Circulation
Articles in this Issue
Abstract 4367388: V-REMi: A Novel Electro-Mechanical Index Highlights Trends Toward Superior Remodeling with Conduction System Pacing
Background: Cardiac resynchronization therapy (CRT) via conduction system pacing (CSP), particularly left bundle branch pacing (LBBP), offers a physiologic alternative to biventric...
Abstract 4366774: Liver Angiocrine Myeloid-Derived Growth Factor Protects Against Endothelial Dysfunction in Pulmonary Arterial Hypertension
Background: Circulating angiogenic growth factors have been implicated in the pathobiology of pulmonary arterial hypertension (PAH), yet their roles remain incompletely understood....
Abstract 4366197: Selnoflast reduces markers of systemic inflammation in participants with coronary artery disease and elevated C-reactive protein
Introduction: While low-density lipoprotein (LDL) cholesterol lowering is central to coronary artery disease (CAD) management, elevated interleukin-6 (IL-6) and high-sensitivity CR...
Abstract 4358758: Admission Acid-Base Status and Mortality in Cardiac Intensive Care Unit Patients
Background: Little is known about the epidemiology and prognostic significance of acid-base disturbances in the cardiovascular intensive care unit (CICU). This study examines the a...
Abstract 4361204: Temporal Trends in Cardiac Arrest and Cancer-Related Mortality Among Adults in the United States, 1999-2023
Background: Cardiac arrest (CA) remains a major contributor to cardiovascular-related mortality in the United States. The coexistence of cancer significantly exacerbates overall di...
Abstract 4370259: Medical Cannabis and Acute Myocardial Infarction Risk: A Case-Time-Control Analysis
Introduction/Background: Medical cannabis (MC) appears to have multiple effects on the cardiovascular system via sympathomimetic effects and parasympathetic effects, and there is c...
Abstract 4369967: Performance of Cardiovascular Risk Prediction Models in Cancer Survivors: A Systematic Review and Meta-Analysis
Background: Cancer survivors have a substantial risk of cardiovascular diseases (CVD) due to shared risk factors and cancer treatment-induced cardiac toxicity. However, the predict...
Abstract 4370053: Unique Insights into the Pathobiology of TNNI3 Cardiomyopathy using Novel Murine and Porcine Models of Disease
Background: Cardiac troponin I (cTnI, encoded by TNNI3 ) inhibits contraction by preventing actin-myosin interaction. Pathogenic...
Abstract 4367266: A Diagnostic Challenge: Wild-Type Transthyretin Cardiac Amyloidosis in a Patient With Systemic Lupus and Ischemic Cardiomyopathy
Background: Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive, infiltrative cardiomyopathy increasingly recognized in older adults. Despite improved awareness, and diagn...
Abstract 4361451: Prevalence and Outcomes of Antiphospholipid Antibodies in Patients with Peripheral Artery Disease
Background: Although antiphospholipid antibodies (aPL) are classically associated with excess risk of thrombosis in antiphospholipid syndrome (APS), emerging data suggest that aPLs...
Abstract 4369876: CT-Based Radiomics Offers Prognostic Insight in Cardiomyopathy Patients Undergoing ICD Implantation
Introduction: Intramyocardial fat and scar burden have been linked to mortality in cardiomyopathy (CM) patients. However, the prognostic value of advanced imaging features derived...
Abstract 4363902: Association of Moderate-Severe Tricuspid Regurgitation with Exercise Hemodynamics and Outcomes in Patients in Heart Failure with Preserved Ejection Fraction: Multicenter Study
Introduction: Tricuspid regurgitation (TR) is increasingly identified on resting echocardiography (TTE). Newly diagnosed severe TR and rate of progression from mild to severe TR ar...
Abstract 4364939: Impact of Obesity on Atrial Mechanical and Electrical Function in Patients Undergoing HFpEF Evaluation – A Propensity-Matched Analysis
Introduction: Obesity is a known risk factor for atrial fibrillation and heart failure with preserved ejection fraction (HFpEF). However, the specific mechanisms through which it a...
Abstract 4351571: Sleep, Cognition and Health among Adolescents with Congenital Heart Disease
Introduction: Sleep problems are common during adolescence. Additional impacts from congenital heart disease (CHD) may contribute to negative outcomes. Studies among adolescents wi...
Abstract 4363505: Transverse aortic stenosis (TAC) hearts based on NFAT-regulator of calcineurin-1 indicate nonlinear phenotypes coordinated with dysregulation of angiocrine-angiogenesis switch
Calcineurin (Cn) and NFAT activation contribute to cardiac hypertrophy. The Down syndrome critical region gene ( Dscr )-1 plays a crucial role in the feedback m...
Abstract 4367718: Influence of Heart Size and Sex on Cardiovascular Adaptations to 2 Years of Endurance Exercise Training in Sedentary Middle-Aged Adults
Background: Sedentary aging is linked to low cardiorespiratory fitness and poor cardiovascular health. People with smaller left ventricles, particularly females, are more likely to...
Abstract 4367415: Quality of Amiodarone Monitoring in a Veterans Affairs Healthcare System
Background: Amiodarone is widely utilized for managing atrial and ventricular arrhythmias, but is associated with pulmonary, liver, and thyroid toxicities. Previous studies demonst...
Abstract 4367370: Comparative Outcomes of Catheter Ablation for Atrial Arrhythmias in ATTR Cardiac Amyloidosis: A Systematic Review and Meta-Analysis
Introduction: Catheter ablation is an important rhythm control strategy for atrial arrhythmias. Arrhythmia recurrence rates are higher in amyloid than in non-amyloid populations. I...
Abstract Sun1301: Workplace-Driven CPR Training at Scale: Implementation of the HeartSafe Workplace Initiative in the RACE-CARS Trial
Background: Sudden cardiac arrest (SCA) is a leading cause of death in the U.S., yet bystander CPR rates remain low. Strategies are needed to expand CPR training to reach millions,...
Abstract 4357898: Aminoacylase-1 Regulates Hepatic Mitochondrial Respiration and Whole-Body Metabolism
INTRODUCTION/BACKGROUND: Using plasma proteomic profiling, we recently identified aminoacylase-1 (ACY1) as a top biomarker associated with metabolic dysfunction, including obesity,...
Abstract 4371831: Global Burden and Trends in Cardiovascular Disease Attributable to Dietary Risk Factors Among Women from 1990–2021: A Global Benchmarking Systematic Analysis
Background: Suboptimal dietary patterns constitute a leading modifiable risk factor for cardiovascular disease (CVD) in women, yet the global and temporal dynamics of diet related...
Abstract 4370976: Redefining Risk: Enhancing Prognostic Assessment in Primary Prevention with Coronary Artery Calcium Score
Introduction: Current CV prevention strategies focus on treating individuals based on estimated risk or clinical thresholds, but risk heterogeneity exists even within treatment-eli...
Abstract 4357288: Comparative evaluation of a proteomic cardiovascular risk assessment tool to coronary artery calcium score
Background: Coronary artery calcium (CAC) scores are a powerful measure for assessing atherosclerotic cardiovascular disease (ASCVD) burden and guiding preventative treatments. How...
Abstract 4364241: Echocardiographic Differences Between Acute Cellular and Antibody-Mediated Rejection in Heart Transplant Recipients
Background: Echocardiography is routinely used to evaluate heart transplant rejection, but phenotypic differences between acute cellular rejection (ACR) and antibody-mediated rejec...
Abstract Sat403: Automated Whole-Brain ADC Histogram Analysis for Neurological Prognostication in Post-Cardiac Arrest Patients: A Validation Study
Background: Apparent diffusion coefficient (ADC) from diffusion-weighted MRI reflects cytotoxic edema and enables neurological prognostication after cardiac arrest. However, curren...