Circulation
Articles in this Issue
Abstract 4369738: Where Cardiac Arrest Claims: A Mapping of End-of-Life Care by Demographics and Region, 1999–2024
Introduction/Background: Cardiac arrest caused >9M U.S. adult deaths (1999–2024). Place of death reflects end-of-life care quality. While home/hospice deaths rose for other cond...
Abstract 4368713: Implantable Intramyocardial Sensor for Continuous Monitoring of Ventricular Function
Background: Heart failure management increasingly requires accurate, continuous assessment of left ventricular (LV) function, including parameters such as systolic and end-diastoli...
Abstract Sun1304: TRAINING IN BASIC LIFE SUPPORT AND PEDIATRIC EMERGENCIES FOR EDUCATORS: EVALUATION OF THE EFFECTIVENESS OF THEORETICAL AND PRACTICAL TRAINING
Introduction: Choking and drowning are frequent causes of death in children, as they can quickly lead to cardiorespiratory arrest (CRA) in out-of-hospital settings. The American He...
Abstract 4364899: Trends and Disparities in Genetic Testing Among Patients at Risk for Heritable Thoracic Aortic Disease: A Multicenter Cohort Study
Introduction: Heritable thoracic aortic disease (HTAD) encompasses a spectrum of genetic syndromes and mutations that increase the risk of aortic aneurysm, dissection, and rupture....
Abstract 4363374: Correlates of Nocturnal Hypertension in a Real-World Cohort
Background: Nocturnal hypertension (NH) is associated with adverse cardiovascular outcomes beyond and independent of daytime hypertension (DH). Although cohort studies have evaluat...
Abstract 4342954: Racial Disparities in Cardiovascular Outcomes Among Women with Polycystic Ovarian Syndrome: A Propensity-Matched Analysis Using the TriNetX Research Network
Background: Polycystic ovarian syndrome (PCOS) is associated with increased cardiovascular risk factors, but racial disparities in cardiovascular outcomes among women with PCOS rem...
Abstract 4368252: A Novel Role for ANPEP in Osteogenic Signaling and Aortic Valve Calcification
Introduction: Calcific aortic valve disease (CAVD) is one of the most common valvular diseases, predominantly characterized by progressive calcification of the aortic valve. Althou...
Abstract 4347706: Acute Effects of Isometric Handgrip Exercise on Cardiac Baroreflex Sensitivity in Chronic Kidney Disease
Background: Patients with chronic kidney disease (CKD) exhibit impaired spontaneous cardiac baroreflex sensitivity (cBRS) that can contribute to poor blood pressure (BP) control an...
Abstract 4369994: Impact of Sodium Glucose Cotransporter 2-Inhibitors in Valvular Heart Disease
Introduction: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardiovascular benefits in randomized trials, including reductions in mortality and heart failure hospi...
Abstract 4367749: Cancer Accelerates Atherosclerosis via a TNF-Driven Angiogenic Pathway
Background: Cardiovascular disease (CVD) and cancer are the leading causes of global mortality, and emerging evidence indicates a complex, bidirectional relationship between these...
Abstract 4367687: Development of Personalized Myocardial Surface Mesh Models with LGE Scar Integration: a Pipeline for Machine Learning and Digital Twins
Introduction: Advances in cardiac imaging offer new insights into the electrophysiologic correlates of myocardial fibrosis and scarring. Applications taking advantage of cardiac ma...
Abstract 4365181: The Association of Cardiac Structure and Function with Incident Stroke in Patients with Heart Failure with Preserved Ejection Fraction: Insights from the TOPCAT and PARAGON-HF Trials
Backgrounds: Stroke is a major complication in patients with heart failure with preserved ejection fraction (HFpEF), associated with significant morbidity and mortality. However, p...
Abstract 4373675: Relationship Between Characteristics of Peri-Left Ventricular Summit Adipose Tissue and Number of Ventricular Arrhythmias on Holter ECG in Patients with Atrial Fibrillation Scheduled for Pulmonary Vein Isolation
Introduction: The left ventricular (LV) summit (LVS) is the highest point on the epicardial surface of the LV and is located in the LV myocardium just adjacent to and between the p...
Abstract 4363501: Revisiting Physical Activity Recommendations: Personalized Strategy Considering Risk Stratification
Introduction: The “one-size-fits-all” recommendations in current physical activity (PA) guidelines have been challenged, and optimal PA patterns across individuals with varying pre...
Abstract 4365564: DNA methylation undermines FCGR2A's protective role in Myocardial Infarction
Background: Myocardial infarction (MI) is one of the leading causes of death throughout the world. Despite advances in treatment, the molecular mechanisms underlying MI remain poor...
Abstract 4368654: Quantitative assessment of myocardial stiffness by three-dimensional ultrasound shear wave elastography in cardiac amyloidosis patients
Background: Cardiac Amyloidosis (CA), particularly transthyretin amyloidosis (ATTR) is characterized by the deposit of amyloid proteins in the extracellular matrix of myocardium le...
Abstract 4370479: Tocilizumab: Potential Protective Effects Against Acute Kidney Injury and Cardiorenal Dysfunction
Cardiovascular diseases can lead to acute kidney injury (AKI) through cardiorenal syndrome by reducing renal blood flow and increasing venous congestion. Accordi...
Abstract 4364915: Early Percutaneous Ventricular Assist Device Use Is Associated with Higher In-Hospital Mortality in Non-Ischemic Cardiogenic Shock: A National Inpatient Sample Analysis
Background: Cardiogenic shock (CS) is a life-threatening condition of inadequate organ perfusion due to cardiac failure. Although inotropes and vasopressors are standard treatments...
Abstract 4368718: Heart Transplant Outcomes in Donor After Circulatory Death vs Donor After Brain Death Donors for Patients Bridged with HeartMate 3 Devices.
Introduction: The number of heart transplants (HT) with donor after circulatory death (DCD) donors has increased. Outcomes for DCD donors compared to donor after brain death (DBD)...
Abstract 4368793: Economic Consequences of Increased Cardiopulmonary Clinical Encounters due to Distant Canadian Wildfire Smoke Exposure
Background: Wildfire smoke (WFS) events pose hazard to cardiopulmonary (CPM) health, and are expected to increase in intensity and frequency. In June 2023, western Canadian WFS dri...
Abstract 4363554: Anthracycline Cardiotoxicity in Cancer Patients with HIV
Background: Those living with HIV are at an increased risk for cardiac dysfunction and clinical heart failure compared to people without HIV. Persons with HIV are also at an increa...
Abstract 4361556: Evaluating Sex-Related Disparities in Cardiovascular Risk Factors and INTERHEART Risk Score Among Asian, African, and Hispanic Communities in Philadelphia, PA
Background: Cardiovascular (CV) diseases significantly contribute to morbidity and mortality in U.S minority communities. However, sex-related disparities within ethnic groups are...
Abstract 4370952: Temporal Trends and Disparities in Mortality From Cardiac Arrest and Sudden Cardiac Death–Related Mortality in U.S. Adults With Diabetes: A National Population-Based Analysis
Introduction: Sudden cardiac death (SCD) and cardiac arrest are major causes of mortality in individuals with diabetes, who are at increased risk due to autonomic dysfunction, acce...
Abstract 4369581: Clinical Event Adjudication Using a Human-Machine Hybrid Modeling Approach
Introduction: In clinical trials, adjudication of clinical events is crucial for ensuring reliable outcomes. This process is entirely manual and requires many hours of work from He...
Abstract 4337649: The Toothpaste Heart: Striking Imaging of a Multisystem Calcific Cardiovascular Case in a Young Male with ESRD
Introduction: Extensive vascular and valvular calcification is typically seen in older adults with longstanding cardiovascular disease. In younger patients, it often reflects compl...