aortic Valve Replacement
Background: Aortic stenosis (AS) affects nearly 0.4% of the US population. Among this cohort, anemia is a significant comorbidity, affecting 30-45% of patients. This is thought to...
Abstract 4363200: A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Monthly or Quarterly Subcutaneous Administration of the Interleukin-6 Inhibitor Pacibekitug in Patients With Elevated High-Sensitivity C-Reactive Protein and Chronic Kidney Disease: 90-Day Analyses from TRANQUILITY
Introduction: Existing evidence supports the cardiovascular disease (CVD) therapeutic potential of blocking interleukin-6 (IL-6). Pacibekitug is a long-acting, fully human monoclon...
Abstract 4346523: Enrollment Trends and Demographic Representation in Valvular Heart Disease Interventional Trials from 2000 to 2024: A Systematic Review
Introduction: Valvular heart disease (VHD) poses a growing global burden, particularly in aging populations. While transcatheter interventions have expanded rapidly over the past t...
Abstract 4344584: Healthcare-related social determinants of health are associated with pain severity among adults with comorbid heart failure and chronic pain
Introduction: Chronic pain worsens symptom burden, physical function, and quality of life in heart failure (HF). Social determinants of health (SDOH) can shape the trajectory of HF...
Abstract 4366596: Troponin I and Cardiac Remodeling in Male Basketball Players: An Integrated Strategy for Sudden Cardiac Death Risk Using ECG, Imaging, and Biomarkers – A Systematic Review and Meta-Analysis
Background: Sudden cardiac death (SCD) remains an intriguing and devastating event among competitive athletes, disproportionately affecting male basketball players (MBP), prominent...
Abstract 4366087: Smad1 Signaling Stimulates a Regulatory Infarct Myofibroblast Subpopulation and Protects the Heart from Adverse Remodeling.
Introduction and Hypothesis: Cardiac fibroblasts and myofibroblasts drive post-myocardial infarction (MI) repair, remodeling, and fibrosis. TGF-β superfamily members exert pro-repa...
Abstract 4367907: Deep Learning-based OCT-FLIm Imaging for Quantitative Assessment of Plaque Compositions
Introduction: Fluorescence lifetime imaging (FLIm) integrated with optical coherence tomography (OCT) enables compositional assessment of atherosclerotic plaques. However, the lack...
Abstract 4357937: Lipid-Related Polygenic Risk Score and Its Association with Plaque Rupture versus Erosion: Insights into the Role of Lipids in the Pathogenesis of Unstable Plaque Morphologies
Background: Distinct plaque morphologies underlie the major causes of acute coronary syndrome (ACS) and sudden coronary death. We used polygenic risk scores (PRSs) for hypercholest...
Abstract 4369887: Online Cognitive Behavioral Therapy for Depressed Rural Cardiac Patients: Effective Regardless of Health Literacy Level.
Introduction: Rural-dwelling adults with cardiovascular disease and failure have high rates of depression. However, delivering interventions that are both effective and accessible...
Abstract 4371563: Left Atrial Appendage Strain as a Predictor of Energy Required for Successful DC Cardioversion in Patients With Atrial Fibrillation.
Background: Left atrial appendage strain (LAAS) is a novel echocardiographic parameter that reflects atrial function. Emerging evidence suggests its prognostic relevance in atrial...
Abstract 4368747: Impact of catheter ablation on prognostic outcomes in electrical storm
Background: Electrical storm (ES) is associated with high mortality and may lead worsening of heart failure or repeat ICD therapy deliveries. Catheter ablation of ventricular tachy...
Abstract 4365146: Impact of Timing of Atrial Fibrillation Ablation on Outcomes in Patients with HFpEF and HFrEF
Background: Early catheter ablation for atrial fibrillation (AF) improves outcomes, but the optimal timing, especially in heart failure (HF) subtypes, remains unclear....