Circulation
Articles in this Issue
Abstract 4372906: Impact of Maternal Gestational Diabetes on Offspring Cardiac Function: A Systematic Review and Meta-Analysis
Background: Gestational diabetes mellitus (GDM) affects 6–12% of pregnancies globally and is linked to adverse fetal cardiac remodeling. Offspring exposed to GDM in utero show alte...
Abstract 4361267: Predictors of Mortality Among Hospitalized Patients Post Catheter Ablation Procedures and Associated Cardiac Tamponade
Background: Catheter ablation, a commonly performed procedure in the electrophysiology laboratory, is relatively safe. However, complications like pericardial tamponade, although r...
Abstract 4366496: Muscarinic Acetylcholine Receptor 3 Knockout is Associated with Salt Sensitive Hypertension
Introduction: Hypertension ( HTN ) is characterized by reduced vascular contractility and nitric oxide ( NO...
Abstract 4368754: A Platelet Transcriptomic Signature Predicts Cardiovascular Risk in Peripheral Artery Disease
Background: Patients with peripheral artery disease have a markedly increased risk of cardiovascular morbidity and mortality. While platelets are key mediators in the pathogenesis...
Abstract 4367379: Early Re-Initiation of Optimal Guideline-Directed Medical Therapy after Coronary Artery Bypass Grafting in Patients with Heart Failure with Reduced Ejection is Associated with Decreased Mortality
Introduction: Guideline-directed medical therapy (GDMT) improves survival in medical patients with heart failure with reduced ejection fraction (HFrEF). For cardiac surgical patien...
Abstract 4368943: Axillary/Subclavian IABP Is a Safe and Effective Support in Advanced Heart Failure: A Meta-Analysis
Introduction: Axillary intra-aortic balloon pumps (IABPs) represent an emerging approach to support patients with advanced heart failure, particularly those awaiting heart transpla...
Abstract 4357929: Isolated Polyvalvular Heart Disease Associated with a TAB2 Variant: Expanding the Phenotypic Spectrum of TAB2-Related Cardiovascular Disease
Polyvalvular heart disease (PVD) has historically been associated with syndromic conditions such as Trisomy 13, Trisomy 18, and connective tissue disorders. Emerging evidence suggests that rare, singl...
Abstract 4362755: Macrophage Extracellular Traps In Myocardial Tissue Are Associated With Adverse Clinical Outcomes In Patients With Heart Failure
Introduction: The immune system, particularly bone marrow-derived macrophages, leads to the development of pathological cardiac remodeling. Inflammatory leukocytes release extracel...
Abstract 4369688: Efficacy and Safety of Nifedipine Compared to Intravenous Hydralazine for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Severe maternal hypertension is linked to adverse perinatal outcomes. Both nifedipine and hydralazine are commonly used antihypertensive agents in this setting....
Abstract 4357419: Multidomain Risk Profiles and Disease Progression Across Atherosclerotic Vascular Beds
Background: Atherosclerotic cardiovascular disease (ASCVD) manifests variably across coronary (CAD), cerebrovascular (CVD), and peripheral artery (PAD) beds. The contributions of s...
Abstract 4369799: AI-enhanced ECG for diastolic dysfunction: development, validation and prognosis across five international cohorts
Background: Evaluation of left ventricular diastolic function is integral to diagnosing heart failure with preserved ejection fraction (HFpEF), but echocardiography is resource-int...
Abstract 4362788: Brash Syndrome Requiring Permanent Pacemaker: A Case Report
Introduction: Bradycardia, Renal failure, Atrioventricular (AV) nodal blockade, Shock, and Hyperkalemia (BRASH) syndrome is a rare reversible clinical condition that can be life-th...
Abstract 4372993: Regural Physical Activity is Associated with High Exercise Performance in ACHD Patients
Background: Exercise tolerance is known to be decreased in adults with congenital heart disease (ACHD), and this is associated with prognosis. While regular physical activity is es...
Abstract 4362807: Tissue-engineered Patches loaded with Human Induced Pluripotent Stem Cell-derived Cardiac Cells Improve Cardiac Repair in Porcine Ischemic Cardiomyopathy
Introduction: Advances in material science and cell technology offer new possibilities in myocardial repair. Epicardial biocompatible scaffolds loaded with human (h)iPSC-derived ca...
Abstract 4343474: Inhibition of Satellite Glial Cell Activation in Stellate Ganglia Prevents Ventricular Arrhythmogenesis and Remodeling Following Myocardial Infarction
Background: Hyperactivity of sympathetic neurons in the stellate ganglia (SG) contributes to ventricular arrhythmias (VAs) and remodeling post-myocardial infarction (MI). However,...
Abstract 4366498: Intravenous Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency: A Meta-analysis with Trial Sequential Analysis
Background: Iron deficiency (ID) is common among patients with heart failure (HF), and it is associated with poor functional outcomes, increased hospitalizations, and higher mortal...
Abstract 4352496: The Role of Early Ezetimibe Combination with Atorvastatin in Patients with Atherosclerotic Cardiovascular Disease
Introduction: One third of patients with high and very high-risk of dyslipidemia reach their low-density lipoprotein cholesterol (LDL-C) targets (<55 mg/dL). Contemporary guidel...
Abstract 4343038: Effects of cardiac rehabilitation on body composition changes in patients receiving GLP-1 receptor agonists
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been shown to reduce weight. However, the degree to which this involves loss of fat and/or lean muscle mass...
Abstract 4365240: Plasma Levels of Per- and Polyfluoroalkyl Substances Are Associated with Accelerated Progression of Subclinical Atherosclerosis in Postmenopausal Women
Background: Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to increased atherosclerosis. However, longitudinal studies are limited, particularly in postmeno...
Abstract 4362916: Performance of the PREVENT CVD risk prediction score in breast cancer survivors
Background: Breast cancer survivors face an increased risk of cardiovascular disease (CVD) due to shared risk factors and cardiotoxic treatments such as anthracyclines and trastuzu...
Abstract 4372102: Bempedoic Acid Lowers LDL-C and Reduces Risk of Major Cardiovascular Events in Hypercholesterolemia: Meta-Analysis of 13 Randomized Controlled Trials
Introduction: Hypercholesterolemia drives atherosclerotic cardiovascular disease. Bempedoic acid (BA) lowers low-density-lipoprotein cholesterol (LDL-C) by inhibiting ATP-citrate-l...
Abstract 4371458: Determining the Impact of Long-term Ventricular Assist Device Use Prior to Heart Transplantation in Adolescents and Young Adults
Background: Ventricular assist devices (VADs) are pivotal in advanced heart-failure care for adolescents and young adults (AYA), serving primarily as bridges to heart transplantati...
Abstract 4344965: ST-Elevation Myocardial Infarction (STEMI) and Rhabdomyolysis: Analyzing In-Hospital Outcomes using the National Inpatient Sample
Introduction: Rhabdomyolysis is reported in approximately 25,000 cases annually in the United States. The demographic characteristics, clinical outcomes, and health care utilizatio...
Abstract 4357946: Baseline Prevalence and Patterns of Dementia in Older Adults Referred for Coronary Revascularization after an Acute Coronary Syndrome: A Multicenter Study from an Integrated Healthcare System
Background: Dementia and coronary artery disease (CAD) frequently coexist in older adults, complicating acute coronary syndrome (ACS) management. The prevalence of dementia among p...
Abstract 4371670: Higher Post-Ablation Scar Shifts Recurrence Towards Flutter
Background: Atrial arrhythmia recurrence remains a common challenge after catheter ablation. While both atrial fibrillation (AF) and atrial flutter (AFL) may recur, the relationshi...