Circulation
Articles in this Issue
Abstract 4342633: Artificial Intelligence-Enhanced Electrocardiography Detects Hypertrophic Cardiomyopathy in Patients at High Risk of Sudden Cardiac Death
Background: Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising tool for detecting hypertrophic cardiomyopathy (HCM). While demonstrating high s...
Abstract 4364099: Electronic Health Literacy Influences Chronic Disease Self-Management among Adults
Background: Inadequate self-management behaviors (e.g., not taking medications as prescribed) result in poor patient outcomes. eHealth literacy—the digital skills needed to seek an...
Abstract Sat1202: Hemodynamic Effects of Resuscitative Endovascular Balloon Occlusion of the Aorta Deflation in Normal Physiological Conditions and After the Return of Spontaneous Circulation Following Cardiac Arrest
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) therapy augments circulation to the heart and brain during cardiopulmonary resuscitation (CPR). Howeve...
Abstract 4346502: Unequal Access: Socioeconomic Deprivation Associated with Increased Travel Distance to Phase III Lipid-Lowering Drug Trials in the Southern United States
Background: Early adoption of PCSK9 monoclonal antibodies and small-interfering RNA therapies depends on clinical-trial access. Yet communities with the highest cardiovascular burd...
Abstract 4361520: Social Vulnerability and Deprivation Indices Predict Excess Hypertension-Related Hospitalizations Across U.S. Counties
Background: Prevention quality indicators in inpatient settings, such as hypertension-related hospitalizations (HRH), are population-based admissions that can be prevented through...
Abstract 4353913: A pharmacist-led, population health approach to optimizing care in patients with hypertension and type II diabetes mellitus in minority groups
Background: There are significant disparities in the care of patients from minority racial/ethnic groups with diabetes and hypertension. We deployed a pharmacy-led approach, paired...
Abstract 4354856: Pathological mechanisms of Down syndrome-associate pulmonary arterial hypertension
Background: Down syndrome (DS) is the most prevalent chromosomal disorder, caused by trisomy of human chromosome 21. DS is associated with an increased incidence of pulmonary arter...
Abstract 4363412: Discontinuation of Beta-Blockers After Acute Coronary Syndrome: A Systematic Review and Meta-Analysis
Introduction: The optimal duration of beta-blocker (BB) therapy after myocardial infarction remains uncertain in patients without heart failure, especially given their frequent lif...
Abstract 4364391: Artificial Intelligence-Powered Electrocardiogram to Detect Acute Coronary Obstruction in Patients with Suspected Acute Coronary Syndrome
Background: ST-elevation on a 12-lead ECG helps identify occlusion myocardial infarction (OMI) requiring emergent invasive coronary angiography (ICA) and revascularization. However...
Abstract 4359776: Adverse Childhood Experiences, Genetic Predisposition, and Lifestyle Factors: Roles in Cardiometabolic-Depression Multimorbidity Trajectories
Background: Adverse Childhood Experiences (ACEs) have profound effects on physical and mental health across the lifespan. However, how ACEs influence the co-occurrence and progress...
Abstract 4367525: Inhibition of PDE10A Attenuates Pressure Overload-induced Right Ventricular Dysfunction via Modulation of Calcium Signaling and β-Catenin Pathways
Introduction: Right ventricular (RV) dysfunction is an independent predictor of poor outcomes in heart failure. However, the molecular mechanisms of RV remodeling remain unclear. P...
Abstract 4366367: Cardioprotection in a Rat Model of Ischemic Injury by a Novel Anti-CD47 Fusion Protein
Background: To prevent secondary necrosis and prolonged inflammation following cardiac ischemia, efficient clearance of dying cardiomyocytes must occur. CD47 is a “don’t eat me” si...
Abstract Sun702: Unexpected Delays: Breathing Diagnostic Tool Associated with Compression Interruptions Without Clear Survival Benefits
Introduction: The Medical Priority Dispatch System (MPDS) includes a Breathing Verification Diagnostic Tool (BVDxT) to help emergency dispatchers assess breathing effectiveness in...
Abstract 4365757: Acculturation and Cardiovascular-Kidney-Metabolic Syndrome: a Study of Immigrant Adults From the National Health and Nutrition Examination Survey
Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome describes the interaction between cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic dysfunction...
Abstract Sun405: Effect of Prophylactic Antibiotics on Days of Antibiotic Spectrum Coverage in Comatose Post-cardiac Arrest Patients: A <i>Post-hoc</i> Analysis of PROTECT
Background: Antibiotic resistance is a public health threat driven in part by indiscriminate antibiotic administration, which can exert changes in the resistome. Days of antibiotic...
Abstract 4361179: Dynamic Associations of Metabolic Obesity Phenotype Transitions with Cardiovascular Disease in Middle-Aged and Elderly Adults: Insights from a Multinational Longitudinal Study
Background: Obesity is a major risk factor for cardiovascular disease (CVD), but individuals can differ in their metabolic health status, leading to varying CVD risks. Metabolic he...
Abstract 4368316: A Novel Variant in <i>MYBPC</i> 3 Causes Hypertrophic Cardiomyopathy by Haploinsufficiency
Background: Familial hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease (CVD ) . Related mutations contribu...
Abstract 4360460: Rapidly Progressive Cardiogenic Shock in a 19-Year-Old Woman
Background: Cardiogenic shock is caused by a wide range of pathogenic processes that negatively impact myocardial function and is associated with very elevated mortality rates....
Abstract 4363659: Implementing a Mediterranean Diet App in Patients with Atrial Fibrillation: A Pilot Study
Background: Atrial fibrillation (AF) is a common arrhythmia associated with inflammation, symptom burden, and impaired quality of life (QoL). The Mediterranean diet may reduce infl...
Abstract 4371119: Atypical Approach to Typical AVNRT Ablation in Patients with Persistent Left Superior Vena Cava: A Single-Centre Experience
Background: Persistent left superior vena cava (PLSVC) is a rare congenital venous anomaly that can complicate the anatomy of the right atrium and coronary sinus, posing technical...
Abstract 4366149: A REPORT OF >2000 CONSECUTIVE NON-SELECTED PATIENTS UNDERGOING IMAGING WITH PACEMAKER'S AND ICD'S IN THE MRI ENVIRONMENT; THE ADDITIVE VALUE OF A LARGE, PROSPECTIVE >20-YEAR OBSERVATIONAL STUDY
Background: While imaging of conventional PM’s and ICDs is infrequently performed via MRI, many studies, including the MagnaSafe have unequi...
Abstract 4361525: Influence of Cardiovascular Magnetic Resonance Imaging Phenotype and Variant Type on Ventricular Arrhythmia Risk in RBM20-Related Cardiomyopathy
Background: Pathogenic/likely pathogenic (P/LP) variants in the RBM20-encoded RNA-binding protein motif 20 splicing factor result in a penetrant form of arrhythmogenic/dilated card...
Abstract 4364649: SGLT2 Inhibitors Reduce Mortality and Improve Cardiac Biomarkers in Cardiac Amyloidosis: A Systematic Review and Meta-Analysis
Background: Cardiac amyloidosis (CA), comprising transthyretin (ATTR) and light-chain (AL) subtypes, is an important yet underidentified mimic of heart failure with preserved eject...
Abstract 4344647: Loss of Rgs5 Promotes Pericyte Differentiation into Contractile Cells and Vascular Remodeling
Background: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by progressive vascular remodeling, leading to increased pulmonary arterial pressure and right ve...
Abstract 4340723: Comparative Study of Coronary Artery Disease (CAD) Prediction: Conventional QRISK3 vs. Enhanced Machine Learning Models Combined with Particle Swarm Optimization (PSO) Algorithm
Background: Coronary Artery Disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CA...