Circulation
Articles in this Issue
Abstract 4369927: The serum and glucocorticoid regulated kinase 1 (SGK1) inhibitor THRV-1268 attenuates hallmarks of heart failure by reducing inflammation and fibrosis beyond sodium/glucose cotransporter 2 inhibition
Background: Heart failure (HF) remains a leading cause of morbidity and mortality despite current therapies. SGK1, a stress activated kinase, plays a key role in remodeling, fibros...
Abstract 4363534: Rural-Urban Disparities in Cardiovascular Mortality Among Chemotherapy-Treated Cancer Survivors: A SEER-Based Analysis
Background: Cardiovascular disease (CVD) is the leading non-cancer cause of mortality among cancer survivors, with rural populations facing systemic disparities in access to cardio...
Abstract 4364777: Management of a Clot in Transit in a Patient with a Patent Foramen Ovale
Background: The clinical presentation of patients with acute pulmonary embolism (PE) greatly varies and can range from incidental imaging findings in asymptomatic patients to sudde...
Abstract 4370122: Day versus Evening Hypertensive medication and risk of Cardiovascular Disease: A Meta-analysis of Randomized Controlled Trials
Background: Hypertension significantly contributes to cardiovascular disease. Emerging evidence suggests that evening antihypertensive dosing may better control nocturnal blood pre...
Abstract 4367738: Diagnostic Accuracy of a Novel 3-Lead ECG System compared to Standard 12-Lead ECG for Detection of Acute Ischemia
Background: Timely presentation of patients with ST-segment elevation myocardial infarction (STEMI) is critical for reducing mortality and improving clinical outcomes. Prehospital...
Abstract 4365591: The Overlapping Burden: Trends in Cerebrovascular Mortality with Underlying Alzheimer’s Disease in the United States; A nationwide analysis (1999-2023) using CDC Wonder and ARIMA approach
Introduction: Cerebrovascular Disease accounted for more than 5 million deaths in last two decades in the U.S. population. The combined impact of cerebrovascular disease and Alzhei...
Abstract 4370264: Pharmacogenomic Analysis of CYP2D6 Variability and Metoprolol-Associated Adverse Drug Reactions in Hypertensive Patients Using FAERS Data
Background: Betablockers including Metoprolol are commonly used to treat hypertension but have adverse drug responses like bradycardia and hypotension. Genetic polymorphism in cyto...
Abstract 4367257: Biomarkers in Cardiac Arrest: An Analysis from the Critical Care Cardiology Trials Network
Background: Current clinical tools and biomarkers have limited predictive performance for neurological outcomes after cardiac arrest. Novel biomarkers, including kynureninase (KYNU...
Abstract 4337394: Impact of Severe Obstructive Sleep Apnea in Patients Undergoing Acute Type A Aortic Dissection Repair
BACKGROUND: Obstructive sleep apnea (OSA) is a prevalent comorbidity strongly associated with cardiovascular diseases, particularly in patients with aortic dissection (AD). However...
Abstract 4357633: Coronary Autoregulation Requires Arachidonic Acid and GPR39
Background: The molecular basis of coronary autoregulation is unknown. Based on our large animal data and previous reports by others, we hypothesized that arachidonic acid (AA) is...
Abstract 4373631: Predictors of Tafamidis treatment response in patients with wild-type transthyretin cardiac amyloidosis
Background: Tafamidis has been shown to improve outcomes in patients with transthyretin cardiac amyloidosis (ATTR-CM). However, 41% of patients experience clinical deterioration de...
Abstract 4370368: AI-Predicted Osteoporosis from Preprocedural CT Scans Predicts Mortality After TAVR: A Multicenter Study
Background: Osteoporosis and sarcopenia are common but underrecognized contributors to frailty in older adults undergoing transcatheter aortic valve replacement (TAVR). Standard ri...
Abstract 4365908: A Novel Composite Artificial Intelligence-Electrocardiography Risk Score Is Independently Associated with Mortality in Chronic Tricuspid Regurgitation
Background: Tricuspid regurgitation (TR) is associated with significant morbidity, but individualized treatment and timing of intervention are yet to be defined. We previously prop...
Abstract 4364752: Presumed POTS, proven otherwise: diagnostic value of autonomic testing
Background: Postural Orthostatic Tachycardia Syndrome (POTS) is characterized by exaggerated heart rate increase upon standing, often accompanied by disabling symptoms such as palp...
Abstract 4368476: Total Support by a Trans-Aortic Valve Micro-Axial Flow Pump Reduces Coronary Blood Flow in Both Normal and Post-reperfusion Coronary Arteries in a Goat Model of Ischemia-Reperfusion
Introduction: In cases of cardiogenic shock, the transaortic micro-axial flow pump (Impella) improves systemic circulation and increases coronary perfusion pressure (CPP) while red...
Abstract 4358519: Combination Therapy with SGLT2 Inhibitors and Tafamidis Improves Outcomes More Than Tafamidis Alone in ATTR Cardiac Amyloidosis
Background: Among cardiac amyloidosis subtypes, transthyretin cardiac amyloidosis (ATTR) has gained increased recognition with the development of disease-specific therapies. Tafami...
Abstract 4347763: Comparative Performance of an Artificial Intelligence-driven Electrocardiography Score with Traditional Risk Stratification Tools for Perioperative Risk Assessment in Non-cardiac Surgery
Background: The role of electrocardiography (ECG) has been limited in the preoperative risk evaluation in noncardiac surgery due to its low prognostic value. Recent advances in art...
Abstract 4339213: Association of Chronic Kidney Disease with Incident Probable Dementia and Cognitive Impairment in the SPRINT trial
Background: Emerging evidence links chronic kidney disease (CKD) to an elevated risk of dementia and cognitive impairment, but the strength of this association in patients with hyp...
Abstract 4360422: Evaluation of Retinal Ischemic Perivascular Lesions as a Potential Biomarker for Cardiovascular Disease Risk- A Systematic Review and Meta-Analysis
Introduction: Cardiovascular disease (CVD) is a leading global cause of mortality, often remaining undiagnosed until critical events occur. Retinal ischemic perivascular lesions (R...
Abstract 4362172: Prognostic Value of <sup>18</sup> F-fluorodeoxyglucose Positron Emission Tomography One Month After Initiation of Prednisolone Therapy in Patients with Cardiac Sarcoidosis
Background: 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is valuable for the diagnosis of cardiac sarcoidosis (CS). Although current guideline...
Abstract 4373220: Carotid Body Paraganglioma Causing Arterial Splaying: A Case Report and Surgical Management of a Vascular Neck Mass
Background: Carotid body tumors (CBTs), or paragangliomas, are rare, highly vascular neuroendocrine neoplasms arising at the carotid bifurcation. Though generally benign and slow-g...
Abstract 4370407: Impact of Donor and Recipient Risk Matching on Survival After Pediatric Heart Transplantation
Background: Pediatric heart transplantation (HT) is limited by donor numbers and graft quality, although recipient clinical acuity may have the greatest impact on post-HT survival....
Abstract 4365569: GLP-1 Receptor Agonists and Cardiovascular Outcomes in Patients with Type 2 Diabetes Undergoing TAVI: A Real-World Cohort Study
Introduction: In patients with type 2 diabetes (T2D) at high cardiovascular risk, glucagon-like peptide-1 receptor agonists (GLP1-RAs) have been shown to reduce major adverse cardi...
Abstract 4362685: Utilizing Telemedicine to Promote Equitable Care for Higher Risk Orthotopic Heart Transplant Recipients: A Single Center Analysis
Introduction: Orthotopic heart transplantation (OHT) is the definitive treatment in patients with advanced heart failure. The medical and psychosocial complexity of OHT requires mu...
Abstract 4361998: Global Burden of Ischemic Heart Disease Attributable to High Fasting Glucose: Epidemiologic Trends and Forecasts to 2050
Background: Ischemic heart disease (IHD) remains a leading global cause of mortality and disability. High fasting blood glucose (FBG) is a significant modifiable risk factor contri...