Circulation
Articles in this Issue
Abstract 4352318: Interleukin-4 Exacerbates Doxorubicin-induced Cardiotoxicity by Promoting Cardiac Fibrosis and Apoptosis
Background: Doxorubicin (DOX) is a potent chemotherapeutic agent; however, its clinical use is limited by dose-dependent cardiotoxicity, leading to doxorubicin-induced cardiomyopat...
Abstract 4366786: New Technological Adoption of Robotics into Healthcare Systems: Healthcare Provider Perspectives
Background: While the implementation of robotics into daily healthcare task has the potential to revolutionize healthcare, the integration of robotics into routine clinical practic...
Abstract 4344131: Ecdysterone inhibits ferroptosis of endothelial cell by inhibiting NCF2 and activating PI3K/Akt/Nrf2 pathway to alleviate atherosclerosis
Background: Ecdysterone (Ecd), a bioactive compound derived from trianthema, exhibits potent anti-inflammatory properties. This study investigates the underlying mechanisms through...
Abstract 4366738: Coronary Artery Bypass Grafting Provides Better Long-Term Outcomes Compared To Percutaneous Coronary Intervention In Patients With Ischemic Heart Disease and Heart Failure with Ejection Fraction <35%: A Systematic Review and Meta-Analysis of Propensity-Score Matched Studies
Background: The comparable long-term benefits of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in patients with multivessel disease remains...
Abstract 4366633: Explainable Machine Learning for Risk Stratification of Major Adverse Cardiac Events Using Clinical and Imaging Data
Background: Accurate prediction of major adverse cardiac events (MACE) is critical for guiding cardiovascular care. Traditional risk scores such as the Pooled Cohort Equations (PCE...
Abstract Or104: The Benefits of Proactive Versus Reactive Rapid Response Activations
Introduction: Delays in ICU transfer are associated with increased hospital mortality. Rapid response systems are designed to identify and manage clinical deterioration earlier, an...
Abstract 4370908: Prednisolone has a Time-Dependent Shift in the effects on IL-1β Release: From Anti- to Pro-Inflammatory
Background: Pericarditis is the inflammation of the pericardial sac, and it has been associated with the activation of the NLRP3 inflammasome, which regulates Interleukin-1β (IL-1β...
Abstract 4367801: Tirzepatide Achieves Greater Weight and Blood Pressure Reduction Than Semaglutide in Routine Clinical Practice
Introduction: Although trials like SURMOUNT-5 demonstrated tirzepatide’s superiority over semaglutide in patients with obesity, real-world practice includes broader populations and...
Abstract 4359743: Exercise Response to Bisoprolol and Verapamil treatment in Non-Obstructive Hypertrophic Cardiomyopathy
Introduction: Beta blockers (BB) and calcium channel blockers (CCB) are recommended in non-obstructive hypertrophic cardiomyopathy (HCM) based on limited documentation....
Abstract 4368987: Exogenous Ketone Supplementation Restores Length-Dependent Activation In Human Hypertrophic Cardiomyopathy Myocardium
Introduction: Metabolic dysfunction in hypertrophic cardiomyopathy (HCM) is thought to both contribute to and result from disease progression. Small trials of therapeutic ketosis i...
Abstract 4345633: Left Atrial Lipomatous Metaplasia Quantified by Contrast-Enhanced Cardiac Computed Tomography in Patients with Atrial Fibrillation
Introduction/Background: Left atrial (LA) pericardial and epicardial fat are associated with atrial fibrillation (AF). However, the association of LA intramyocardial fat, i.e. lipo...
Abstract 4361318: Acute Mitral Inflow Obstruction Induces Left Ventricular Unloading Without Affecting Right Ventricular Hemodynamics in a Fetal Lamb Model
Introduction: Hypoplastic left heart syndrome (HLHS) is a severe congenital defect characterized by underdevelopment of the left ventricle (LV), requiring complex surgical palliati...
Abstract 4362513: J-shaped Association of Serum Hypoxia-inducible Factor 1α Levels With Incident Heart Failure in Patients With Stable Coronary Artery Disease: The ANOX Study
Background: Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a constitutively expressed β subunit (HIF-1β) and an oxygen-dependent α subunit (...
Abstract 4341712: <i>Mortality in Cardiac Complications of Heart Disease in the United States (1999–2023): A 25-Year Analysis of Trends and Sociodemographic Disparities from the CDC WONDER Database</i>
Background: Heart disease remains the leading cause of mortality in the U.S., with many patients experiencing life-threatening complications such as ruptured chorda tendinea, papil...
Abstract 4362463: Association between Toxic Metals exposure and Apolipoprotein among the USA population: A mixture Analysis from 2013-2016
Background: Toxic metals have been associated with a variety of chronic diseases. Apolipoprotein B (ApoB) is a marker of cardiovascular risk influenced by environmental metal expos...
Abstract 4363750: Physical Activity Change After Myocardial Infarction and Subsequent Risk of Cardiovascular Events
Introduction: Data are scarce regarding the long-term impact of physical activity (PA) change on new and recurrent ischemic events following myocardial infarction (MI). We hypothes...
Abstract 4360623: Three Limbs Is Better Than Two: Weathering Electrical Storm with Veno-Arterial-Venous Extracorporeal Membrane Oxygenation
Description of Case: A 58 year old man with non-ischemic cardiomyopathy (LVEF 21%) secondary to presumed (non-biopsy proven) cardiac sarcoidosis on prednisone and infliximab status...
Abstract 4339356: Paclitaxel distribution assessment after drug-coated balloon treatment in the superficial femoral artery: SNOW grade
Background: Drug-coated balloons (DCBs) are increasingly being used to treat superficial femoral artery (SFA) lesions during endovascular therapy (EVT). However, evaluation of pacl...
Abstract 4369824: Atrial Fibrillation and COVID-19: Disparities in Mortality and Clinical Outcomes
Introduction: While the respiratory symptoms of COVID-19 have been shown to contribute to poor outcomes, there is growing evidence that cardiovascular complications also contribute...
Abstract 4369800: Association of Inflammatory Hypertension with Left Ventricular Hypertrophy in Black Adults from the Genetic Epidemiology Network of Arteriopathy Study
Background: Hypertension and systemic inflammation are independently associated with adverse cardiovascular outcomes. While hypertension is a known risk factor for left ventricular...
Abstract 4365387: Intracellular β1AR-Phosphodiesterases 4D Axis Control Local ER Stress in HFpEF
Objective: Heart failure with preserved ejection fraction (HFpEF) is a major global health problem with limited therapeutic options. Despite its high prevalence, the molecular mech...
Abstract 4370743: Sex Differences in Cognitive and Psychosocial Outcomes in Adults with Moderate to Complex Congenital Heart Disease Compared to Controls
Background: Adults with moderate-to-complex congenital heart disease (CHD) show psychosocial and neurocognitive deficits, particularly in mood, anxiety, and cognitive domains. Howe...
Abstract 4368327: Targeting PDE4B (Phosphodiesterase-4 Subtype B) alleviates sepsis-induced multiple organ dysfunction via inhibiting endothelial cells pyroptosis
Introduction: Sepsis, a leading cause of mortality and critical illness globally, is a life-threatening condition due to dysregulated host immune response to infection, which may l...
Abstract 4369715: Hormone Replacement Therapy and Arrhythmia Risk in Menopause: A Comprehensive Nationwide Analysis
Background: Hormone replacement therapy (HRT) is commonly prescribed to alleviate menopausal symptoms, but its cardiovascular safety—especially its impact on arrhythmias and acute...
Abstract 4364730: Optimizing Pediatric Cardiology Referrals: A Six-Year Quality Improvement Project from a UK District General Hospital
Background: Paediatric cardiology referrals are increasing, placing pressure on district hospital services, with many not meeting criteria for specialist review. This QIP aimed to...