Circulation
Articles in this Issue
Abstract 4343454: Initial Total Correction vs. Staged Repair in Neonatal TOF: Nationwide Evidence on Multi-Organ Outcomes
Background: While early surgical repair in tetralogy of Fallot (TOF) is increasingly favored, the long-term impact of surgical strategy—particularly on extracardiac organs—remains...
Abstract 4368638: Comparable One-Year Efficacy and Safety of Spironolactone Versus Amiloride in Resistant Hypertension: A Retrospective Cohort Analysis
Background: Spironolactone is frequently used as the fourth-line agent for resistant hypertension, but concerns over hyperkalemia have prompted some clinicians to use amiloride des...
Abstract 4362814: The effect of a BMPR2 mutation on cardiac mechanotransduction
Background: Pulmonary arterial hypertension (PAH) is a rare disease that originates in the lungs and patients eventually die of right heart failure. A mutation in the Bone Morphoge...
Abstract 4366572: Impact of Type 2 Myocardial Infarction in Diabetic Ketoacidosis: Insights from a National Cohort
Background: Diabetic ketoacidosis (DKA) generates profound metabolic derangements that can lead to myocardial oxygen supply-demand imbalance, predisposing patients to Type 2 myocar...
Abstract 4366161: Performance of Multimodal LLMs in ECG Interpretation: A Comparative Analysis of ChatGPT and Google Gemini for ECG Diagnosis
Background: Multimodal Large Language Models (LLMs) such as ChatGPT (4o mini) and Gemini (2.5 Flash) have shown proficiency in textual tasks, yet their performance in ECG image int...
Abstract 4369991: Small molecule inhibitors of serum glucocorticoid kinase 1 (SGK1) prevent cardiac structural and functional decline induced in a transverse aortic constriction (TAC) model
Introduction: Heart failure with reduced ejection fraction (HFrEF) remains a leading cause of morbidity and mortality despite current therapies. The transverse aortic constriction...
Abstract 4366194: Association Between Exposure to Toxic Release Inventory Facilities and Hypertrophic Cardiomyopathy Prevalence in Maryland
Introduction: Hypertrophic cardiomyopathy (HCM) is regarded as a monogenic cardiovascular disease; however, 70% of HCM patients do not harbor a pathogenetic variant. This observati...
Abstract 4366834: Angiography-based pulmonary capillary transit time is a promising diagnostic tool for single ventricle pulmonary arteriovenous malformations
Background: Pulmonary arteriovenous malformations (PAVMs) are a universal complication in single ventricle heart disease, but the tools to assess them are limited. In this study, w...
Abstract 4363276: Efficacy of Anti-inflammatory Therapies for Pericarditis: A Systematic Review and Network Meta-analysis
Background: One of the most troublesome complications of acute pericarditis is recurrence. Non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine form the cornerstone treatm...
Abstract 4371384: Twenty-Five-Year Trends in Stroke-Related Mortality Among Chronic Kidney Disease Patients in the United States: A Nationwide Analysis Using CDC WONDER (1999–2023)
Background: Globally, more than 350 million people are affected by chronic kidney disease (CKD), a sinister condition associated with poor cerebrovascular outcomes, such as stroke....
Abstract 4373532: Small increases in temperature may increase mortality attributed to ST elevation myocardial infarction in tropical regions: A case-crossover analysis from Brazil.
Background: Prior literature has demonstrated that temperature variation is associated with overall cardiovascular mortality. However, while extreme cold temperature are associated...
Abstract 4365493: Lactate dehydrogenase and clinical outcomes in patients with heart failure and reduced ejection fraction: Insights from the GALACTIC-HF trial
Background: Lactate dehydrogenase (LDH) is a cytoplasmic enzyme found in most cells that catalyses the forward and backwards conversion of pyruvate to lactate. Tissue LDH concentra...
Abstract Sat604: Mean age at Out-of-Hospital Cardiac Arrest: National trends
Background: While a decrease in mean age has been reported in out-of-hospital cardiac arrest (OHCA) cases regionally in Chicago, it is not known if similar trends are observed nati...
Abstract 4371310: Impact of Frailty on In-Hospital Outcomes for Patients Admitted for Hypertensive Emergency in the United States
Background: Hypertensive emergency (HE) is a life-threatening condition that poses a significant risk for increased morbidity and mortality. It is not known with certainty how a st...
Abstract 4363582: A Rare Case of Genetic Cardiomyopathy: SCN5A mutation-associated Multifocal Ectopic Premature Purkinje-related Complexes Syndrome with Heart Failure with Improved Ejection Fraction
Introduction: Inherited cardiomyopathies and channelopathies can be clinically challenging to diagnose and manage. SCN5A mutation-associated Multifocal Ectopic Premature Purkinje-r...
Abstract 4369695: Unsupervised Clustering of Nocturnal Heart Rate Variability Reveals Autonomic Subtypes in Dementia Caregivers
Background: Dementia caregivers face elevated cardiovascular risk due to chronic stress and poor sleep. Nocturnal RMSSD, a time-domain HRV measure of parasympathetic activity, offe...
Abstract 4345711: Mandatory Use of the Least Expensive ACEis and ARBs Would Generate Significant Cost Savings Within Medicare Part D
Introduction: Serving more than 50 million beneficiaries, Medicare Part D has a responsibility to balance broad prescription drug coverage with fiscal sustainability. We provide an...
Abstract 4363050: From Diagnosis to Timely Care: How Social Determinants of Health Affect Pediatric Patients with Wolff-Parkinson-White Syndrome
Background: Social determinants of health (SDOH) contribute to disparities in cardiovascular care and outcomes. In pediatric Wolff-Parkinson-White (WPW) syndrome, timely access to...
Abstract 4344649: Heart Failure in the Hematologic Spectrum: Cardiovascular Toxicity and Targeted Therapy in Myelodysplasia with Ring Sideroblasts
Background: Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is defined by macrocytic anemia, ineffective erythropoiesis, and ≥15% ring sideroblasts, often linked to...
Abstract 4361025: Dietary Modifiers of Blood Metabolome Predict Risks of Incident Type 2 Diabetes and Coronary Heart Disease
Background: Diet is a major modulator of blood metabolites linked to the risk of type 2 diabetes (T2D) and coronary heart disease (CHD). However, no study has comprehensively asses...
Abstract 4368307: Impaired Myocardial Perfusion in Patients with Primary Mitral Regurgitation Due to Mitral Valve Prolapse
Background: Mitral valve prolapse (MVP) is frequently associated with mitral regurgitation (MR), which increases left ventricular (LV) preload and can lead to LV hypertrophy. In ot...
Abstract 4368735: Shifting Patterns in Essential Hypertension Mortality in the United States Before and After the COVID-19 Pandemic
Background: Essential hypertension is a leading modifiable risk factor for cardiovascular morbidity and mortality. The COVID-19 pandemic introduced major disruptions in chronic dis...
Abstract 4358458: Impact of daily experience of discrimination and microaggression on vascular function among Black women – Preliminary results from an ecological momentary assessment study
Introduction: Emerging evidence shows increased cardiovascular disease (CVD) risk in Black women of childbearing age (18-49 years), a critical window for CVD prevention. Racial dis...
Abstract 4368068: Is Earlier Better? Comparative Outcomes of Early Valve Replacement versus Conservative Management in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-analysis
Background: Aortic stenosis (AS) is the most common valvular heart disease, with a growing burden of patients presenting with severe yet asymptomatic disease. The US FDA recently a...
Abstract 4368319: Effects of Glucagon-Like Peptide-1 Receptor Agonists on Endothelial Function and Cardiometabolic Outcomes in Polycystic Ovary Syndrome: A Systematic Review
Background: Polycystic ovary syndrome (PCOS) is associated with early-onset cardiometabolic dysfunction, including insulin resistance and vascular impairment. Although glucagon-lik...