Circulation
Articles in this Issue
Abstract 4364797: Trends in Nonalcoholic Steatohepatitis and Congestive Heart Failure Mortality in the United States from 1999 to 2020: A Comprehensive Analysis
Background: Metabolic-dysfunction associated steatohepatitis (MASH), previously nonalcoholic steatohepatitis (NASH), and congestive heart failure (CHF) are rising public health con...
Abstract 4370848: Prognostic Value of Left Atrial Strain in Predicting Atrial Fibrillation Recurrence After Catheter Ablation
Background: Left atrial (LA) strain is a marker of atrial myopathy and remodeling. While echocardiographic LA strain is increasingly used to assess atrial function, the prognostic...
Abstract 4360776: Consumption of Eicosapentaenoic Acid Reduces Cardiovascular Mortality Risk in Peripheral Artery Disease Patients
Background: Peripheral artery disease (PAD), affects >200 million globally, is linked to reduced quality of life and increased cardiovascular mortality. Standard care emphasizes...
Abstract 4360688: Trends of Ventricular Fibrillation Related Mortality in Patients with Chronic Ischemic Heart Disease and Chronic Kidney Disease: A CDC Wonder Analysis 1999-2023
Background: Ventricular fibrillation (V-fib) is a leading cause of sudden cardiac death, particularly in patients with comorbid chronic ischemic heart disease (CIHD) and chronic ki...
Abstract 4361657: Exacerbation of Doxorubicin-Induced Mitochondrial Dysfunction by the Inhibition of Voltage -Dependent Anion Channel 1 Oligomerization
Background: Doxorubicin-induced cardiomyopathy is a widely used model of heart failure associated with mitochondrial dysfunction. Voltage-dependent anion channel 1 (VDAC1) oligomer...
Abstract 4353134: Explainable Deep Learning Predicts Future Adverse Outcomes in Non-Ischemic Cardiomyopathy From Multi-domain Digital Health Data
Background: Despite recognized phenotypic heterogeneity of idiopathic non-ischemic cardiomyopathy (NICM), management remains generalized and dominantly guided by left ventricular (...
Abstract 4364419: Anti-CD47 therapy induces early macrophage-specific transcriptomic changes associated with the resolution of inflammation in a murine model of atherosclerosis
Background: We previously reported that anti-CD47 therapy reduces atherosclerosis development in a preclinical Apoe null mouse model. After 12 weeks of treatment (10mg/kg), signifi...
Abstract 4343947: Treatment Patterns and Outcomes of Papillary Muscle Rupture: A Comparative Analysis of MitraClip Versus Mitral Valve Replacement Using a National Inpatient Database
Background: Papillary muscle rupture (PMR) is a devastating mechanical complication of acute myocardial infarction and carries a high mortality for which the current definitive tre...
Abstract 4348146: Predictors of Delay in Seeking Treatment Taiwanese Patients with Acute Coronary Syndrome
Background: Acute coronary syndrome (ACS) requires immediate medical attention to reduce morbidity and mortality. However, prehospital delay remains a global challenge, leading to...
Abstract 4366581: Prevalence and Impact of Sepsis on In-Hospital Outcomes in Children With Congenital Heart Disease in a Tertiary LMIC Center: Identifying Early, Modifiable Predictors of Poor Outcomes
Background: Congenital heart diseases (CHD) are among the most common congenital malformations, with sepsis and lower respiratory tract infections significantly contributing to mor...
Abstract 4344273: Distinguishing Syndromic and Nonsyndromic Familial Aortopathies Using Electronic Health Record and Genetic Data from the <i>All of Us</i> Research Program
Familial aortopathies are inherited conditions that weaken the aortic wall and may be classified as syndromic, affecting multiple organ systems (e.g., Marfan syndrome), or nonsyndromic, where disease...
Abstract 4355664: A Woman's Heart: Unveiling CMD as the Cause of Recurrent Syncope
Case Description: A 42-year-old female with migraines and recent history of quitting smoking presented to the ED after two syncopal episodes within a month. Initial EKG and cardiac...
Abstract 4349201: Differential Associations by Sex Between Sleep-Wake Regularity and All-Cause and Cardiovascular Mortality
Introduction: Highly irregular sleep-wake timing is prospectively associated with higher all-cause and cardiovascular (CVD) mortality rates. These relationships are hypothesized to...
Abstract 4366291: Plasmalemma Vesicle-Associated Protein (PLVAP) Maintains Cardiac Endothelial Barrier function via ARNT-dependent mechanism
Background: Microvascular endothelial dysfunction is a key contributor to cardiac injury in cardiovascular diseases. Plasmalemma vesicle-associated protein (PLVAP) is a structural...
Abstract 4337642: Genomic Insights into Cardiometabolic Risk and Admixture Patterns in Black Hawaiians
Black Hawaiian (BH) individuals, or Popolo, are a Native Hawaiian and Pacific Islander (NHPI) group characterized by significant African ancestry and a unique sociocultural history. Despite their dist...
Abstract 4363378: Mitral E Wave Deceleration Slope as a Predictor of Clinical Outcome In Pulmonary Hypertension
Background: Deceleration time (DT) of mitral E wave is a well-researched predictor of clinical outcome in cardiovascular patients. It reflects cardiac chamber stiffness or impaired...
Abstract 4359700: Age-linked PVAT dysfunction and sex-specific signatures: Unveiling the pathobiology and phenotypes associated with CABG graft patency
Background: The efficacy of coronary artery bypass grafting (CABG) is often compromised by graft failure, particularly in elderly and female patients, who exhibit higher occlusion...
Abstract 4358074: Prescription Patterns for Antithrombotic Therapy Following Peripheral Vascular Interventions
Introduction: There is no established consensus on the optimal antithrombotic regimen following peripheral vascular intervention (PVI), although the most recent AHA guidelines reco...
Abstract 4373256: BMP9 drives vasoactive gene expression in endothelial cells via non-canonical ALK1-SMAD3 signaling
Rationale: The role of BMP9 in pulmonary arterial hypertension (PAH) remains controversial. Loss-of-function GDF2 /BMP9 mutations in heritab...
Abstract 4369890: Duration of Antiplatelet Therapy and Risk of MACE in Patients With Coronary In-Stent Restenosis Treated With Second-Generation Drug-Eluting Stents or Drug-Coated Balloons
Research Question: Does the impact of dual antiplatelet therapy (DAPT) duration on outcomes after in-stent restenosis (ISR) differ between patients treated with drug-eluting stents...
Abstract 4363465: Differential Outcomes of TAVR With and Without Percutaneous Coronary Intervention During Same Hospitalization
Background: Transcatheter aortic valve replacement (TAVR) has emerged as a transformative, minimally invasive alternative to surgical aortic valve replacement for patients with tri...
Abstract 4359940: Behaviorally-Designed Gamification Increases Physical Activity Among Breast and Prostate Cancer Survivors: The ALLSTAR Randomized Clinical Trial
Background: Breast and prostate cancer survivors are at high risk of cardiovascular events due to cardiotoxic therapies. Physical activity is associated with better outcomes in the...
Abstract 4373355: Association Between Healthy Vascular Aging and Intrinsic Frequencies of Carotid Pressure Waveform: The Framingham Heart Study
Introduction: Healthy Vascular Aging (HVA) refers to the preservation of vascular function with advancing age, challenging the common belief that hypertension and increased arteria...
Abstract 4367980: Can IVUS Predict Aortic Remodeling? The Role of Flap Mobility in Type B Aortic Dissection With TEVAR
Background: The optimal timing of preemptive thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD) remains controversial. In the chronic phase, favorable...
Abstract 4371337: Impact of Antiarrhythmic Use on Primary Graft Dysfunction in Orthotopic Heart Transplant Patients: A Single Center Retrospective Cohort Study
Introduction: Orthotopic heart transplantation is the definitive treatment for end stage heart failure leading to improved quality of life. Primary Graft Dysfunction (PGD) is one o...