Abstract 4370519: Optimal LDL targets for overall survival in the heart transplant population

Abstract

Background: High LDL cholesterol increases the risk of atherosclerotic cardiovascular disease and death in the general population. There is emerging evidence that low LDL levels (<70mg/dL) may be associated with higher all-cause mortality in the heart transplant population. Although the International Society for Heart and Lung Transplantation (ISHLT) recommends an LDL level below 100 for most transplant patients, there are currently no guidelines for targeted LDL levels in this population. Hypothesis: This study aims to determine optimal LDL levels at 1-year post-transplantation that are associated with reduced all-cause mortality. Methods: This is a single-center retrospective study of adult post-heart transplantation patients. The Tufts Heart Transplant Repository was used to collect data to the time of last follow up or death. Patients were excluded if they did not have a one-year post-transplantation follow up visit with LDL measurement, drawn within 90 days before and after the anniversary of their transplantation date. We performed a Cox proportional hazard model with a primary endpoint of all-cause mortality with LDL as both a binary (<100mg/dL or >100mg/dL) and a continuous variable. Additionally, restricted cubic spline curves were used to model the relationship between LDL and all-cause mortality at the time of transplantation and at one-year post-transplantation. Results: This study included 237 patients. Mean LDL at one year was 82mg/dL, and 75% of patients had LDL <100mg/dL at one year. There was no difference in all-cause mortality in patients with LDL <100mg/dL compared to those with LDL >100mg/dL (p=0.553) at one-year post-transplantation. There was no association between LDL and all-cause mortality with LDL as a continuous variable (p=0.507). The cubic spline model of LDL at one-year post-transplantation revealed a U-shaped curve, with a non-statistically significant increase in mortality risk with LDL <71mg/dL and >130mg/dL. A cubic spline of LDL at the time of transplantation revealed a similar curve with inflections at 71mg/dL and 150mg/dL. Conclusion: This observational cohort study shows no mortality benefit to maintaining LDL <100mg/dL, and no statistically significant relationship between LDL one-year post-transplantation and all-cause mortality. It does suggest a trend toward better outcomes with LDL between 70 and 130mg/dL. Further study is needed to better define the LDL targets in this population.