Circulation
Articles in this Issue
Abstract 4341349: Improved Cardiac Sympathetic Tone Following Transcatheter Aortic Valve Implantation in Real-World Aortic Stenosis Patients
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has become an established treatment option in patients with severe AS, and the indication for the procedure has recently...
Abstract 4370295: Single dose of a novel CRISPR-CasX editor potently reduces triglycerides in preclinical models and efficiently edits <i>APOC3</i> in non-human primates
Background: Severe hypertriglyceridemia (SHTG) and familial chylomicronemia syndrome (FCS) are marked by extreme triglyceride (TG) elevations, raising the risk for acute pancreatit...
Abstract 4370646: Breaking New Ground: Prognostic Value of Autonomic Dysfunction in Cardiac Amyloidosis
Background: Cardiac amyloidosis (CA) is a progressive condition in which abnormal amyloid proteins build up in the heart, leading to serious health issues and high mortality. Many...
Abstract 4367116: Renal Artery Denervation in Patients with Resistant Hypertension: A systematic review and meta-Analysis
Background: Resistant hypertension (RH), defined as uncontrolled blood pressure (BP) despite ≥3 antihypertensive agents at maximally tolerated doses, remains a significant therapeu...
Abstract 4362255: Increased Prevalence of High Lipoprotein(a) in Autoimmune or Inflammatory Diseases: A Multi-Center Cohort Study
Introduction: Lipoprotein(a) [Lp(a)] and autoimmune or inflammatory diseases (AIIDs) are both independently associated with CVD. Systemic inflammation may increase Lp(a) levels thr...
Abstract 4359831: Overweight, Obesity, and Poor Nutrition Drive Persistent Sex Disparities in Ischemic Heart Disease Across U.S. States.
Background: Previous research has evaluated sex differences in ischemic heart disease (IHD) outcomes in the United States, but state-level disparities remain underexplored....
Abstract Sat204: Prediction of Common Carotid Flow using Pressure Values in a Swine Model of CPR
Introduction: The primary goals of cardiopulmonary resuscitation (CPR) are to generate adequate myocardial blood flow to enable restoration of mechanical function and adequate brai...
Abstract 4347146: One-Stop Hybrid TAVR, Off-Pump CABG, and Ascending Aortic Wrapping in a High-Risk Patient: A Case Report
Background: Surgical correction of ascending aortic aneurysm in conjunction with severe aortic stenosis and complex coronary artery disease carries substantial operative risk, part...
Abstract 4368358: Practice variation in cardiovascular computed tomography (CCT) imaging protocol and utility of tracheal area ratio in airway assessment in pediatric patients with vascular ring (VR)- a multicenter study
Intro: Vascular rings (VR) are congenital anomalies where the trachea and esophagus are encircled by vascular structures and may require surgery. There are no published studies on...
Abstract 4366316: Sarcoplasmic Reticulum Ca <sup>2+</sup> Leak Drives Arrhythmogenesis During In Vivo Maturation of Stem Cell-Derived Cardiomyocytes
Heart regeneration via transplantation of human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CMs) holds significant clinical potential. However, a transient, yet severe, period of ventri...
Abstract 4360679: Increased Carnitine Palmitoyltransferase 1a Expression is a Critical Cardioprotective Response to Pathological Stress That Suppresses Gene Programs For Adverse Remodeling Through Non-Conical Signaling and Enables Rescue by Gene Delivery
Background: Carnitine palmitoyl transferase 1 (CPT1) is a rate-limiting enzyme for long chain fatty acid oxidation (FAO). In adult hearts, CPT1b predominates, while CPT1a is co-exp...
Abstract 4372200: Digital Health Intervention Using Prospective Symptom Monitoring With Data Visualization Improves Self-care in Adults With Recent Acute Coronary Syndrome
Background: Acute Coronary Syndrome (ACS) survivors often experience angina and recurrent ACS post-hospitalization. These events are potentially preventable if patients report recu...
Abstract 4366012: Advanced Heart Failure and Mechanical Circulatory Support in the Context of Incarceration: A Clinical Challenge
Introduction: Advanced heart failure in incarcerated individuals presents unique clinical, ethical, and logistical challenges. Mechanical circulatory support (MCS), including left...
Abstract 4362985: Waitlist Outcomes in Patients on VA-ECMO With and Without Left Ventricular Unloading as a Bridge to Heart Transplantation
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to bridge patients to heart transplantation following the 2018 UNOS heart allocation pol...
Abstract 4361996: Prevalence of Cardiovascular-Kidney-Metabolic Syndrome and Association with Target Organ Injury in Youth with Hypertension Disorders Who Have Congenital Heart Disease: A SUPERHERO Analysis
Introduction/Background: Cardiovascular-kidney-metabolic (CKM) syndrome is the interplay between metabolic risk factors such as obesity and diabetes, chronic kidney disease (CKD),...
Abstract 4342359: Comprehensive Plasma Proteomics Profiling Identifies Circulating Biomarkers to Predict Both All-cause Mortality and Disease Progression in Patients with Transthyretin Amyloid Cardiomyopathy
Background: Despite the development of disease-modifying therapy (DMT) for patients with transthyretin amyloid cardiomyopathy (ATTR-CM), the rates of mortality and disease progress...
Abstract 4361746: Jugular Approach for Leadless Pacemaker Implant: A Single-Arm Meta-Analysis of Efficacy and Safety Across Adult and Pediatric Populations
Background: Leadless pacemaker therapy has emerged as a transformative alternative to conventional transvenous systems, mitigating lead- and pocket-related complications. While the...
Abstract 4369743: Proof-of-Concept Viral Transduction in Human Living Myocardial Slices: Advancing Human Pre-Clinical Models for Cardiac Gene Therapy
Background: Cardiac gene therapy holds the potential to transform the treatment of inherited and acquired cardiovascular diseases by correcting the causative basis of disease. Howe...
Abstract 4369293: Clinical outcomes associated with utilization of Glucagon-like Peptide-1 Receptor Agonists in heart failure patients in the United States
Background: Current evidence recommends glucagon-like peptide-1 receptor agonists (GLP-1 RA) utilization in type 2 diabetes or obesity with cardiovascular diseases. However, GLP-1...
Abstract 4363589: Neighborhood-Level Gentrification and Rates of ST-Elevation Myocardial Infarction
Background: Despite advances in preventive cardiology, there remain differences in ST Elevation Myocardial Infarction (STEMI) rates among certain populations and across neighborhoo...
Abstract 4365448: The Effects of Resistant Starch Supplementation on Human Gut Microbiota Cholesterol Metabolism
Resistant starch (RS), a major category of dietary fiber, promotes healthy lipid and glucose metabolism. These effects are partly mediated by gut microbes. RS is known to influence microbial bile acid...
Abstract 4362221: Association of High-Density Lipoprotein Cholesterol in Middle-Aged Adults and Development of Heart Failure with Preserved Ejection Fraction Later in Life
Background: Heart failure with preserved ejection fraction (HFpEF) represents over half of all heart failure cases and is projected to rise with the aging population. High-density...
Abstract 4372843: Cognitive Impairment in Heart Failure: A Systematic Review and Meta-Analysis of Prevalence and Predictors
Background: Cognitive impairment (CI) is increasingly recognized as a critical comorbidity in patients with heart failure (HF), contributing to medication nonadherence, readmission...
Abstract 4363148: Polygenic Modification of Weight Loss Response to GLP-1 Receptor Agonists
Background: GLP-1 receptor agonists (GLP-1 RAs) effectively treat obesity, yet weight loss varies among individuals. Polygenic risk scores (PRS) summarize genetic susceptibility to...
Abstract 4361461: Transthoracic Echocardiographic and AI-ECG Predictors of Atrial Arrhythmia Recurrence After Surgical Ablation
Background: Atrial arrhythmia recurrence after surgical ablation remains challenging to predict and integrating novel biomarkers may improve risk stratification....