Circulation
Articles in this Issue
Abstract 4358298: Atrial Hypertrophy, Fibrosis and Compliance Loss in a Mouse Model of Heart Failure with Preserved Ejection Fraction
Background: Heart-failure with preserved ejection fraction (HFpEF) is traditionally viewed as a left-ventricular diastolic disorder, but is increasingly recognized as a multi-chamb...
Abstract 4363478: EN1 Attenuates Myocardial Delayed Reperfusion Injury by Enhancing Mitochondrial Respiratory Complex Expression via the PGC-1α/TFAM Axis
Background: Delayed reperfusion (DR) in myocardial ischemia contributes to significant cardiac injury, characterized by mitochondrial dysfunction, oxidative stress, and cardiomyocy...
Abstract 4372703: Sex-specific differences in the mechano-metabolic behavior of the myocardium in mice
Introduction: The pathophysiological mechanisms of left ventricular diastolic dysfunction (LVDD) involve impaired relaxation and restricted filling of the left ventricle (LV). Both...
Abstract 4363171: IRE1α Protects Against Cardiac Fibrosis via Selective Degradation of a Profibrotic Transcriptome
Background: Upon cardiac injury, cardiac fibroblasts (CFB) become activated and differentiate into myofibroblasts to maintain cardiac structure and function through secretion of st...
Abstract 4360333: Pulmonary Vein Isolation Combined With Linear Ablation Improves Outcomes in Persistent Atrial Fibrillation: A Systematic Review and Meta-Analysis of 1,431 Patients
Background: Persistent atrial fibrillation (AF) involves extensive atrial remodeling beyond pulmonary vein (PV) triggers, making catheter ablation less effective than in paroxysmal...
Abstract 4373162: Social Deprivation Score Derived from Principal Component Analysis of Survey Data Predictive of Cardiovascular Disease Risk in a National Cohort
Background: Cardiovascular disease (CVD) remains the leading cause of death globally, disproportionately affecting populations experiencing systemic barriers to healthcare. Althoug...
Abstract 4360639: The relationship between urinary manganese and heart failure: NHANES 2011-2018
Background: With the development of industrialization, manganese pollution in the environment has become increasingly common, but the relationship between manganese exposure and he...
Abstract 4366258: Safety and Hemostatic Efficacy of Prothrombin Complex Concentrate Versus Fresh Frozen Plasma in Patients undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis.
Introduction: In patients undergoing cardiac surgery, up to 15% experience major intraoperative and postoperative bleeding. Earlier research indicates excessive bleeding associated...
Abstract 4373249: Cardiovascular Disease Mortality in American Women: National Decline Masked by Rising Burden in Younger Age Groups (1999–2020)
Background: Cardiovascular disease (CVD) remains the leading cause of death among women in the United States. Understanding temporal and demographic trends in mortality is essentia...
Abstract 4368559: Twelve-month Changes in Lipid Management among Veterans who worked with a Health Coach vs. those who did not in the Veterans Affairs Lipid Optimization Reimagined Quality Improvement (VALOR-QI) Program
Background: Lipid management is critical for reducing cardiovascular events among those with atherosclerotic cardiovascular disease (ASCVD). Barriers to lipid management are multif...
Abstract 4368182: Oxygen Levels During Cardiopulmonary Bypass - Comparing Hyperoxia and Normoxia in Adult Cardiac Surgery: A Systematic Review and Meta-analysis
Background: The remarkable innovations in cardiac surgery enable surgeons to operate on a still heart while maintaining perfusion to vital organs. To offset reduced cardiac output...
Abstract 4362278: Ablation of Nephron Tubule Cell-Specific <i>Npr1</i> Triggers High Blood Pressure and Dysfunction
Introduction: Cardiac hormone, atrial and brain natriuretic peptides (ANP and BNP) activate guanylyl cyclase-A/natriuretic peptide receptor-A (GC-A/NPRA) and regulate intravascular...
Abstract 4366625: Ascending Thoracic Aortic Aneurysms in a Veterans Affairs Health System: Longitudinal Outcomes and Risk Factors
Introduction: The decision to perform ascending thoracic aortic aneurysm (aTAA) repair is primarily guided by diameter thresholds, but the optimal timing remains debated among guid...
Abstract 4361466: Association Between Antiphospholipid Antibody and Ischemic Stroke: A Systematic Review and Meta-Analysis
Background: Emerging evidence suggests that antiphospholipid antibodies (aPL) may be associated with an increased cardiovascular risk beyond the thrombotic antiphospholipid syndrom...
Retracted: Abstract 4349903: Exercise can alleviate hypertrophic cardiomyopathy induced by the novel <i>MYH7</i> T265I mutation
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder and the leading cause of sudden death in young individuals under 35 years of age. Mutation i...
Abstract 4355847: Trends in Ischemic Heart Disease Mortality Among Adults with Hyperlipidemia (1999-2023) in the United States
Background: Despite advances in hyperlipidemia therapies, ideal screening and control of lipids remains a challenge. This study aims to evaluate mortality trends associated with is...
Abstract 4366025: Association of education inequalities with premature cardiovascular mortality and its metabolic mediators: evidence from a nationwide cohort study
Background: Educational inequality is associated with a higher risk of mortality. However, studies exploring its association with premature cardiovascular disease (CVD) mortality a...
Abstract 4367655: Comparative Cardiometabolic Outcomes of Tirzepatide Versus Semaglutide in Patients with HFpEF and Obesity: A Real-World Multicenter Cohort Study
Background: HFpEF frequently coexists with obesity and type 2 diabetes, both of which are associated with adverse cardiometabolic outcomes. Glucagon-like peptide-1 receptor agonist...
Abstract 4360859: Feasibility, Acceptability, and Perspectives Towards Wearable Devices to Assess Life’s Essential 8 Among Home Health Aides
Background: Home health aides (HHAs) provide essential care to the growing population of older adults with cardiovascular (CV) disease who want to age in place. Despite their vital...
Abstract 4365061: Hemodynamic Stress in Aortic Regurgitation Alters Vascular Cell States and Promotes Aortic Wall Remodeling
Background: Fragility of the ascending aortic wall has been observed in patients with aortic regurgitation (AR), possibly due to turbulent retrograde flow. However, the underlying...
Abstract 4360945: Comprehensive Ranking of Maintenance Immunosuppressive Therapies for Heart Transplant Recipients: A Systematic Review and Bayesian Network Meta-Analysis
Introduction: Prior studies report mixed efficacy of maintenance immunosuppressive regimens in heart transplantation (HT). We conducted a network meta-analysis (NMA) to compare and...
Abstract 4370227: Acute Rhythm Change Reveals Atrial-Specific Metabolomic and Lipidomic Alterations in Atrial Fibrillation
Introduction: Arterio-venous (AV) gradients across tissue beds provide insights into the metabolic activity by measuring the net uptake or release of lipids and metabolites. In the...
Abstract 4370954: Trends and Disparities in Nicotine Dependence and Acute Myocardial Infarction–Related Mortality in the United States (1999–2020) Among Adults Aged ≥ 25: A CDC Wonder Perspective
Background: Nicotine use remains a major modifiable risk factor for acute myocardial infarction (AMI), contributing significantly to cardiovascular mortality in adults. Despite pub...
Abstract 4367285: Short-Term Determinants of Atrial and Ventricular Functional Mitral Regurgitation: Insights from Impulse Response Modeling
Background: Functional mitral regurgitation (FMR), both atrial (AFMR) and ventricular (VFMR), results from multiple interacting mechanisms including atrial and ventricular remodeli...
Abstract 4335977: Functionally Bicuspid Quadricuspid Aortic Valve with Mixed Valve Disease and Ascending Aortic Aneurysm
Description of Case: A 58-year-old man presented with progressive fatigue and dyspnea. Echocardiography showed mixed valve disease with severe aortic stenosis (AS), severe aortic r...