Circulation
Articles in this Issue
Abstract Sat207: Relationship between Duty Cycle and Indicators of Hemodynamics in Circumferential Thoracoabdominal Cardiopulmonary Resuscitation
Introduction: In CPR, duty cycle (DC) is the fraction of time dedicated to chest compression or constriction within each chest compression/relaxation cycle. Traditionally, 50% has...
Abstract 4359280: Serum Metabolomics Detects and Grades Heart Transplant Allograft Acute Cellular Rejection
Background: Acute cellular rejection (ACR) remains a major challenge after orthotopic heart transplantation (OHT). Surveillance relies on endomyocardial biopsy (EMB), an invasive t...
Abstract 4371704: Duration of Potent P2Y12 Inhibitor-Based DAPT after Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Frequentist Pairwise and Network Meta-Analysis
Introduction: Dual antiplatelet therapy (DAPT) for 12 months is recommended as the standard strategy following percutaneous coronary intervention (PCI) in patients with acute coron...
Abstract 4358890: Left Ventricular Ejection Fraction as a Prognostic Marker Across Gradient and Flow Subtypes in patients with severe aortic stenosis undergoing SAVR or TAVR: Insights from CURRENT AS Registry 2
Background: The prognostic significance of left ventricular ejection fraction (LVEF) has been reported in patients with severe aortic stenosis (AS), but remains inconclusive in tho...
Abstract 4370290: An Inflammatory Dilemma: Human Metapneumovirus-Associated Pericarditis in a Solitary Kidney Host
Human metapneumovirus (hMPV) is a well-known paramyxovirus that has primarily been associated with respiratory illness. Extrapulmonary complications, such as pericarditis and pericardial effusion, are...
Abstract Sat302: Quantification of Neuronal Damage after Cardiac Arrest Using Machine Learning
Background: Brain injury is a major cause of death and disability after cardiac arrest (CA). Quantitative histology enables the assessment of neuronal damage in preclinical models...
Abstract 4360705: Intensive Versus Standard Blood Pressure Control in Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis
Background: Hypertension (HTN), a prevalent comorbidity in type 2 diabetes mellitus (T2DM), increases the risk of cardiovascular (CV) events, mortality, and kidney complications. H...
Abstract 4369952: A Royal Flush: A Unique Case of Carcinoid Heart Disease Manifesting in a Rare Fashion as Quadruple Valve Involvement
A 56-year-old woman presented to her primary care physician with a 1-year history of facial flushing and short-lived paroxysms of chest pain. An electrocardiogram was performed which showed normal sin...
Abstract 4373706: In vivo conversion of ferric heme to NO-ferroheme has vasodilatory and anti-inflammatory effects
Background: Increased levels of cell-free hemoglobin (Hb) and ferric heme in plasma is vasculopathic and contributes to morbidity and mortality in hemolytic and non-hemolytic disea...
Abstract 4370724: Impact of the COVID-19 Pandemic on Cardiovascular deaths among individuals with Cancer in the United States (2018-2023): A nationwide analysis from CDC WONDER database
Background: The COVID-19 pandemic disrupted healthcare access and delivery for vulnerable populations, including individuals with cancer....
Abstract 4355405: Association of Adverse Pregnancy Outcomes with Long-Term Risk of Cardiovascular Disease and Risk Factors in a Diverse Cohort
Background: Adverse pregnancy outcomes (APOs) are increasingly recognized as risk indicators for future cardiovascular disease (CVD), yet their long-term implications across divers...
Abstract 4366122: Outcomes of Transcatheter Mitral Repair in Cardiogenic Shock With and Without Mechanical Circulatory Support
Background: Severe mitral regurgitation (MR) in cardiogenic shock (CS) presents unique therapeutic challenges, especially in patients with prohibitive surgical risk. Transcatheter...
Abstract 4362825: Aspirin for Primary Prevention of Cardiovascular Events in Patients with Diabetes Mellitus: An Updated Systematic Review, Meta-Analysis&Trial Sequential Analysis of Randomized Controlled Trials post-ASCEND Trial
Introduction: Patients with diabetes mellitus are at increased risk of cardiovascular events such as myocardial infarction, stroke, and cardiovascular death. While aspirin’s role i...
Abstract 4339615: Allograft Outcomes of Adding Proprotein Convertase Subtilisin Kexin 9 Inhibitors or Ezetimibe to Statin Therapy in Heart Transplants Recipients at High Risk of Cardiac Allograft Progression: A Multicenter Target Trial Emulation
Introduction: Proprotein convertase subtilisin kexin 9 inhibitors (PCSK9i) and ezetimibe improve cardiovascular outcomes in patients with inadequate lipid control. Current literatu...
Abstract 4369956: A Single Parasternal-long-axis-view-sweep of the Heart (SPLASH) + color Doppler Screening Protocol for the Detection of Hypertrophic Cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiac disease, yet it remains profoundly underdiagnosed; it is estimated that 6 out of 7 (86%) individu...
Abstract 4347325: Plasma Metabolomics and Machine Learning Identify Causal Metabolic Contributors to Incident Heart Failure in 38,628 MGB Biobank Participants
Background: The growing prevalence of cardiometabolic risk factors creates a need for deeper understanding of the metabolic pathways that promote cardiac dysfunction and heart fail...
Abstract 4366106: Fluidic Shear Stress Has Opposing Effects on Clathrin-Mediated Endocytosis in Vascular Endothelial Cells
Clathrin-mediated endocytosis (CME) is a significant route of internalization for macromolecules and membrane receptors in eukaryotic cells such as vascular endothelial growth factor (VEGF), VE-cadher...
Abstract 4370101: Optimizing Cardiovascular Outcomes in Hypertensive Patients with Obstructive Sleep Apnea: A Systematic Review of CPAP and Adjunctive Therapies
Background: Obstructive sleep apnea (OSA) is frequently found in individuals with hypertension and is a recognized contributor to adverse cardiovascular (CV) outcomes. While Contin...
Abstract 4372241: Prevailing Language Discordance is associated with Worse Post-operative Outcomes in Adult Cardiac Surgical Patients
Background: Language discordant with the prevailing language in a region has a negative association with a person’s ability to seek and receive medical care, though there is no spe...
Abstract 4366347: Temporal Shifts in Cardiovascular Death Among Patients with Cancer: 25-Year Analysis in the United States
Background: Cardiovascular disease and cancer share overlapping risk factors, and as cancer survival improves, a growing population of survivors faces long-term cardiovascular risk...
Abstract 4370545: β-Hydroxybutyrate Inhibits Thoracic Aortic Aneurysm and Dissection in Mice by Suppressing Ferroptosis
Background: Thoracic aortic aneurysm and dissection (TAAD) is a severe vascular disease that poses life-threatening risks. Unfortunately, managing and treating TAAD remains challen...
Abstract 4361336: Exploring Disparities in Pediatric Wolff-Parkinson-White Patients by Race and Ethnicity: Results of a Multicenter Ambispective Registry
Background: Social determinants of health —including socioeconomic status, race and ethnicity, and access to care—affect health outcomes and contribute to disparities in disease bu...
Abstract 4372407: Improvement of Detection of Pulmonary Thromboembolism in Patients Who Were Suspected of Having Pulmonary Thromboembolism Using Lung Tissue Denaturation by Spectral CT
Introduction: On CT, small size pulmonary artery (PA) thrombus is sometimes difficult to detect and diagnostic accuracy depends on the physician’s skill....
Abstract 4369982: Hypertension-Associated Accelerated Brain Aging - An Analysis from the UK Biobank Cohort
Background: Hypertension is a major modifiable risk factor for cerebrovascular diseases, with early onset impacting brain health. However, the quantifiable neuroimaging features of...
Abstract 4364206: Recurrent PEA Arrests due to Coronary Vasospasm in the Absence of Obstructive CAD
Introduction: Coronary vasospasm is a transient, reversible narrowing of the coronary arteries that may lead to myocardial ischemia, arrhythmias, or cardiac arrest. Diagnosis is pa...