Circulation
Articles in this Issue
Abstract 4370601: Efficacy of Icosapent Ethyl for Cardiovascular Risk Reduction by Aspirin Use in REDUCE-IT
Background: Icosapent ethyl, a purified eicosapentaenoic acid, has demonstrated CV risk reduction. Emerging evidence suggests that the antiplatelet effects of icosapent ethyl may c...
Abstract 4368203: A validated metabolite-based biomarker score for fruit and vegetable intake and associations with all-cause mortality and incident cardiometabolic diseases
Background: Epidemiological evidence underlying beneficial associations of fruit and vegetable intake with all-cause mortality and cardiovascular diseases largely relies on subject...
Abstract 4371766: Trends of Acute Myocardial Infarction and Ventricular Arrhythmias Related Mortality in the United States from 1999–2020
Background: Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. Ventricular arrhythmias (VAs), including ventricular tachycardia and ven...
Abstract 4362202: Combined associations of GLP-1 medications and healthy lifestyle with cardiovascular outcomes among individuals with diabetes: The Million Veteran Program
Background: Incidence of diabetes in the US has more than doubled in the last 20 years, affecting more than 30 million adults. It is unclear what the combined effect of lifestyle h...
Abstract 4358648: Prokaryotic Voltage-Gated Sodium Channel (BacNav) Gene Therapy Restores Contractile and Electrical Function in a Rat Model of Chronic Ischemia-Reperfusion Heart Failure
Introduction: Following infarction, heart often undergoes pathological remodeling and dysregulation of sodium and calcium homeostasis, predisposing patients to heart failure and ar...
Abstract 4362682: Trends in Stroke Mortality Among Older Adults (≥65 years) With Chronic Kidney Disease in the U.S. From 1999 to 2020
Background: The U.S. population is aging alongside rising rates of chronic kidney disease (CKD). However, trends in stroke-related mortality among adults with CKD particularly thos...
Abstract Sun1403: A Case of Successful Resuscitation After Out-of-hospital Cardiac Arrest Caused by Undiagnosed Pheochromocytoma-induced Cardiomyopathy
Case Presentation: A 50-year-old man experienced unintended weight loss and required more intensive antihypertensive therapy over the preceding several months prior to presentation...
Abstract 4368645: Double X, Double Trouble: Unveiling the Clotting Risk in Klinefelter Syndrome
Background: Klinefelter syndrome (KS), the most common sex chromosome aneuploidy in males (47,XXY), is generally associated with hypogonadism, gynecomastia, and infertility. Nevert...
Abstract 4364790: Cyclohexanone Exposure in a Neonatal Rat Model Activates the Peripheral Immune System and Alters Neurological Function
Introduction: Congenital heart disease repair is commonly associated with neuro-developmental abnormalities that affect quality of life. Cyclohexanone (CXO) is an industrial solven...
Abstract 4368251: Mitochondrial-Targeted Therapies in Ischemic Cardiomyopathy: A Systematic Review of Preclinical and Clinical Evidence (2000–2025)
Background: Ischemic cardiomyopathy (ICM) is characterized by energy failure, oxidative stress, and cardiomyocyte death—processes heavily influenced by mitochondrial dysfunction. T...
Abstract Sun1103: Performance Improvement Initiative: Resuscitation Related Metrics
In response to updated Joint Commission standards on resuscitation practices in Critical Access Hospitals, this quality improvement initiative aimed to develop a structured approach for capturing and...
Abstract 4370035: Cardiac Complications During Delivery in Hypertensive Disorders of Pregnancy: A Multicenter Outcomes Study, 2022-2025
Background: Hypertensive disorders of pregnancy (HDP) elevate the risk of cardiovascular complications during and after delivery, contributing to both short-term morbidity and long...
Abstract 4373694: Changes in the Plasma Proteome with Acute Exercise: The Dallas Heart Study
Introduction Resting-state plasma proteins are predictive of exercise performance, but limited data exist regarding acute changes in the plasma proteome with exercise....
Abstract Sun905: Improving Time to First Defibrillation in In-Hospital Cardiac Arrests Through a Multidisciplinary, Simulation-Based Intervention
Background: Timely defibrillation is critical for survival in patients experiencing in-hospital cardiac arrest with shockable rhythms. Despite this, delays remain common in complex...
Abstract 4359051: Optimal Reclassification of Aortic Aneurysms: Computed Tomography VS. Transthoracic Echocardiography
Background: Ascending aortopathy (AA) is mostly asymptomatic and often incidentally diagnosed using cardiac imaging (either transthoracic echocardiography [TTE] or computed tomogra...
Abstract 4364838: Distribution and clinical impact of polygenetic risk scores in younger subjects at uncertain coronary risk
Background: Assessment of coronary artery disease (CAD) risk using risk scores and coronary artery calcium (CAC) is not predictive in younger individuals. Additionally, patients wi...
Abstract 4362446: Sleep as a Mediator Between Stress and Blood Pressure in Older African American Women: RiSE Study
Introduction: African American women (AAW) are disproportionately affected by psychosocial stress and hypertension. While stress is recognized as a cardiovascular risk factor, the...
Abstract 4369679: Plasma Protein Biomarkers of Coronary Artery Ectasia Based on Multiple Cohort Studies
Background: Coronary artery ectasia (CAE), defined as pathological coronary dilation exceeding 1.5 times the diameter of adjacent normal segments, is a complex cardiovascular disor...
Abstract 4370584: The Statin Shortfall: Lower Statin Use in Autoimmune Disease Despite Elevated Cardiovascular Risk Across LDL-C Levels.
Background: It is well known that patients with autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus are at increased risk for atherosclerotic cardio...
Abstract 4366370: Rare Case of Reverse Takotsubo Cardiomyopathy Associated with VZV-Induced CNS Vasculitis in a Postpartum Patient
A 27-year-old woman on 4th postpartum day presented to ED with fatigue, dysphagia, and chest tightness. Appeared anxious and had sinus tachycardia. Labs revealed leukocytosis, elevated hsTrop, and pro...
Abstract 4369662: Declining Endurance in Children: A Systematic Review of Endurance Times using the Bruce Protocol since 1978
Background: The Bruce treadmill protocol is a commonly used protocol for treadmill-based exercise testing in children. However, normative data for endurance time dating from 1978 r...
Abstract 4340495: Assessing the Economic and Healthcare Burden of Atherosclerotic Cardiovascular Disease in Type 2 Diabetes: A Microsimulation Approach to Cost-Effectiveness and Resource Utilization
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that requires effective management strategies to optimize long-term health outcomes. While metformin is...
Abstract 4361354: Microbubbles In the Pericardial Space: An Unusual Echocardiographic Finding
Background: Hydropneumopericardium is a term used to describe accumulation of fluid as well as air in the pericardial space. Air or microbubbles in the pericardial space are rare f...
Abstract 4360259: Meta-analysis of outcomes with pulsed-field ablation vs. cryoablation in atrial fibrillation patients
Background: Pulsed-field ablation (PFA) is a nonthermal ablation method for pulmonary-vein isolation to treat atrial fibrillation. Limited data is available to compare PFA with cry...
Abstract 4364267: Population Changes in AI Coronary Plaque Volumes over 7 Years
Background: We sought to benchmark long-term changes in coronary artery plaque volumes by creating nomograms from AI-enabled coronary plaque analysis (AI-CPA), derived from a large...