Circulation
Articles in this Issue
Abstract 4364820: Impact of GLP-1 Agonists on Cardiovascular Outcomes in Patients with Heart failure with Preserved Ejection Fraction: Analysis of Real-world studies
Background: Patients with heart failure with preserved ejection fraction (HFpEF) have an increased risk of cardiovascular events. Glucagon-like peptide-1 receptor agonists (GLP-1RA...
Abstract 4366137: Multimodal AI Signatures of Cardiac Remodeling Independently Predict Worse Aortic Stenosis Prognosis
Introduction: Aortic stenosis (AS) follows a progressive course, with delays in diagnosis linked to worse outcomes. Traditional AS categorization relies on functional Doppler param...
Abstract 4368690: Impact of Glycemic Control and Treatment in Maternal Diabetes on Congenital Heart Defects in Infants
Background: Diabetes during pregnancy is a major risk factor for congenital heart disease (CHD), particularly septal defects and ventricular hypertrophy. Hemoglobin A1c (HbA1c) and...
Abstract 4364644: Contemporary Management and Outcomes of Newly Diagnosed Chronic Limb Threatening Ischemia in the Veterans Affairs Health Care System
Introduction: Chronic limb threatening ischemia (CLTI) is associated with high risks of amputation and mortality. The purpose of this study was to investigate the patterns of manag...
Abstract 4367320: <u>Predictive utility of effective regurgitation orifice area to left ventricular end diastolic volume ratio in MitraClip treatment: Outcomes from a multi-center study.</u>
Introduction: MitraClip (MC) placement for transcatheter edge-to-edge repair (TEER) is being increasingly utilized for treatment of secondary mitral regurgitation (SMR). The aim of...
Abstract 4373642: Efficacy of GLP-1 Receptor Agonists in Patients with Established Cardiovascular Disease: A Meta-Analysis of Nine Randomized controlled trials
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2...
Abstract 4369832: The Impact of COVID-19 pandemic on Mortality and Place of Death among Patients with Ischemic Heart Disease in the United States (2018–2023): A nationwide analysis
Background: The COVID-19 pandemic disrupted health care systems and emergency care access across the United States. Research Question: What was...
Abstract 4340954: Self-Amplifying RNA Enhances Cardiac Protein Expression and Functional Recovery in a Myocardial Infarction-Induced Heart Failure Murine Model
Introduction: Messenger RNA (mRNA) technology has the potential to revolutionize current therapeutic strategies for heart failure. However, mRNA-based therapies require high dosing...
Abstract 4359422: Low-Dose GLP-1 Receptor Agonist Therapy Exerts Anti-Fibrotic Effects Across Multiple Organs in Cardiometabolic HFpEF
Background: HFpEF accounts for over 50% of heart failure cases and has limited treatment options. A central feature of HFpEF is myocardial fibrosis, which is correlated with diasto...
Abstract 4371142: Diabetes Status and Cardiovascular Disease in U.S. Adults: Insights from NHANES 2021–2022
Background: The cardiovascular impact of diabetes and prediabetes, especially in the context of behavioral risk factors and comorbidities, remains an urgent public health issue. We...
Abstract Sat701: Prolonged In-Hospital CPR in Pediatric OHCA Patients with Estimated Poor Neurological Prognosis: Challenges in Termination Resuscitation in Children
Introduction: Pediatric out-of-hospital cardiac arrest (OHCA) patients often present with a poor predicted neurological prognosis. While prolonged cardiopulmonary resuscitation (CP...
Abstract 4359454: Low-Dose Semaglutide Attenuates Cardiac Lipid Content and Hepatic Steatosis in Cardiometabolic HFpEF: Weight Loss Independent Actions of GLP-1 Receptor Activation
Background: Heart failure with preserved ejection fraction (HFpEF) is a complex, multisystemic disorder associated with cardiometabolic comorbidities and significant mortality. Abe...
Abstract 4363689: QT Interval Prolongation Is Independently Associated With Hypermagnesemia: Insights From A Single-Center Observational Study
Introduction: Ventricular arrhythmias and sudden cardiac death are among the leading causes of mortality in patients with chronic kidney disease (CKD). This risk arises from shared...
Abstract 4366685: Impact of Frailty on outcomes after transcatheter-edge-to-edge repair (TEER) in patients with mitral regurgitation (MR)
Introduction: Transcatheter-edge-to-edge repair (TEER) has emerged as a minimally invasive option for patients with significant mitral regurgitation and high surgical risk. While f...
Abstract 4367497: Comparison of Risk Factors in South Asian and White Patients Before and After Percutaneous Coronary Intervention
Background: Prior studies have demonstrated that South Asian (SA) patients experience a disproportionately higher burden of coronary artery disease compared to other ethnic groups,...
Abstract 4366957: Predicting Non-Zero Coronary Artery Calcium Score in Middle-Aged Population: Comparing an Artificial Intelligence-based Model with Existing ASCVD Risk Scores in the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: A positive coronary artery calcium (CAC) scan (Agatston score >0) establishes the presence of subclinical coronary artery disease. Currently, atherosclerotic cardiov...
Abstract 4365874: Left Pulmonary vein thrombosis following Lobectomy in a patient with Atrial fibrillation: a unique contraindication to cardioversion
Case presentation: 82-year-old male who presented with symptoms of progressively worsening shortness of breath and palpitations for 4 days. He was recently diagnosed with non-small...
Abstract 4368391: Heart Failure demographic and geographical trends over the past decade
Background: Heart failure is a growing public health concern in the United States, with a steadily increasing prevalence. It affects approximately 1.9% to 2.6% of adults overall an...
Abstract Or111: Using mixed methods to refine a resilience intervention for cardiac arrest survivors and their caregivers, <i>Recovering Together after Cardiac Arrest</i>
Background: Emotional distress is common in cardiac arrest (CA) survivors and their family caregivers and undermines long-term health and quality of life. To address this problem,...
Abstract 4372797: Saline vs. Contrast Optical Coherence Tomography—A Prospective Multicenter Trial
Background: Frequency-domain Optical Coherence Tomography (FD-OCT) is increasingly used for intravascular imaging and optimizing percutaneous coronary interventions. Conventional O...
Abstract 4365987: Real-World Outcomes of Mavacamten Monotherapy in Obstructive Hypertrophic Cardiomyopathy: Symptomatic and Hemodynamic Improvements Without Increased Adverse Events
Background: MARVEL-HCM is a US multicenter study assessing the safety and effectiveness of mavacamten in real-world academic and community practices. Mavacamten is a first-in-class...
Abstract 4367314: The Use of Common Cardiovascular Medications Is Associated With a Comparable Decreased Relative CVD Risk in Cancer Survivors and non-Cancer Patients
Introduction: The frequent coexistence of cardiovascular disease (CVD) and cancer, including due to shared risk factors, necessitates understanding the benefit of medications in CV...
Abstract 4365761: Acoramidis Lowers NT-proBNP in a Larger Proportion of ATTRibute-CM Study Participants With Transthyretin Amyloid Cardiomyopathy Compared with Placebo, Independent of Atrial Fibrillation Status
Background: Atrial fibrillation/flutter (AF/AFL) is a frequent complication of heart failure in transthyretin amyloid cardiomyopathy (ATTR-CM) and its increasing incidence is a mar...
Abstract 4364177: Underutilization of Palliative Care in Peripheral Artery Disease: A State-of-the-Art Review Across Cardiovascular Conditions
Introduction: Peripheral artery disease (PAD) is associated with high morbidity and mortality, yet palliative care (PC), a supportive, team-based approach integrated remains underu...
Abstract 4358715: Racial and Insurance Disparities in Left Atrial Appendage Occlusion Referrals Among Atrial Fibrillation Patients: A National Inpatient Sample Study (2018–2023)
Background: Left Atrial Appendage Occlusion (LAAO) is a critical intervention for stroke prevention in patients with atrial fibrillation who are unsuitable for long-term anticoagul...