Circulation
Articles in this Issue
Abstract 4366045: Healthcare Providers Conceptions of Chest Pain Differ from the Lay Public
Introduction: Chest pain is the most common symptom of ACS. The term chest pain is an umbrella term, and patients often describe chest symptoms using other terms leading them to de...
Abstract 4368730: NEDD9 Inhibition Reverses Fibrotic Remodeling In Experimental Pulmonary Arterial Hypertension
Introduction: Pulmonary arterial hypertension (PAH) is characterized by a fibroproliferative vasculopathy that narrows distal lung arterioles due to pulmonary artery endothelial an...
Abstract 4365367: Targeting SARM1 NAD hydrolase for therapy of cardiometabolic diseases by regulating mitophagy and mitochondrial respiration
Background: Cardiac NAD decline is reported in cardiometabolic diseases. SARM1 consumes NAD in axonal injury and causes mitochondrial dysfunction, but its role in heart disease is...
Abstract 4372706: Percutaneous Valve Implantation in Pulmonary Artery Branches for Severe Pulmonary Regurgitation Secondary to Native Valve Endocarditis
Background: Percutaneous treatment of pulmonary valve disease is a safe and minimally invasive alternative with favorable mid-term outcomes, especially in congenital heart disease....
Abstract 4367328: Mutations in the C-terminal of the KCNJ2 gene increase the odds of sudden cardiac death in Andersen-Tawil Syndrome.
Background: Andersen-Tawil Syndrome (ATS) is an autosomal dominant disorder marked by dysmorphic features, periodic paralysis, and ventricular arrhythmias. While the overall risk o...
Abstract 4367427: A Multimodal Artificial Intelligence Signature of Advanced Cardiac and Vascular Aging Defines Elevated Risk of Cardiovascular Disease
Background: Age is the strongest factor in current cardiovascular risk estimation tools, yet there is significant heterogeneity in chronological age as a proxy for biological decli...
Abstract 4338185: Is the Benefit of a Supportive Intervention for Heart Failure Caregivers Sustained Over Time?
Background: Caregiving is stressful, and caregivers commonly neglect self-care. We tested the effectiveness of virtual health coaching and demonstrated at 6 months that self-care,...
Abstract 4363930: Higher fibroblast activation protein identifies improved myocardial plasticity and positive response to cardiac resynchronization therapy
Background: Fibroblast activation protein (FAP) has been shown to be elevated in patients post-MI and may be associated with the development of HFrEF. However, whether and to what...
Abstract 4357452: Glucagon-Like Peptide-1 Receptor Agonists Show Varied Impact on Venous Thromboembolism Risk: A Comprehensive Bayesian Network Meta-Analysis of Randomized Controlled Trials
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in diabetes management, but their association with venous thromboembolism (VTE), including de...
Abstract 4345643: Prognostic Value of Right Ventricular Strain in Intermediate-Risk Pulmonary Embolism: An External Validation Study
Background: Intermediate-risk pulmonary embolism (PE) is common and associated with significant mortality. We previously demonstrated that right ventricular global longitudinal str...
Abstract 4367196: Intake of Fiber From Different Food Sources and Type 2 Diabetes Risk: An Integrated Analysis of Epidemiological and Multi-Omics Data
Background: Dietary fiber intake has been associated with a lower risk of type 2 diabetes (T2D). However, the association between fiber from various food sources and T2D risk remai...
Abstract 4365779: Bempedoic acid exerts antioxidant and anti-inflammatory effects and inhibits OxLDL-induced human coronary artery smooth muscle cell migration, proliferation and proinflammatory phenotype changes
Dyslipidemia contributes to oxidative stress, inflammation, and the dedifferentiation, migration, and proliferation of vascular smooth muscle cells (SMCs), ultimately promoting the development and pro...
Abstract 4351680: Madly Dangerous: Unmasking the Arrhythmogenic Nature of Valvular Heart Disease
A 36-year-old woman (G2P1) at 8 weeks gestation, with a few days of nonbilious vomiting, presented following an out-of-hospital ventricular fibrillation (VF) cardiac arrest. Return of spontaneous circ...
Abstract 4358025: County-Level Social Disadvantage Independently Predicts Higher Risk-Adjusted Heart Failure Hospitalization Rates in the United States
Background: Heart failure (HF) is a major cause of morbidity and hospitalization in the United States. Place-based social determinants of health, including community-level vulnerab...
Abstract 4368552: Management of unsuccessful defibrillation therapy in patients with implantable cardiac devices
Background: Unsuccessful defibrillation therapy in patients with implantable cardiac defibrillators (ICDs) and ventricular tachytherapies may occur due to patient and/or device rel...
Abstract 4370610: Sirolimus Versus Paclitaxel-Coated Balloon Angioplasty for Coronary Artery In-Stent Restenosis: A Meta-Analysis and Trial Sequential Analysis
Background: While sirolimus-based drug-eluting stents have shown better outcomes than paclitaxel-based stents, it remains unclear whether the same advantage exists when these agent...
Abstract 4366434: Non-Invasive Estimation of Pulse Wave Velocity in Pregnant Women Using a Wearable Smart Ring
Background: Pulse wave velocity (PWV) is a marker of arterial stiffness and cardiovascular risk. While conventionally measured using tonometry or oscillometric systems, recent adva...
Abstract 4360749: Prevalence and Risk Markers for Heart Failure in Hypertrophic Cardiomyopathy: A Multicenter Cross-Sectional Study With Central Assessment of Biomarkers and Echocardiograms
Background: Heart failure (HF) in hypertrophic cardiomyopathy (HCM) is poorly characterized, especially in patients with preserved left ventricular ejection fraction (LVEF). Clarif...
Abstract 4369283: Artificial Intelligence (AI) empowered Fetal Echocardiography - A Meta-Analysis Exploring its Image Processing and Diagnostic Prowess
Artificial Intelligence (AI) models have the potential to revolutionize fetal echocardiography, enhancing image processing and diagnostic capabilities. There is promise in AI's potential to improve th...
Abstract 4365395: Comparison of Echocardiographic Pulmonary Artery Pressures to Pulmonary Artery Catheter Pulmonary Pressures in Patients on Peripheral VA-ECMO in an Academic Tertiary Care Hospital
Introduction: In patients requiring extracorporeal membrane oxygenation (ECMO), monitoring pulmonary artery systolic pressure (PASP) and assessing right ventricular (RV) function i...
Abstract 4365673: Incidence of Spontaneous Heart Block in L-looped Ventricles
Introduction: Patients with L-looped ventricles are at risk for the spontaneous development of complete heart block; however, the incidence rate is poorly understood. The goal of t...
Abstract 4369976: Anemia and Hemodynamic Changes in Heart Failure: Insights from HeartLogic Monitoring
Introduction: Anemia is a recognized marker of poor outcomes in various conditions. Several trials have explored the prognostic implications of treatment of anemia or iron deficien...
Abstract 4368806: Vitamin E is Differentially Associated with Cardiometabolic Risk and Metabolic Syndrome in Brazilian and U.S. Hispanic/Latino Populations
Introduction: Vitamin E (α-tocopherol) is a lipid-soluble antioxidant with anti-inflammatory effects, studied for its role in managing metabolic syndrome (MetS). This is especially...
Abstract 4362717: Combinatorial Transcription Factor Gene Transfer Accelerates Direct Reprogramming of Ventricular Myocytes to Pacemaker Phenotype
Background: We previously demonstrated that re-expression of the embryonic transcription factor TBX18 is sufficient to reprogram ventricular myocytes (VMs) into sinoatrial node (SA...
Abstract 4365866: Beta-Blocker Therapy After Acute Myocardial Infarction in Patients with Mildly Reduced or Preserved Ejection Fraction: An Updated Meta-Analysis
Background: Current guidelines recommend beta-blocker use after myocardial infarction (MI), however, Recent data has challenged the utility of beta-blockers in patients with preser...