Circulation
Articles in this Issue
Abstract 4369641: The impact of renal injury markers on bleeding risk in chronic kidney disease and atrial fibrillation patients receiving rivaroxaban
In patients with chronic kidney disease (CKD), the presence of concomitant atrial fibrillation (AF) increases both the risk of thromboembolic complications and the risk of bleeding associated with the...
Abstract 4369691: Effects of Impella 5.5 on Right Ventricular Load and Adaptation
Background: Right ventricular failure (RVF) is a leading source of morbidity following durable LVAD implantation. Some propose using Impella 5.5 support as a surrogate “RV stress t...
Abstract 4356994: Blood Metabolomic Atlas for One-Hour Post-Load Glucose Predicts Long-Term Glycemic Dynamics and Cardiometabolic Disease Incidence
Background: Elevated 1-hour glucose levels during a 75g oral glucose tolerance test (OGTT) are strong predictors of progression to type 2 diabetes (T2D) and chronic metabolic disea...
Abstract 4359477: Evaluation of PREVENT Equations for Estimating Cardiovascular Disease Risk in Individual Asian American and Native Hawaiian and Pacific Islander Groups
Background: The race-free Predicting Risk of cardiovascular disease (CVD) EVENTS (PREVENT) equations estimate 10-year risk for total CVD. However, their accuracy in individual Asia...
Abstract 4367842: Prognostic Value of Persistent Microvascular Injury in patients with ST-Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention: A MR study
Background: This study aimed to investigate the prevalence, clinical characteristics, and prognostic significance of persistent microvascular injury (PMI) in ST-Segment Elevation M...
Abstract 4361568: Improving Cerebral Oxygenation Monitoring with Advanced Diffuse Optical Spectroscopy in Children with Cyanotic Congenital Heart Defects
Abstract Body (2500): Introduction: Accurate quantification of cerebral oxygenation is critical for managing children with congenital heart defects (CHD) during pediatric critical...
Abstract 4369452: Multidimensional Dietary Patterns and Mortality: Interplay of Diet Quality and Chrononutrition Metrics in Mortality Risk among United States Adults
Introduction: Diet is multidimensional encompassing the quantity, quality, and timing of food intake. Diet quality and chrononutrition metrics have been independently linked to car...
Abstract 4362436: GARP deletion in myeloid cells ameliorated cardiac remodeling following myocardial infarction
Cardiac remodeling involves diverse types of myeloid-derived cells, including macrophages and neutrophils. While the general significance of myeloid cells is recognized, precise roles of these cells r...
Abstract 4367825: Impact of SGLT2 Inhibitor Use on Cardiac Allograft Vasculopathy and Other Clinical Outcomes in Heart Transplant Recipients: A Propensity-Matched Real-World Study
Background: Cardiac allograft vasculopathy (CAV) and transplant rejection are major contributors to late morbidity and mortality following heart transplantation. Sodium-glucose co-...
Abstract 4349177: Adiposity and Cardiac Function in South Asian Americans: Findings from the MASALA Study
Background: Higher body mass index (BMI) has been associated with worse echocardiographic parameters. Few studies have examined the influence of adiposity on cardiac function in So...
Abstract 4366043: Kounis Syndrome: Keeping the heart Bee-zy!
Background: Kounis syndrome (allergic angina syndrome) is triggered commonly by drugs, insect bites and even ice cream, causing myocardial infarction (MI). Treating this with the t...
Abstract 4363142: Human Bone Marrow Adipose Tissue Functions as a Hematopoietic Niche for Leptin-Driven Monopoiesis
During peripheral vascular disease and aging, adipose tissue within the bone marrow expands while the trabecular red marrow contracts. The impact of these changes on blood cell formation remains uncle...
Abstract 4367851: Incidence and Causes of Sudden Deaths with History of Atrial Fibrillation and Effect of Anticoagulant/Antiplatelet Therapy on Hemorrhagic Causes: from the POST SCD Study
Background: Atrial fibrillation (AF) is the most common arrhythmia, and studies have reported increased risk of heart failure and sudden cardiac death (SCD). However, the proportio...
Abstract 4364612: Apolipoprotein A2 as Protection Against Increased Mortality After Aortic Aneurysm Repair
Aim: The prognosis of patients with aortic aneurysm (AA) and cardiovascular comorbidities remains suboptimal compared with that of the general population, highlighting the need for...
Abstract 4369223: Demographic and Regional Disparities in Mortality due to Congenital Heart Diseases Among Adults in the United States: Insight from a 24-Year Retrospective Analysis
Backround: Advances in care have significantly improved survival for those with congenital heart disease (CHD), creating a growing adult CHD population. However, a limited number o...
Abstract 4364865: Left Ventricular Function Recovery Following Spontaneous Coronary Artery Dissection: A Multicenter Retrospective Study
Background: Spontaneous coronary artery dissection (SCAD) is increasingly recognized as a cause of acute coronary syndrome, particularly in young to middle-aged women. While most p...
Abstract 4370062: Vascular Leak Index Predicts Postoperative Fluid Accumulation Following Cardiac Surgery
Introduction: Postoperative vascular leak and the associated fluid retention are frequent and clinically significant complications in patients following cardiac surgery. Despite th...
Abstract 4370615: Distinct Roles For CD36 Dependent Versus Independent Transendothelial Delivery And Uptake by Cardiomyocytes Are Revealed by Coordination With Vectorial Acylation by Esterification to Acyl-CoA.
Background: The heart primarily relies on long-chain fatty acids (LCFAs) for energy, utilizing endothelial (EC) and cardiomyocyte (CM) CD36 transporters for respective delivery to...
Abstract 4369514: Spot-Urine Sodium Monitoring After IV Loop Diuretics: An Overlooked Predictor of Early Death? A Real-World Multi-Center Study of 11 Million Heart Failure Patients
Background: Outcomes of patients with acute decompensated heart failure (ADHF) remain suboptimal. Loop diuretics are first-line therapy in ADHF patients and low urinary spot sodium...
Abstract 4339143: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke
BACKGROUND: Patients with prior ischemic stroke are at high risk for recurrent stroke and other major adverse cardiovascular events (MACE). The incremental benefit of achieving ver...
Abstract 4363565: Risk Stratification After Myocardial Infarction: Functional Recovery is More Important Than Tissue Recovery
Background: Microvascular obstruction (MVO) and LVEF are key prognostic factors post-STEMI. Although persistent MVO often correlates with poorer LVEF, MVO resolution (tissue recove...
Abstract 4358093: Clinical Utility and Transethnic Calibration of Polygenic Risk Scores for Myocardial Infarction: A Global Meta-analysis Across Diverse Genetic Ancestries
Background: Polygenic risk scores (PRS) offer promising avenues for stratifying myocardial infarction (MI) risk and informing precision prevention. However, most PRS are derived fr...
Abstract 4369214: Global Variation in Cardiovascular Disease Burden, 1990–2021: Comparative Trends in the United States, Europe, Asia, and Latin America
Background: Despite widespread advances in cardiovascular disease (CVD) prevention, regions vary substantially in their progress. Quantifying regional patterns can identify where t...
Abstract 4366455: Comparison of Patient Demographics between New and Existing Heart Transplant Centers
Introduction: There have been increasing numbers of heart transplants performed yearly in the United States, but significant waitlist times and patient disparities remain. Multiple...
Abstract 4366860: Hormonal Therapy and the Risk of Cardiovascular Diseases Among Men with Prostate Cancer
Background: Hormonal therapy (HT) is a cornerstone of prostate cancer treatment; however, its potential cardiovascular risks remain a clinical concern. This study evaluated the inc...