Circulation
Articles in this Issue
Abstract 4363265: Lipoprotein(a) Selectively Associates with Vulnerable Coronary Plaque Phenotypes in Comparison with Other Established Risk Markers
Background: Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk; however, its contribution to coronary plaque burden and composition, compared to traditional ri...
Abstract 4371299: Giant B cell Cardiac Lymphoma Presenting as SVC Syndrome: An unusual presentation of an unusual diagnosis
Background: Primary cardiac lymphoma (PCL) is an extremely rare malignancy, accounting for approximately 1–2% of primary cardiac tumors and about 0.5% of extranodal lymphomas. It p...
Abstract 4364098: Long-term Growth Trajectories of Ascending Aortic Aneurysm Demonstrate Low Utility of Extended Imaging Surveillance.
Background: Imaging surveillance for ascending thoracic aortic aneurysm (aTAA) relies on serial diameter measurements to guide management. However, measurement variability can lead...
Abstract 4371163: Stroke subtypes Loeys-Dietz and Vascular Ehlers-Danlos Syndromes: A Multicenter Retrospective Cohort Study
Background: Loeys-Dietz syndrome (LDS) and vascular Ehlers-Danlos syndrome (vEDS) are rare connective tissue disorders characterized by arterial fragility and early-onset vascular...
Abstract 4368781: Effects of Vutrisiran on Measures of Cardiac Structure, Function and Amyloid Burden by Cardiovascular Magnetic Resonance from the HELIOS-B Trial
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is caused by extracellular deposition of amyloid in the heart. Vutrisiran, an RNA interference agent, rapidly suppresses...
Abstract 4359074: The Artificial Intelligence-Derived Electrocardiographic Age Gap is Associated with Adverse Clinical Outcomes in Cardiac Laminopathy
Background: Disease-causative variants in LMNA -encoded lamin A/C cause the laminopathies, a heterogeneous group of diseases variably result...
Abstract 4339766: Efficacy of Olpasiran by Apolipoprotein(a) Isoform Size: Insights from the OCEAN(a)-DOSE Trial
Background: Lipoprotein(a) [Lp(a)] concentration is predominantly determined by genetics, with an inverse correlation between concentration and the number of Kringle IV-2 (KIV-2) r...
Abstract 4366084: BMI Thresholds and Incident ASCVD in Disaggregated Asian American, Native Hawaiian and other Pacific Islander Men and Women: The PANACHE Study
Introduction: Consensus guidelines recommend a lower BMI threshold in Asians for diabetes screening and ASCVD primary prevention strategies, but limited data exist about the associ...
Abstract 4371265: Outcomes of Expanded Criteria Donor Hearts in Adult Heart Retransplantation: A Propensity-Score Matched Analysis
Background: Heart retransplantation is a complex procedure limited by donor organ availability. The use of expanded criteria donor (ECD) hearts, which are defined by older donor ag...
Abstract 4346922: Neonatal Animal Model of Shunted Single Ventricle Circulation
Introduction/Background: Current knowledge of a Stage 1 shunted single ventricle (SSV) physiology is predominantly based on clinical data. Development of a reliable and reproducibl...
Abstract 4370995: The Combined Impact of Substance Use and Psychological Disturbances on Adverse Pregnancy Outcomes – A Propensity-Score Matched Analysis
Introduction: Substance use disorder (SUD) in pregnancy is associated with co-occurring psychological health conditions, and both are independently linked to an increased risk of a...
Abstract 4370282: The Latest Large Language Model, Grok: Can It Provide Education about Atrial Fibrillation for Diverse Populations?
Background: Large language models (LLMs) are used by atrial fibrillation patients. ChatGPT (OpenAI, San Francisco) and Grok (X.ai, San Francisco) have 450 M, 35 M monthly users, re...
Abstract 4365176: Impact of Insurance Payor on ICU Length of Stay Among Stroke Patients: A Retrospective Cohort Study Using MIMIC-IV
Introduction: Insurance payor is an important social determinant of health that may serve as a proxy for socioeconomic status and mediate outcomes in healthcare. In 2010, 14 percen...
Abstract 4369069: Feasibility of automated, deep learning-based segmentation of the Fontan aorta in 4D Flow MRI: A Fontan Outcome Registry using Cardiac Magnetic Resonance Examination (FORCE) Study
Background: In patients who have undergone Fontan palliation, suboptimal geometry of the reconstructed aorta may contribute to abnormal aortic blood flow patterns, ventriculo-vascu...
Abstract 4373447: Distinct Mechanisms of Mitochondria-rich extracellular vesicle Therapy in Acute vs. Chronic Ischemic Heart Failure: A Single-Cell Transcriptomic Study
Background: Disruption of mitochondrial energy metabolism plays a critical role in the pathophysiology of ischemic heart failure. We previously demonstrated that intramyocardial in...
Abstract 4367564: Predictors of Recurrent Infective Endocarditis Following Cardiac Surgery for Infective Endocarditis
Background: Infective endocarditis (IE) remains a heterogenous disease with high rates of adverse outcomes, and approximately half of the cases warrant cardiac surgery. Recurrent I...
Abstract 4366887: HS235, a Novel Activin Signaling Inhibitor, is Highly Efficacious in Preclinical Models of Pulmonary Hypertension and Heart Failure
Background: HS235 is an activin receptor (ActR)-based ligand trap designed to potently neutralize Activins and growth differentiation factors (GDFs) while sparing homeostatic bone...
Abstract 4369035: Multi-Omic Machine Learning for Predicting Outcomes in Heart Failure with Preserved Ejection Fraction (HFpEF): Insights from the UK Biobank
Background: Heart failure with preserved ejection fraction (HFpEF) is a syndrome that may manifest differently in different people, and doctors lack clear tools for predicting how...
Abstract Sat1402: Cardiac Arrest and Acute Respiratory Faliure-Related Mortality Trends in Adults in United States: A CDC WONDER Analysis from 1999-2023
Introduction: Cardiac arrest (CA), combined with acute respiratory failure (ARF), magnifies mortality. Stratified analyses concerning the interrelated national mortality trends and...
Abstract 4367114: Tachycardia-induced Cardiomyopathy from Incessant Atrial Tachycardia in a Teenager with Severe Pectus Excavatum
Description of Case: A 14-year-old male with a Haller Index of 6.1 was referred to cardiology clinic for evaluation of severe pectus excavatum (PE). He was asymptomatic but was inc...
Abstract 4339897: Lipid lowering effects of inclisiran in statin- or PCSK9i monoclonal antibody-intolerant patients
Introduction: Inclisiran is a small-interfering RNA therapy that lowered plasma LDL-C levels by ~50% at 90 days in placebo-controlled trials. The LDL-C lowering effects of inclisir...
Abstract 4368818: Evolving the Scribe: Leveraging Agentic AI for Clinical Documentation
Background: The burden of documentation has led to the adoption of Medical Scribes to ease Clinician workloads. However, Scribe duties have evolved beyond note taking; Pre-charting...
Abstract Sat705: Temperature Control after Paediatric Cardiac Arrest: A two part Systematic and Scoping Review
On behalf of the International Liaison Committee on Resuscitation (ILCOR) Pediatric Life Support Task Force. Background: Death and neurodisab...
Abstract 4348658: Titin hyperphosphorylation of skeletal muscle from heart failure with preserved ejection fraction patients is correlated with their peakVO <sub>2</sub>
Background: Heart failure with preserved ejection fraction (HFpEF) goes along with a variety of molecular alterations. Amongst others, dysregulation of titin in different heart fai...
Abstract 4346455: The ICAM1 p.K56M HFpEF Risk Variant and Measures of Adiposity
Introduction: Intercellular adhesion molecule (ICAM)-1 has been implicated in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The ICAM1 p.K56M variant (...