Circulation
Articles in this Issue
Abstract 4371507: Intersecting Maternity and Cardiology Care Deserts: Assessing the Impact on Maternal Hypertensive Outcomes in the U.S.
Background: Hypertensive disorders of pregnancy (HDP) are a major contributor to maternal mortality in the U.S. While the role of maternity care deserts regions lacking adequate ob...
Abstract 4357180: Autoimmunity and Cardiovascular Disease - Variable Development of Cardiac Phenotype in a Mouse Model with Programmed Cell Death Protein 1 Knockout
Background: Numerous studies indicate an association between cardiac dilation and autoimmune processes. Still, a deeper understanding of the mechanisms linking immune regulation an...
Abstract 4366239: Rare Variants in Cardiomyopathy and Channelopathy Genes are Associated with Severe Ventricular Arrhythmias in Mitral Valve Prolapse
Introduction: Mitral valve prolapse (MVP) is a common valvular disorder associated, in a minority of cases, with severe arrhythmic events including sudden cardiac arrest/death (SCA...
Abstract 4364935: Targeted Therapy Interrupted: Managing Hypertrophic Obstructive Cardiomyopathy in Pregnancy
Goals: To describe the clinical course of a 27-year-old woman with hypertrophic obstructive cardiomyopathy (HoCM) who developed a severe left ventricular outflow tract (LVOT) obstr...
Abstract 4366801: Role of ID1 and ID3 in the Pathogenesis of Idiopathic Pulmonary Fibrosis
Background: Idiopathic Pulmonary fibrosis (IPF) is a complex and deadly disease with limited treatment options. A better understanding of the cellular and molecular mechanisms invo...
Abstract 4365842: Chronic Aficamten Treatment Results in Sustained Favorable Cardiac Remodeling in Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the FOREST-HCM Trial
Background: Aficamten treatment over 24 weeks in SEQUOIA-HCM (NCT05186818) improved left ventricular (LV) outflow tract gradients (LVOT-G), showed evidence of favorable cardiac rem...
Abstract 4344023: Comprehensive Association of Frailty and TyG Index with Cardiovascular Disease in Middle-aged and Older Adults
Background: Frailty is a common condition in older adults, associated with an increased risk of cardiovascular disease (CVD). The triglyceride-glucose index (TyG), a marker of insu...
Abstract 4371654: Acceptability and Feasibility Of A Digital Health Intervention For Adults with Congenital Heart Disease
Background: Digital health offers a potential solution to support adults with congenital heart disease (CHD), filling the critical gap to help maintain recommended lifelong care wi...
Abstract 4363217: Prediabetes, Obesity and Risk of Cardiovascular Disease among 1.3 million Patients from an Integrated Health Care System
Background: Prediabetes is a precursor to type 2 diabetes and a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). There is concern for increasing the impa...
Abstract 4365024: Not All LDLs are Created Equal: Discordance Between Calculated LDL-C Estimates and Incident ASCVD in the Multi-Ethnic Study of Atherosclerosis
Introduction: The Friedewald equation (F-LDL-C) is the most widely used estimate of LDL-cholesterol (LDL-C), but it can be inaccurate at high TG and low LDL-C. The Martin-Hopkins (...
Abstract 4358994: Influenza Vs COVID-19 and Arrhythmic Events. A Propensity Matched Analysis
Background: The cardiovascular and mortality outcomes of COVID-19 versus influenza remain under study. This study aimed to compare these outcomes using a large real-world dataset a...
Abstract 4348765: Longitudinal Assessment of Myocardial Work Indices in Pediatric Heart Transplantation: A Novel Noninvasive Marker of Graft Function and Rejection Risk
Background: Routine surveillance of graft dysfunction in pediatric heart transplant recipients relies on invasive assessments by catheterization and biopsy. Noninvasive imaging tec...
Abstract 4366785: Efficacy and Safety of a Novel AAV <i>FXN</i> Gene Therapy (SGT-212) for the Treatment of Friedreich’s Ataxia
Introduction: Friedreich’s ataxia (FA) is an autosomal recessive neurodegenerative disorder caused by variants in the frataxin ( FXN) gene,...
Abstract 4365005: Fetal Ductus Arteriosus Constriction Associated with Unregulated NSAID and Corticosteroid Use During the Second and Third Trimesters in a Low-Resource Setting
Introduction: Premature closure of the ductus arteriosus (DA) is a rare but serious condition associated with significant fetal morbidity. Use of prostaglandin inhibitors such as n...
Abstract 4370574: Artificial Intelligence-Enabled Electrocardiography Demonstrates Strong Diagnostic Performance for Diastolic Dysfunction, Heart Failure with Preserved Ejection Fraction, and Left Atrial Enlargement: A Meta-Analysis
Introduction: Artificial intelligence (AI)-enabled electrocardiography (ECG) is redefining cardiac diagnostics by uncovering structural and functional abnormalities that human clin...
Abstract 4360733: Dose-Dependent Association between E-Cigarette Use and Sleep Duration among U.S. Adults
Background: While tobacco use is associated with poor sleep hygiene, there is a paucity of nationally representative data examining whether e-cigarettes (EC) may have a similar lin...
Abstract Sat1305: During endurance races: half of sudden cardiac arrest cases remain unexplained.
Background: Sport-related Sudden Cardiac Arrest (Sr-SCA) can occur even apparently healthy athletes. Cardiomyopathies and channelopathies have consistently been implicated as leadi...
Abstract 4364380: Outcomes of Coronary Chronic Total Occlusion Modification procedures
Background: Chronic total occlusion (CTO) modification procedures are defined as intentional balloon dilatation (diameter ≥2.0 mm) of the entire CTO, including the proximal and dis...
Abstract 4370136: Beyond the Octogenarian Threshold: A Nationwide, Multicenter Three-Year Analysis of Post-Ablation Safety Outcomes in Elderly Atrial Fibrillation Patients
Background: Evidence on the safety of atrial fibrillation (AF) catheter ablation in U.S. patients over 80 years old remains limited. With growing life expectancy, more elderly indi...
Abstract 4351158: Pharmacodynamics (PD) of a Subcutaneous (SC) Injection of a Novel-Formulation of furosemide (FUR)
Introduction: Furoscix 80 mg/10 mL is a buffered formulation of FUR that is self-administered SC via an On-body Infusor over 5 hrs. SCP-111 (FUR SC) is a novel-formulation of FUR 8...
Abstract 4364108: Sex Differences in Oxidative Stress and Contributing Factors in Patients with Metabolic Syndrome.
Background: Oxidative stress, an imbalance between oxidants and antioxidants, exacerbates metabolic syndrome and can worsen health outcomes. Females are at higher risk for inflamma...
Abstract 4336120: The prognostic implications of the left and right atrial strain in tuberculous pericarditis
Background: Tuberculous pericarditis (TBP) remains a life-threatening extrapulmonary manifestation of tuberculosis (TB), particularly in regions with high TB prevalence. It often p...
Abstract 4353895: The effectiveness of the GLP-1 receptors agonists in improving obesity-related heart failure events: A systematic review and meta-analysis of randomized clinical trials.
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have recently shown cardiovascular benefits regarding heart failure (HF). Emerging evidence suggests that GLP-1...
Abstract 4366267: Hospitalizations for Metabolic Dysfunction-Associated Steatotic Liver Disease Among Patients with Different Cardiovascular Disease
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease. Despite its rising burden, MASLD prevalence is likely...
Abstract 4364228: The Role of Sirtuin 6 in the Coronary Microvascular Dysfunction in Diabetes and Aging
Coronary microcirculation is essential to maintaining normal cardiac function. When the cardiac metabolic demand increases (e.g., exercise or stress), coronary blood flow increases accordingly to meet...