Circulation
Articles in this Issue
Abstract 4369875: The Association Between Cardiac Resynchronization Therapy and Survival in Patients with Cardiac Amyloidosis: A Multicenter Retrospective Study.
Background: Cardiac amyloidosis (CA) patients with reduced left ventricular ejection fraction (EF) are at increased risk for mortality. The benefit of cardiac resynchronization the...
Abstract 4362395: Efficacy of Mavacamten Combined with Standard Therapy in Hypertrophic Obstructive Cardiomyopathy: A Retrospective Cohort Study
Background: Hypertrophic obstructive cardiomyopathy (HOCM) is usually treated with standard therapy: beta-blockers (BBs) and/or non-dihydropyridine calcium channel blockers (CCBs)....
Abstract 4368937: Rationale and Design of A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: A Pediatric Heart Network (PHN) Study
Background: Adolescents with moderate and severe congenital heart disease (CHD) experience considerable risk of mental health comorbidities. Youth with CHD have 5-7 times greater o...
Abstract 4351459: Hemodynamic Dance: Navigating Physiological Shifts in Ventricular Septal Defects After Myocardial Infarction
Description of Case: A 73-year-old male with hypertension and hyperlipidemia presented with four weeks of progressive dyspnea. He was diagnosed with an anterior STEMI and underwent left heart catheter...
Abstract 4367146: Coronary Artery Calcium Scoring Accuracy in Iran: A Meta-Analysis and Systematic Review
Introduction/Background: Coronary artery Calcium Scoring (CACS) has been recognized as a risk predictor of major cardiovascular events in high income countries. However, more resea...
Abstract 4369751: Prognostic Value of Left Ventricular Global Longitudinal Strain in Patients With Preserved Ejection Fraction Undergoing Kidney Transplantation
Backround: Left ventricular ejection fraction (LVEF) is traditionally used for cardiac risk stratification but may miss subclinical myocardial dysfunction. Left ventricular global...
Abstract 4359418: The TGFβ-Whsc1 Axis Drives Macrophage to Myofibroblast Transition during Tissue Repair and Is Disrupted in Diabetic Wound Healing
Background: While macrophage to myofibroblast transition (MMT) has been reported in various tissues and diseases, it has not been studied in wound healing. We sought to identify th...
Abstract 4344415: Role of MST1 in the development of endothelial dysfunction
Introduction: The Hippo pathway is an intracellular pathway that negatively regulates cell survival. Experimental evidence demonstrated that the activation of mammalian sterile 20-...
Abstract 4368727: Characteristics and Prognosis of Non-Dilated Idiopathic Non-Ischemic Cardiomyopathy: A Distinct Clinical and Prognostic Entity
Backround: Idiopathic non-ischemic cardiomyopathy (iNICM) includes patients without identifiable causes of left ventricular systolic dysfunction. While dilated cardiomyopathy (DCM)...
Abstract 4357917: Evolving Trends in Post-Transplant Mortality from Heart and Lung Failure: Unexpected Plateaus and Persistent Inequities in the United States Population, 1999 to 2023
Background: Despite the therapeutic efficacy of heart (HTx) and lung transplantation (LTx) for end-stage organ disease, post-transplant complications remain leading contributors to...
Abstract 4367639: Interaction of Age, Peripheral Artery Disease, and In-hospital Outcomes Among Patients Undergoing Index Percutaneous Interventions
Introduction: Peripheral artery disease (PAD) is known risk factor for adverse cardiovascular outcomes as well as coronary artery disease. However, the interaction between PAD and...
Abstract 4359983: Externally Supported Acellular Tissue-Engineered Vessels Demonstrate Regeneration and Patency as Coronary Artery Bypass Grafts in Preclinical Models and Early Clinical Experience
Background: Coronary artery bypass grafting (CABG) remains the gold standard for severe coronary artery disease, but autologous vessel limitations including early saphenous vein gr...
Abstract 4363350: Long-Term Outcomes in Adults with Double Outlet Right Ventricle: A Multi-centred Cohort Study
Introduction: Double Outlet Right Ventricle (DORV) encompasses a heterogenous range of congenital heart diseases (CHD). While survival to adulthood has improved, the risk of long-t...
Abstract 4354018: The Joint Effects of Life’s Essential 8 and Genetics on Cognitive Impairment and Dementia Risk in People with Diabetes: Findings from the UK Biobank and All of Us
Background: Diabetes is associated with increased risks of cognitive dysfunction and dementia. Although genetic risk for dementia is often seen as deterministic, healthy lifestyles...
Abstract 4368768: Depression Severity is Associated Longitudinally with a Metabolic Profile Related to Psychological Distress and Cardiometabolic Risk
Introduction: Metabolic dysregulation is posited to underlie observed links between chronic distress and higher cardiometabolic disease risk. We recently identified a plasma metabo...
Abstract 4357922: Early Diagnosis of Double Heterozygous Familial Hypercholesterolemia Enables Effective Lipid-Lowering Therapy
Familial hypercholesterolemia is a genetic disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C), most commonly due to mutations in the LDLR or APOB genes. The hetero...
Abstract 4372594: Cholate clearance as assessed by HepQuant-SHUNT is predictive of clinical outcomes in individuals with Fontan circulation
Introduction: Fontan-associated liver disease [FALD] is universal in individuals with Fontan circulation [FC]. The dual cholate clearance test is a noninvasive, flow-dependent meas...
Abstract 4370014: Association of Inhaled Nitric Oxide with VA-ECMO Weaning and Short-Term Outcomes in ECPELLA Patients: A Retrospective Study
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) combined with the Impella left ventricular assist device (ECPELLA) has emerged as a promising strategy for c...
Abstract 4362992: Pulmonary arterial smooth muscle VPS34 activation is a shared molecular mechanism in adult pulmonary hypertension and congenital diaphragmatic hernia-associated pulmonary vascular remodeling
Introduction and Hypothesis: Congenital diaphragmatic hernia (CDH) is frequently associated with pulmonary hypertension (PH), characterized by pulmonary vascular remodeling, a lead...
Abstract 4360611: Ensembled AI Model Can Detect Carotid Artery Intraplaque Hemorrhage from CT Angiograph
Introduction: Carotid artery intraplaque hemorrhage (IPH) is increasingly recognized as a predictive marker of cerebrovascular events. Despite widespread utilization of contrast-en...
Abstract 4367837: <i>Trends of Diabetes Mellitus with Peripheral Circulatory Complications mortality in the United States (US), 1999-2020</i>
Background: Diabetes mellitus (DM) is a major public health concern in the United States, with peripheral circulatory complications significantly contributing to morbidity and mort...
Abstract 4371207: Impairments in Sleep and Physical Activity Are Comparable in CMD and Obstructive CAD and Independently Predict Angina Burden
Background: The impact of sleep quality and physical activity in coronary microvascular dysfunction (CMD) remains unclear [1, 2] with prior studies relying on self-reported measure...
Abstract 4365359: Ethnic disparities in the effectiveness of electronically delivered nudges to increase influenza vaccination uptake: A secondary analysis of the NUDGE-FLU-CHRONIC trial
Background: Persistent racial and ethnic disparities exist in influenza vaccination coverage. Increasing uptake in this population could potentially reduce influenza infection and...
Abstract 4373725: Statin Therapy and Incident Diabetes: Identifying Susceptible Populations
Introduction: Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death in the United States. Preventative treatment with cholesterol-lowering medications suc...
Abstract 4358112: Integrative Epigenomic and Single-Cell Transcriptomic Profiling of Thoracic Aortic Aneurysms
Introduction: Thoracic aortic aneurysms (TAAs) affect up to 1% of the population. Transcriptional regulation governs vascular smooth muscle cell (VSMC) phenotypic plasticity, yet u...