Circulation
Articles in this Issue
Abstract 4366745: Artificial Intelligence-Derived Myosteatosis on Coronary Artery Calcium CT Scans Predicts Incident COPD: An AI-CVD Study within the Multi-Ethnic Study of Atherosclerosis (MESA)
Introduction/Background: Myosteatosis, defined as pathological fat infiltration into skeletal muscle, is an emerging marker of metabolic dysfunction and cardiovascular risk, partic...
Abstract 4357636: Pharmacological Inhibition of GPR39 Markedly Reduces Brain Infarction in a Mouse Model of Middle Cerebral Artery Occlusion
Background: GPR39 is abundantly expressed in all brain regions. We have previuosly demonstrated that it is present in vascular smooth muscle cells and pericytes where its activatio...
Abstract 4364789: DNA Methylation Strongly Predicts Level of Coronary Artery Obstruction and Ischemia with No Obstructive Coronary Artery Spectrum Presentations in those with Acute Coronary Syndrome.
Introduction: Over the past decade, there has been increasing recognition of Ischemia with No Obstructive Coronary Arteries (INOCA) and myocardial infarction with No Obstructive Co...
Abstract 4359122: Hypothalamic CRH Neurons Regulate Cardiac Function and Peripheral Immunity Following Myocardial Infarction
Background: Myocardial infarction (MI) is a leading cause of mortality worldwide and is often followed by poor prognosis, with many patients progressing to ischemic heart failure....
Abstract 4369427: Policy Optimization for Dynamic Heart Transplant Allocation
Introduction: The current US adult heart allocation policy has several limitations, including being heavily focused on device utilization rather than individual patient illness sev...
Abstract 4342529: Regional Differences in Outcomes in Adults after Percutaneous Coronary Intervention (PCI) for Stable Ischemic Heart Disease
Background: Previous studies on Percutaneous Coronary Intervention (PCI) for Acute Coronary Syndrome (ACS) have found a disparate distribution of healthcare resources across U.S. r...
Abstract 4355982: EHD1 enhances macrophage inflammation to exacerbate the progression of atherosclerosis
Background: Atherosclerotic cardiovascular disease (ASCVD), a chronic inflammatory disease, is the leading cause of morbidity and mortality worldwide. Macrophages play a central ro...
Abstract 4360855: Advanced Mapping Techniques for Atrioventricular Nodal Reentrant Tachycardia in Pediatric Patients: Do They Make a Difference?
Introduction: Catheter ablation for atrioventricular nodal reentrant tachycardia (AVNRT) traditionally used a combination of anatomic and signal morphology mapping. Newer advanced...
Abstract 4366024: Development and Validation of an Interpretable Prediction Model for IVIG-Resistant Kawasaki Disease: A Multicenter Cohort Study
Background: The early identification and prediction of intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients remain essential for mitigating the incidence of c...
Abstract 4370095: Cardiometabolic Multimorbidity and Functional Decline in Older Adults: Moderating Effects of Physical Activity, Sex, and Race/Ethnicity
Introduction: Cardiometabolic conditions, including heart disease (ischemic heart disease or heart failure; HD) and diabetes mellitus (DM), are associated with accelerated function...
Abstract 4358118: Mitochondrial dynamics modulators promoted favorable patterns of cardiac metabolic reprogramming in doxorubicin-induced heart failure
Background: Doxorubicin is an effective chemotherapeutic agent for various types of cancer. Unfortunately, the clinical utilization of doxorubicin is limited due to doxorubicin-ind...
Abstract 4371094: Prevalence of Cardiac Arrhythmias and Conduction Abnormalities in Patients with Vascular Ehlers-Danlos Syndrome: A Retrospective Cohort Study
Introduction: Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder caused by pathogenic variants in the COL3A1 gene,...
Abstract 4363872: Acoramidis Improved Clinical Outcomes, Function, Quality of Life and NT-proBNP in Patients With Transthyretin Amyloid Cardiomyopathy Regardless of Atrial Fibrillation Status at Baseline
Background: Atrial fibrillation (AF) significantly impacts quality of life (QoL) and is often observed in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). Acoramidis a...
Abstract 4367626: Prospective Validation of opportunistic screening for Chagas disease using Artificial Intelligence-enabled ECG: the SaMi-Trop Project
Introduction: Patients with Chagas disease (ChD) encounter numerous barriers to receiving timely diagnosis, treatment, and follow-up care: fewer than 10% of infected individuals ar...
Abstract 4366867: The Cardiac Transcription Factor NFATC1 is a Key Regulator of Cardiac Excitability
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, contributing to substantial morbidity and mortality. Thus, there is a...
Abstract 4341846: Systemic Inflammation Is Associated with Major Adverse Cardiovascular Events in Patients with Established Atherosclerotic Cardiovascular Disease and Stage 3-4 Chronic Kidney Disease
Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality in the United States, affecting over 26 million people. Further, patients w...
Abstract 4367243: Comparative Effects of Tirzepatide vs Semaglutide on 1-Year Mortality and Cardiovascular Outcomes in T2DM Patients with HFpEF
Background: Patients with type 2 diabetes mellitus (T2DM) and heart failure with preserved ejection fraction (HFpEF) are at increased risk for adverse cardiovascular outcomes. Gluc...
Abstract 4357805: Guideline-directed medical therapy's effect on systolic function in patients with heart failure and left bundle branch block
Background: The current guidelines recommend at least 3 months of optimal guideline-directed medical therapy (GDMT) for patients with heart failure and left bundle branch block (LB...
Abstract 4370783: Kounis Syndrome: A Rare but Noteworthy Cause of Acute Coronary Syndrome
Kounis syndrome (KS) is a dangerous and rare acute coronary syndrome elicited in the setting of an allergic, hypersensitivity, or anaphylactic reaction. The syndrome is caused by mast cell activation...
Abstract 4360112: Ketones as an Optimal Substrate in Single Ventricle Heart Disease
Introduction: Heart failure (HF) is a common morbidity in children with single ventricle heart disease (SVHD). Unfortunately, there are no proven treatments for SVHD associated HF....
Abstract 4372945: The Japanese nationwide survey of the anomalous aortic origin of a coronary artery in children over 20 years
Background: Anomalous aortic origin of a coronary artery (AAOCA) is rare but is one of the most important causes of sudden cardiac death in children with a variety of presentations...
Abstract 4369480: Carotid Occlusion and Thrombolysis: A New Paradigm Shift in Stroke Management
Introduction: Carotid artery occlusion due to plaque rupture carries a high risk of stroke, yet current guidelines do not recommend intervention for occluded or trickle-flow caroti...
Abstract 4363073: Somatic activating mutation in Phosphoinositide 3-kinase in a plexiform lesion of a patient with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension
Background: Hereditary hemorrhagic telangiectasia (HHT) and hereditary pulmonary arterial hypertension (HPAH) are genetic diseases that affect the pulmonary vasculature. HHT and HP...
Abstract 4370694: Longitudinal Evaluation of Anti-Arrhythmic Drug Use to Predict Hospitalization or Death in Patients with Ventricular Tachycardia
Introduction: Anti-arrhythmic drugs in patients with VT are chosen based on comorbidity profile. However, the relationship between comorbidity profile, selection of drugs and hard...
Abstract 4360076: Risk of Acute Systolic Heart Failure Following Respiratory Syncytial Virus Compared to Influenza: A Multi-Institutional Retrospective Cohort Study
Background: Respiratory syncytial virus (RSV) has been historically underrecognized as a contributor to non-pulmonary complications in adults. Emerging evidence suggests that RSV,...