Circulation
Articles in this Issue
Abstract Sun404: Physiologic Transgressions during Post-Cardiac Arrest Care as a Quality Metric
Introduction: High quality of post-cardiac arrest care has been linked to improved outcomes, but data is limited on compliance with current best practices. As part of the ICECAP (I...
Abstract 4367976: Aortic Tortuosity Predicts Conduction Disturbances After TAVR via Aortic Angle and Membranous Septum Length: A Structural Equation Modeling Approach
Background: Transcatheter aortic valve replacement (TAVR) has broadened treatment options for elderly patients with severe aortic valve stenosis (AVS), including those with challen...
Abstract 4365800: Longitudinal Associations of Dual-Energy Xray Absorptiometry-measured Total Body Fat Mass and Trunk Fat Mass with Cardiac Changes in 1803 Adolescents - A 7-year Mediation Study
Background: Adolescence has been identified as a critical time point when physiological adaptations deviate into pathological cardiometabolic disease processes. Large-scale prospec...
Abstract 4361736: Sex Differences in the Association between Vascular Endothelial Growth Factor D and Mortality in Patients With Suspected or Known Coronary Artery Disease: The ANOX Study
Background: Vascular endothelial growth factor D (VEGF-D) is a secreted glycoprotein that can promote lymphangiogenesis and angiogenesis. We previously demonstrated that serum leve...
Abstract 4360332: Impact of adherence to the global algorithm for initial crossing strategy selection in chronic total occlusion percutaneous coronary intervention
Background: The effect of selecting the initial crossing strategy using the global chronic total occlusion (CTO) crossing algorithm on the outcomes of CTO percutaneous coronary int...
Abstract 4351517: Desensitization of the Cardiac Troponin Complex by TnI Phosphorylation and Epigallocatechin-3-gallate
Introduction: The objective of this research is to experimentally demonstrate desensitization of thin filaments to Ca 2+ due to troponin I (...
Abstract 4373309: Chronic Electronic Cigarette Exposure Promotes Atherosclerosis and Chondrogenic Modulation of Smooth Muscle Cells
Introduction: Electronic cigarette use has emerged as a significant public health concern, particularly among adolescents and young adults. Epidemiological and experimental studies...
Abstract 4358869: Mitral Repair Versus Mechanical Replacement in Rheumatic Patients Under 65: Outcomes in the Era of The Whole-Life Cycle for Valvular Heart Disease
Background: Rheumatic mitral valve disease remains one of the most prevalent cardiovascular diseases in developing countries, affecting younger patients compared to degenerative va...
Abstract 4373113: Navigating the Uncharted Waters of Granulomatosis Polyangiitis - A Rare Case of Systemic Sequelae Leading to Organ Transplant in a Young Male
Systemic Granulomatous polyangiitis (GPA) can extend to rare organ involvement, including the heart which pose significant diagnostic and therapeutic challenges. A 26-year-old male w...
Abstract 4368384: Elevated Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Risk in Higher versus Lower Risk Individuals: Findings from the ARIC Study
Background: Lipoprotein(a) [Lp(a)] is a known risk factor for atherosclerotic cardiovascular disease (ASCVD). However, it is unclear whether the ASCVD risk associated with elevated...
Abstract 4363047: Cardiovascular Health among Bangladeshi, Pakistani, and Indian-origin participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Background: People of South Asian origin are the fastest-growing immigrant population in the United States (US) and experience excess cardiovascular disease (CVD) risk. However, da...
Abstract 4366096: Eicosapentaenoic Acid Attenuates Oxidation of Lp(a) and other Atherogenic Lipoproteins by a Potential Scavenging Mechanism
Background: Lipoprotein(a) (Lp(a)) is an ApoB-containing particle, and the primary carrier of oxidized phospholipid linked to increased cardiovascular (CV) risk. The oxPL may induc...
Abstract 4367730: Trends and Disparities in Stroke and Infective Endocarditis-Related Mortality in the United States, 1999–2019: A Nationwide Analysis
Background: Patients with infective endocarditis (IE) face an elevated risk of stroke; however, national trends in mortality related to both stroke and IE remain poorly characteriz...
Abstract 4368647: Improving Center Performance Assessment in Congenital Heart Surgery Through Causal Inference Weighting Approaches
Background: Traditional congenital heart surgery quality assessments rely on indirect standardization via regression, which can be complicated by heterogeneity in case-mix, surgica...
Abstract 4347901: Prognostic Role of Circulatory T-Cadherin and CT Angiography in Coronary Artery Disease
Background: Coronary artery disease (CAD) remains a leading cause of myocardial infarction (MI) and mortality worldwide. Early detection of coronary obstruction is critical to impr...
Abstract 4368585: Effect of Allostatic Load on Prevalence of Atrial Fibrillation and Associated Stroke: Insights from the REGARDS Study
Introduction/Background: The development of atrial fibrillation (AF) is increasingly understood as a multifactorial process involving genetics, lifestyle habits, and catecholamine...
Abstract 4350396: The relationship between cardiovascular risk factors control and all-cause or cardiovascular mortality across different cardiovascular-kidney-metabolic syndrome stages: Insights from NHANES 2005-2018
Background: This study aimed to prospectively investigate the association between strict control of cardiovascular risk factors and all-cause or cardiovascular mortality across dif...
Abstract 4366552: Extracorporeal Cardiopulmonary Resuscitation for Refractory Ventricular Fibrillation Arrest in ST-Segment Elevation Myocardial Infarction: A Multidisciplinary Critical Care Success
Background: Refractory cardiac arrest secondary to STEMI carries a high risk of mortality, particularly when ROSC is transient or unsustainable. Early extracorporeal cardiopulmonar...
Abstract 4371051: Comparative Effectiveness and Safety of Left Atrial Appendage Occlusion Devices: A Comprehensive Systematic Review and Meta-Analysis
Background: Percutaneous left atrial appendage occlusion (LAAO) is increasingly utilized for stroke prevention in non-valvular atrial fibrillation (NVAF) patients with contraindica...
Abstract 4362750: Electrocardiogram-Based Artificial Intelligence to Improve the Efficiency of Atrial Fibrillation Screening: A VITAL-AF Trial Analysis
Background: Atrial fibrillation (AF) is common and highly morbid. AF screening may detect AF earlier and facilitate preventive measures (e.g., anticoagulation to prevent stroke). H...
Abstract 4343931: The Inflammasome and Fibroblast Transdifferentiation and Activation in Heart Failure with Reduced Ejection Fraction
Background: Heart failure with reduced ejection fraction (HFrEF) is often caused by a precedent myocardial infarction (MI). While exogenous inflammatory cascades are well recognize...
Abstract 4367802: Cardiac Rehabilitation In a Safety Net Population (CRISP): Functional Outcomes Assessed by 6-Minute Walk Test
Background: Cardiac rehabilitation (CR) is recommended for secondary prevention following a range of cardiovascular insults and is proven to improve functional status and mobility...
Abstract 4370696: Patients with Dementia admitted for Heart Failure Demonstrate Worse Clinical and Patient-centered Outcomes
Introduction/Background: The incidence of heart failure (HF) among patients with Alzheimer’s disease and related dementias (ADRD) is expected to increase due in part to shared risk...
Abstract 4368762: Exceptionally Early Tricuspid Bioprosthetic Valve Degeneration: Diagnostic Evaluation and Successful Transcatheter Valve-in-Valve Intervention
Introduction: Structural valve degeneration (SVD) of bioprosthetic tricuspid valves within six months of implantation is exceedingly rare and presents significant management challe...
Abstract 4368821: Impact of Cardiac Immune-Related Adverse Events on One-Year Survival in Patients Treated with Immune Checkpoint Inhibitors: A Multicenter Propensity-Matched Analysis
Background: Immune checkpoint inhibitors (ICIs) are central to modern cancer immunotherapy but may lead to cardiac immune-related adverse events (irAEs), including myocarditis, per...