Circulation
Articles in this Issue
Abstract 4367697: High Burden of Cardiovascular-Kidney-Metabolic Syndrome Risk Factors Among Adolescents with Overweight or Obesity
Background: The cardiovascular-kidney-metabolic (CKM) syndrome is a driver of cardiovascular disease (CVD). Stage 2 CKM (metabolic risk factors or chronic kidney disease) is an imp...
Abstract 4365285: A Phase I, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of N-acetylgalactosamine Small Interfering RNA Conjugate, BPR-30221616, in Healthy Participants, for Potential Treatment of Transthyretin Amyloidosis
Introduction: Transthyretin amyloidosis (ATTR) is a progressive disease characterized by abnormal buildup amyloid of misfolded transthyretin (TTR) protein in multiple organs and th...
Abstract 4363697: Hybrid PET/MR Assessment of Left Ventricular Mechanical Synchrony and Intraventricular Blood Flow Energy in Ischemic Heart Disease
Background: The assessment of left ventricular (LV) mechanical synchrony using phase analysis (PA) provides incremental diagnostic value over conventional indicators and is widely...
Abstract 4365766: Geographic Disparities in Transthyretin Amyloid Cardiomyopathy Prevalence in United States Veterans
Introduction: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Recognition and diagnosis of ATTR-CM have increased due to greater awareness, im...
Abstract Sat1302: Urine Drug Screening Results in Overdose-Associated Cardiac Arrests
Background: Overdose continues to be a major public health problem. High potency fentanyl and derivatives as well as other substances and adulterants are present in varying degrees...
Abstract 4371080: Multimodal AI Integrating CMR, Demographics, and Lab Data Achieves High-Accuracy Cardiac Amyloidosis Subtyping with Interpretability and Uncertainty Quantification
Introduction: Accurate subtyping of cardiac amyloidosis (CA) into light - chain (AL) or transthyretin (ATTR) forms is essential for targeted...
Abstract 4365486: Artificial Intelligence Assisted Characterization of HFpEF in Patients with Indeterminate Diastolic Function
Background: Echocardiographic evaluation of diastolic dysfunction is often indeterminate and thus poses a challenge in assisting with diagnosing heart failure with preserved ejecti...
Abstract 4370652: SARM1-Associated NAD Loss Links Hypoxic Signaling to Metabolic Reprogramming in Diabetic Cardiomyopathy
Introduction: Diabetic cardiomyopathy (DC) is characterized by metabolic inflexibility, inductions of NAD loss and hypoxic signaling, and lipotoxicity....
Abstract 4365144: Glucagon-like-peptide-1 Receptor Agonists Are Associated with Lower Postoperative Complication Rates in Patients with Peripheral Artery Disease
Introduction: The American Diabetes Association recommends use of glucagon-like-peptide-1 receptor agonists (GLP-1RAs) by patients with peripheral arterial disease (PAD) despite li...
Abstract 4372740: Successful Right Subclavian Impella Placement in a Patient with Coarctation of the Aorta and Small Femoral Arteries: A Novel Access Approach for Mechanical Circulatory Support
Case Description: A 64-year-old male with a complex medical history, including mitral valve regurgitation/stenosis, severe aortic stenosis, mild coronary artery disease (CAD), coar...
Abstract 4368817: Genetic Evidence Suggests Combined Inhibition of Lipoprotein(a) and PCSK9 to Lower Atherosclerotic Cardiovascular Disease Risk.
Background: Elevated low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) [Lp(a)] are each independent drivers of atherosclerotic cardiovascular disease (ASCVD). Although...
Abstract 4370702: Proteomic Predictors of Incident Coronary Heart Disease in Individuals with CAC=0.
Introduction: Coronary artery calcium (CAC) is an increasingly important clinical marker of coronary heart disease (CHD) and disease progression. However, a significant proportion...
Abstract 4372631: Familial Clustering of Mital Valve Prolapse and Mitral Valve Regurgitation
Introduction: Studies have found significant familial clustering of mitral valve prolapse (MVP) and mitral valve regurgitation (MVR) in parent-child and sibling studies. However, g...
Abstract 4369911: Prevalence and Risk Factors for Ventricular Assist Device-Associated Infection in Children: An Analysis of the ACTION Registry
Background: Ventricular assist devices (VAD) are increasingly used to bridge children to heart transplant. Infection associated with extracorporeal VAD components remains a common...
Abstract 4344025: Is Periconceptional Folic Acid Supplementation Associated with Cardiovascular Disease Risk Later in Life among Women who Delivered a Child with Congenital Heart Disease?
Background: Elevated homocysteine levels are associated with increased risk of congenital heart disease (CHD) in offspring and cardiovascular diseases (CVDs) in adults. Folic acid...
Abstract 4369350: Understanding the spatial and temporal regulation of the β <sub>IV</sub> -spectrin/STAT3 complex in ischemic cardiac remodeling with spatial transcriptomics
Adverse fibrotic remodeling contributes to high morbidity and mortality in patients following myocardial infarction (MI). Healing after MI requires necrotic tissue to be cleared and replaced with fibr...
Abstract 4360134: Transcriptomic profiling of plasma microRNA reveals circulating biomarkers of transthyretin cardiac amyloidosis and dysregulated signaling pathways.
Background: Early diagnosis and initiation of disease modifying therapy for transthyretin amyloid cardiomyopathy (ATTR-CM) improves prognosis. However, ATTR-CM remains underdiagnos...
Abstract 4358742: Trends and Disparities in Mortality due to Obesity and Arrhythmias in the U.S: 1999-2023
Background: Obesity and arrhythmias are two converging epidemics contributing to rising cardiovascular mortality in the U.S. Yet, national-level mortality trends where both conditi...
Abstract 4357657: Comparative Evaluation of ChatGPT and DougallGPT on Interventional Cardiology Subspecialty Exam Content
Background: Large language models (LLMs) like ChatGPT and DougallGPT have shown growing potential in medical education. However, there are limited studies evaluating their performa...
Abstract 4368466: Estrogen Deficiency Exacerbates Cardiac Dysfunction in a Female Mouse Model of Cardiometabolic Injury Via Phospholamban Modulation
Introduction: After menopause, estrogen levels decline, increasing the prevalence of cardiovascular disease in post-menopausal women. Ca2+ handling alterations have been reported i...
Abstract 4363106: Real-World Effectiveness of Evolocumab in Reducing Major Adverse Cardiovascular Events in Patients With Atherosclerotic Cardiovascular Disease
Background: Evolocumab significantly reduces major adverse cardiovascular events (MACE) in patients with atherosclerotic cardiovascular disease (ASCVD) in randomized controlled tri...
Abstract 4349330: Bispecific Activation of GC-A and GLP-1 Receptors: A Novel Peptide Therapeutic for Cardiometabolic Diseases
Introduction: Diabetes mellitus (DM) is strongly associated with metabolic and cardiorenal derangements. Natriuretic peptides (NPs), and glucagon-like peptide 1 receptor agonists (...
Abstract 4346072: Overall, Race and Regional trends in Ischemic heart disease mortality among adults with Chronic Kidney Disease: Insights from CDC WONDER (1999–2020)
Background: Chronic Kidney Disease (CKD) and Ischemic Heart Disease (IHD)-related mortality is a significant burden among US adults. This study investigates trends in CKD and IHD-r...
Abstract 4370820: The role of dietary micronutrient insufficiency in the association of diet monotony with time to hospitalization or death in patients with heart failure: A mediation analysis
Background/Introduction: Dietary micronutrient insufficiencies, which are common in patients with heart failure (HF) and linked to event-free survival (time to hospitalization or d...
Abstract 4369627: Association Between the Hemoglobin-to-Red Cell Distribution Width Ratio and Mode of Death in Patients With Acute Decompensated Heart Failure: A Stratified Analysis by Ejection Fraction
Background: The hemoglobin-to-red blood cell distribution width ratio (HRR), an indicator of inflammation, is acknowledged as a promising new prognostic biomarker and has been repo...