Circulation
Articles in this Issue
Abstract 4368794: Plaque and Coronary Artery Characteristics in Patients With Myocardial Bridging With and Without Hypertrophic Cardiomyopathy: A Propensity-Matched Analysis
Background: Myocardial bridging (MB) occurs when an epicardial coronary artery traverses into the myocardium. There are limited data comparing plaque characteristics of patients wh...
Abstract 4370357: Effect of COVID-19 on Pediatric Population and Congenital Heart Disease: A Comprehensive Examination of Outcomes, Vaccination Effectiveness, and Healthcare Inequalities
Background: Children with congenital heart disease (CHD) represent a vulnerable population with heightened susceptibility to respiratory infections. However, comprehensive data cha...
Abstract 4352302: Differential Pathophysiological Mechanism of Exercise Intolerance in Non-Obese Versus Obese Patients with Heart Failure and Preserved Ejection Fraction
Background: Diffuse myocardial fibrosis contributes to diastolic dysfunction and may impair exercise capacity in patients with heart failure and preserved ejection fraction (HFpEF)...
Abstract 4370864: Point-of-care Non-invasive Classification of Elevated Intracardiac Filling Pressures for Congestion Assessment
Background: Pulmonary capillary wedge pressure (PCWP) provides an objective assessment of congestion status in heart failure (HF) patients, but its use is limited by the need for a...
Abstract 4371023: Prevalence of Adiposity-Based Chronic Disease in Iranian Adults
Background: The Adiposity-Based Chronic Disease (ABCD) model is designed to assess the diagnosis, and the prevalence of adiposity and health risks associated with it. The aim of th...
Abstract 4370378: Camera is All You Need: Low-cost Atrial Fibrillation Detection using Facial Remote Photoplethysmography
Introduction: Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias, yet current screening and monitoring methods require contact-based electrocardiographic (EC...
Abstract Sun806: Use of ETCO <sub>2</sub> Guided Cardiopulmonary Resuscitation in a Pediatric Swine Model of Ventricular Fibrillation Cardiac Arrest
Introduction: Conventional cardiopulmonary resuscitation (CPR) guidelines fail to account for variability in the physiologic response to resuscitation potentially limiting effectiv...
Abstract 4362806: Effect of Glucagon-like peptide-1 Receptor Agonists on Cardiac Arrhythmias: Systematic Review and Meta-analysis
Background and Aims: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed the management of type 2 diabetes mellitus(T2DM) and overweight/obesity, and are increasi...
Abstract 4370008: Markov Chain Modeling of Postoperative Hemodynamics and Vasoplegia After Cardiac Surgery Using a Novel Resistance Flow Ratio based State Definition
Introduction: Understanding postoperative hemodynamic progression following cardiac surgery is critical for effectively managing patient outcomes. Traditional methods inadequately...
Abstract 4348059: Genetic Variants Drive Phenotypic Diversity and Adverse Outcomes in Left Ventricular Hypertrabeculation
Background: Left ventricular hypertrabeculation (LVHT), often also known as left ventricular non-compaction, describes a cardiac phenotype characterized by prominent trabeculae and...
Abstract 4361617: Recovery of Aortic Wall Structure in Mouse Models of Marfan Syndrome with Conditional Inactivation of ADAMTS6
Background: Marfan syndrome (MFS), a complex multisystem disorder, is caused by autosomal dominant mutations in the FBN1 gene, leading to a...
Abstract 4358726: ZEB1 Regulates Coronary Disease Risk Through Epigenetic Control of Smooth Muscle Cell Identity
Background: Vascular smooth muscle cells (SMCs) contribute significantly to heritable coronary artery disease (CAD) risk and undergo phenotypic transitions in the intimal plaque du...
Abstract 4358975: Maternal Diabetes Tips the Scale: Unmasking Hidden Notch Mutations in Outflow Tract Development
Background: Congenital heart disease (CHD) is the most common birth defect and pregestational maternal diabetes is a modifiable risk factor associated with CHD. It’s estimated that...
Abstract 4370314: Declining Mortality From Myocardial Infarction in CKD Stage 3 and Above: Persistent Sex and Racial Disparities in the United States, 1999–2020
Background: Chronic kidney disease (CKD) stage 3 and above is strongly linked with increased cardiovascular mortality. Myocardial infarction (MI) in this population carries a parti...
Abstract 4361308: Tirzepatide Reduces the Risk of Major Adverse Cardiovascular Events: An Individual Participant Data Meta-analysis of Phase 3 Randomized Clinical Trials
Background: Individual participant data (IPD) from Phase 3 trials of tirzepatide offer a unique opportunity to evaluate its CV efficacy and identify response correlates. These insi...
Abstract 4344222: All Magnesium-Based Bioresorbable Scaffolds in patients with CAD: A Proportional Meta Analysis
Background: Coronary artery disease (CAD) is often managed through percutaneous coronary intervention with stent implantation to restore and maintain vessel patency. Metallic stent...
Abstract Sun303: Impact of COVID-19 pandemic for out-of-hospital cardiac arrest patients who received extracorporeal pulmonary resuscitation in Japan
Background: The influence of COVID-19 for out-of-hospital cardiac arrest (OHCA) who received extracorporeal pulmonary resuscitation (ECPR) was not fully elucidated. We examined whe...
Abstract 4366165: High-Fidelity, Low-Cost Extraction of Valvular Disease Parameters from Echocardiography Reports Using Rule-Based NLP
Background: Extraction of data from transthoracic echocardiography (TTE) reports is critical for cardiovascular research, particularly in valvular heart disease. While machine lear...
Abstract 4368890: Cholesteryl Ester Transfer Protein (CETP) Inhibition with Obicetrapib Produces Substantial Reductions in LDL Particles: Pooled Analysis of BROOKLYN and BROADWAY Phase 3 Clinical Trials
Background: Low-density lipoprotein (LDL) particle number is an important predictor of cardiovascular risk compared to LDL cholesterol concentration alone, reflecting actual athero...
Abstract 4342985: Utilization of Advanced Diagnostics in Younger Adults with First Unexplained Ventricular Tachycardia, Ventricular Fibrillation or Cardiac: A U.S. Based Multicenter Cohort Study
Background: Current studies evaluating diagnostic testing in younger adults with first ventricular fibrillation (VF), tachycardia (VT) or cardiac arrest is largely limited to terti...
Abstract 4360616: Cardiovascular magnetic resonance imaging estimation of diffuse myocardial and hepatic fibrosis late after tetralogy of Fallot repair
Background: Cardiovascular magnetic resonance imaging (CMR) can estimate diffuse myocardial fibrosis using extracellular volume fraction (ECV) quantification....
Abstract 4364758: A Novel tRNA-Derived Small RNA, tRF-1:32-Glu-TTC-2-M2, Regulates Right Ventricular Remodeling and Fibrosis by Targeting P4HA2 in Pulmonary Arterial Hypertension
Background: Right ventricular (RV) function is the principal determinant of exercise capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite its clini...
Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population
Background: Advances in pediatric oncology have led to a growing population of childhood cancer survivors (CCS), who are at increased risk for cardiovascular disease (CVD). Most ex...
Abstract 4369298: Feasibility, Safety and Intraprocedural Device Outcomes of Dual-Chamber Leadless Pacemakers: A Systematic Review and Single-Arm Meta-Analysis
Introduction: Dual-chamber leadless pacemakers (dcLP) represent an innovative advancement in cardiac pacing, aiming to provide atrioventricular (AV) synchronous pacing without the...
Abstract 4370456: Multiparameter Assessment of TNNI3 Cardiomyopathy Variants for Precision Medicine
Introduction: Genetic testing for cardiomyopathies has become routine in clinical practice, yet current testing strategies primarily determine the presence of a probable pathogenic...